Drug Discovery for Parasitic Diseases

寄生虫病药物发现

基本信息

批准号：
9045149
负责人：
DAVID L. WOODLAND
金额：
$ 0.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-01-06 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9045149
关键词：
Academia Advanced Development African Trypanosomiasis Antiparasitic Agents Biology California Cells Cessation of life Chagas Disease Chemicals Cities Clinical Trials Collaborations Communication Drug Combinations Drug Kinetics Drug Targeting Drug resistance Drug toxicity Emerging Technologies Fostering Fruit Genomics Goals Helminths Human Industry Infection Knowledge Lead Leishmaniasis Malaria Methodology Methods Nature Organism Outcome Parasites Parasitic Diseases Parasitic infection Parasitology Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacotherapy Phase Play Process Protozoa Regimen Research Research Personnel Role Safety Schistosomiasis Science Scientist Staging Technology Therapy Evaluation Validation Work base biological systems candidate selection cheminformatics chemoproteomics clinical practice drug development drug discovery drug metabolism high throughput screening human disease improved interest meetings metabolomics novel novel therapeutics pathogen posters programs public health relevance resistance mechanism screening small molecule libraries student training symposium transcriptomics

项目摘要

DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Drug Discovery for Parasitic Diseases, organized by Leann M. Tilley, Philip J. Rosenthal and Kelly Chibale. The meeting will be held in Tahoe City, California from January 24-28, 2016. Parasitic organisms, including protozoa and helminths, are among the most significant human pathogens, causing billions of infections and millions of deaths each year. For many parasitic diseases, available therapies are unsatisfactory and increasingly threatened by drug resistance. New therapies, ideally directed against novel targets, are urgently needed. Recent advances in anti-parasitic drug discovery have come from three different approaches - target-based methods that build on improved understanding of parasite biology; phenotypic high throughput screens, that are benefitting from improved technology; and repositioning and repurposing drugs developed for other indications. These different approaches all benefit from the integration of medicinal chemistry with parasitology and pharmacotherapy programs. This conference will showcase cutting-edge anti-parasitic drug discovery programs that illustrate the path from parasite biology to lead identification and from optimization to candidate selection. It will emphasize the need for coordinated integration of programs in medicinal chemistry, parasite biology, pharmacokinetics, and safety assessment. It will feature emerging technologies such as chemical biology, chemoproteomics, chemical informatics, genomics, transcriptomics and metabolomics that are facilitating drug discovery. It will also discuss the current status of anti-parasitic drug resistance and advances in our understanding of mechanisms of resistance. The conference should be of interest to medicinal chemists, parasitologists, experts in drug discovery and development, pharmacologists and clinicians targeting the protozoa and helminths that cause serious human disease, including malaria, African and American trypanosomiasis, leishmaniasis, schistosomiasis and multiple other parasitic infections.

描述（由申请人提供）：请求支持由 Leann M. Tilley、Philip J. Rosenthal 和 Kelly Chibale 组织的题为“寄生虫病药物发现”的 Keystone 研讨会。该会议将于 1 月在加利福尼亚州塔霍市举行。 2016 年 24-28 日。寄生生物，包括原生动物和蠕虫，是最重要的人类病原体之一，分别造成数十亿例感染和数百万人死亡对于许多寄生虫病来说，现有的治疗方法并不令人满意，并且日益受到耐药性的威胁，迫切需要针对新靶点的新疗法，抗寄生虫药物发现的最新进展来自三种不同的方法——基于靶点的方法。建立在对寄生虫生物学的深入了解的基础上；受益于改进技术的表型高通量筛选；以及针对其他适应症开发的药物的重新定位和重新利用这些不同的方法都受益于药物化学与药物化学的结合。本次会议将展示前沿的抗寄生虫药物发现计划，阐述从寄生虫生物学到先导化合物鉴定以及从优化到候选药物选择的路径。它将强调药物化学、寄生虫领域协调整合的必要性。它将以化学生物学、化学蛋白质组学、化学信息学、基因组学、转录组学和代谢组学等促进药物发现的新兴技术为特色。药物化学家、寄生虫学家、药物发现和开发专家、药理学家以及针对导致严重人类疾病（包括疟疾）的原生动物和蠕虫的群体应该对抗寄生虫药物耐药性以及我们对耐药机制的理解进展感兴趣。、非洲和美洲锥虫病、利什曼病、血吸虫病和多种其他寄生虫感染。