Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease

心肺健康和疾病领域心血管生物工程研究和技术开发培训

• 批准号: 10614653
• 负责人: Karen L Christman
• 金额: $ 32.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614653
• 关键词: Biomedical Engineering; Cardiopulmonary; Cardiovascular system; Disease; Health; Training; research and development; technology development

Project Summary This proposal for pre-doctoral training on “Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease”, aims to train outstanding and diverse predoctoral bioengineering students in applying quantitative and integrative interdisciplinary approaches to basic and translational research in cardiopulmonary, vascular, blood and sleep pathophysiology and in developing novel technologies for the diagnosis, treatment and clinical management of cardiovascular and cardiopulmonary diseases. The curriculum is built on four intersecting technology themes that the Bioengineering training faculty are expert in: (a) Biomechanics and Mechanobiology; (b) Biomaterials, Cell and Tissue Engineering; (c) Computational and Systems Biology; and (d) Imaging and Biophotonics. Trainees will take coursework with a concentration in two of these themes. Training faculty from the biomedical sciences will serve as required interdisciplinary co-mentors in the major scientific areas including basic and translational cardiopulmonary, vascular and blood research. The goal is to develop a new generation of bioengineers who become innovators in research and technology development for improving cardiovascular health. The leadership team has three MPIs: Dr. Andrew McCulloch (contact PI), chairs the Steering Committee (SC) and is responsible for administration, admissions and evaluation. Dr. Karen Christman will be primarily responsible for translational research training and Dr. Geert Schmid-Schönbein will oversee program-specific activities including curriculum, seminars, and the annual retreat and symposium. The training faculty includes outstanding and well-funded bioengineers, basic biomedical scientists, physician-scientists and public health experts with exceptionally strong records of collaborative research training. The SC has established effective recruitment, admission, training and evaluation procedures that ensure a large and diverse pool of well-qualified candidates, 100% retention, and excellent outcomes. The curriculum will include required program-specific courses in Cardiovascular Physiology, Molecular Biology of the Cardiovascular System, Patient-Centered Clinical Medicine for Bioengineers, Data Science for Cardiovascular Bioengineering, Responsible Conduct of Research and Rigor and Reproducibility, as well as bioengineering electives from two or more of the four technology themes. With our record of successful junior faculty career development, we include seven outstanding and diverse new junior engineering faculty recruited since 2017, including one who has a joint clinical appointment in Cardiovascular Medicine. They will co-mentor trainees in new areas including biophotonics, medical imaging, precision biomaterials, pulmonary arterial hypertension, heart valve disease, and neurovascular injury. All faculty will receive mentorship training, and program progress and outcomes will be assessed by two advisory committees and trainee surveys. The outcome will be scientists who use integrative, technology-driven approaches to advance cardiovascular science and healthcare.

项目概要 关于“生物工程研究与技术开发”博士前培训的建议 “心血管与心肺健康与疾病”，旨在培养优秀、多元化的博士前人才 生物工程专业的学生应用定量和综合跨学科方法进行基础研究 心肺、血管、血液和睡眠病理生理学以及转化研究 开发心血管疾病诊断、治疗和临床管理的新技术 该课程建立在四个交叉的技术主题之上。 生物工程培训教师是以下领域的专家：(a) 生物力学和机械生物学；(b) 生物材料、细胞和 组织工程；(c) 计算和系统生物学；(d) 成像和生物光子学。 培训生物医学科学的教师将集中学习其中两个主题的课程。 作为主要科学领域（包括基础和转化）所需的跨学科联合导师 目标是培养新一代的心肺、血管和血液研究生物工程师。 成为改善心血管健康的研究和技术开发的创新者。 领导团队由 3 位 MPI 组成：Andrew McCulloch 博士（联系人 PI），指导委员会 (SC) 主席和 负责管理、招生和评估。Karen Christman 博士将主要负责。 用于转化研究培训，Geert Schmid-Schönbein 博士将监督特定项目的活动 包括课程、研讨会、年度务虚会和研讨会。 杰出且资金雄厚的生物工程师、基础生物医学科学家、医师科学家和公共卫生 SC 建立了有效的合作研究培训记录。 招聘、录取、培训和评估程序，确保拥有大量多样化的人才 合格的候选人、100% 的保留率和优秀的成果。 心血管生理学、心血管系统分子生物学、 以患者为中心的生物工程师临床医学、心血管生物工程数据科学、 负责任的研究行为和严谨性和可重复性，以及两个生物工程选修课 凭借我们成功的初级教师职业发展记录，我们可以确定四个技术主题中的一个或多个。 包括自 2017 年以来招募的优秀且多样化的新初级工程教师，其中包括一名 他们将在心血管医学领域进行联合临床任命，共同指导新领域的学员。 包括生物光子学、医学影像、精密生物材料、肺动脉高压、心脏瓣膜 所有教师都将接受指导培训以及项目进展和 结果将由两个咨询委员会和实习生调查进行评估，结果将由科学家进行。 他们使用综合的、技术驱动的方法来推进心血管科学和医疗保健。