Clinical Laboratory & Biomarker Core

临床实验室

基本信息

批准号：
10612986
负责人：
Craig Walter Hendrix
金额：
$ 48.76万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-02 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612986
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Area Awareness Biological Biological Assay Biological Markers Biological Specimen Banks Biological Testing Cataloging Certification Clinic Clinical Clinical Data Clinical Research Collaborations Consult Consultations Data Data Analyses Development Educational process of instructing Equipment and supply inventories Faculty Goals Guidelines HIV HIV Infections Immunology Institution International Internet Investigation Knowledge Laboratories Maintenance Measures Mentors Methods Natural History Outcome Study Pathogenesis Performance Pharmacology Practice Management Prevention Publications Quality Control Readiness Research Research Personnel Resources Sampling Science Scientist Service provision Services Specimen Students Testing Tissue Banks Training biobank data integrity data management design improved innovation metabolomics next generation programs quality assurance repository searchable database service providers virology working group

项目摘要

The overall goals of the JHUCFAR Laboratory core are to provide JHU HIV researchers, especially those new to HIV, with: a) world‐class laboratory expertise to assist in the optimal design of clinical studies where specialized laboratory assays are essential to measuring study outcomes, b) access to appropriate, validated and, where applicable, certified laboratory assays, c) biomarker specimen repository for the storage, cataloguing and testing of biological specimens, including access to the clinical data associated with those specimens, and d) training to match the needs of investigators ranging from understanding how to collaborate with laboratory investigators, incorporate laboratory tests in a clinical study, judge assay quality and readiness for use to actual performance of the assays in one’s own laboratory. The Core will establish mechanisms to enhance research in HIV prevention, treatment, and pathogenesis carried out by both new and established investigators at JHU through improved awareness of and access to the extensive laboratory resources within the institution and by establishing connections outside Johns Hopkins when needed. To this end, the Core will directly provide expert consultation and assay service focused in 4 major scientific areas—virology, immunology, pharmacology, and metabolomics—as well as providing access to both data and biological specimen repositories to advance science. Beyond these laboratories, the Core will establish best data management practices – from clinic to lab to data analysis – and facilitate connections and collaborations with a far broader array of core laboratories within JHU and in other CFARs nationally.

JHUCFAR 实验室核心的总体目标是为 JHU HIV 研究人员，特别是那些 HIV 新手，具有：a) 世界一流的实验室专业知识，可协助临床研究的最佳设计当专门的实验室检测对于衡量研究结果至关重要时，b) 获得适当的、经过验证的和（如适用）经认证的实验室测定，c) 生物标志物样本用于存储、编目和测试生物样本的存储库，包括访问与这些标本相关的临床数据，以及 d) 满足研究人员需求的培训从了解如何与实验室研究人员合作、整合实验室临床研究中的测试，判断测定质量和用于实际测定性能的准备情况核心将建立加强艾滋病毒预防研究的机制，约翰霍普金斯大学的新老研究人员通过以下方式进行了治疗和发病机制的研究：提高对机构内广泛实验室资源的认识和获取，并通过需要时在约翰霍普金斯大学外部建立联系，核心将直接提供。专家咨询和检测服务专注于4个主要科学领域——病毒学、免疫学、药理学和代谢组学，以及提供数据和生物样本的访问除了这些实验室之外，核心还将建立最好的数据。管理实践——从诊所到实验室再到数据分析——并促进联系和与 JHU 和全国其他 CFAR 中更广泛的核心实验室进行合作。