Hyperpolarized MRI Technology Resource Center

超极化 MRI 技术资源中心

• 批准号: 10611457
• 负责人: Daniel B Vigneron
• 金额: $ 17.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611457
• 关键词: Acceleration; Address; Advisory Committees; Clinical; Clinical Research; Communities; Computer software; Decision Making; Development; Educational workshop; Environment; Event; Extramural Activities; Feedback; Funding; Geography; Goals; Industry; Infrastructure; Institution; International; Leadership; Magnetic Resonance Imaging; Minnesota; National Institute of Biomedical Imaging and Bioengineering; Newsletter; Procedures; Productivity; Publications; Reporting; Research; Research Personnel; Resources; Services; Site; Source; Structure; Techniques; Technology; Training; Training Activity; Training Support; Translations; Universities; clinical translation; design; experience; human subject; improved; instrumentation; member; new technology; organizational structure; pre-clinical research; programs; radiologist; skills; symposium; synergism; technology development; tool; web site

Administration Project Summary/Abstract The Hyperpolarized MRI Technology Resource Center (HMTRC) is designed to be timely, nimble and highly productive in the development of new hyperpolarized (HP) MR instrumentation, techniques, acquisition and analysis software through push-pull interactions with Collaborative Project (CP) investigators. In parallel, another key goal of the center is to disseminate these newly developed technologies to the Service Project (SP) Investigators for extramural feedback and to the general scientific community through the new website, symposia/seminar, monthly newsletter, annual HP MR Technology Workshops, and hands-on training. In order to accomplish all these goals and functions, a carefully-constructed administrative plan has been developed & refined over the past 10 years, with a clearly defined, but dynamic structure that can be modified to meet new challenges and changing collaborative, service, training and dissemination needs. This has required a detailed organizational structure to enable “team decision-making”, so that each member of the team can provide their specialized input for optimal technology development and translation to address unmet scientific and/or clinical needs. The HMTRC administrative structure and implementation have evolved considerably since the original submission as the interactions and complexity of the P41 have increased dramatically over the past ten years. These improvements have also benefited from great institutional support, input from many experienced sources including the external advisory committee (EAC), leading experts in HP technology, the HP Radiologist Leadership & Translational Advisory committees, NIBIB Program Staff, and interactions with other P41 centers. The HMTRC administrative infrastructure now extends nationally to provide information, dissemination of novel technologies to CPs, SPs, and other investigators conducting HP 13C MRI preclinical and clinical research. As stated in their attached report: “The EAC … is unanimous in their assessment that the HMTRC is high functioning as an NCBIB. The HMTRC has led the nation (and the world) in the development and translation of HP MRI through a unique combination of skills, expertise, instrumentation, environment, clinical engagement, and industry engagement, which simply does not exist elsewhere. The HMTRC will continue to serve as a critical national resource through the next funding cycle as the field of HP MRI expands and matures, particularly with the clinical translation of new HP agents, and more sites engaging in research involving human subjects. The restructured Center benefits from clear and enhanced synergy between all TR&Ds and Collaborative Projects that are more broadly geographically distributed”.

行政项目总结/摘要 超极化 MRI 技术资源中心 (HMTRC) 旨在及时、灵活且高度 在开发新型超极化 (HP) MR 仪器、技术、采集和 同时，另一个项目是通过与协作项目（CP）研究人员的推拉交互来分析软件。 该中心的主要目标是将这些新开发的技术传播给服务项目（SP） 研究人员通过新网站向外部和一般科学界提供反馈， 专题讨论会/研讨会、每月通讯、年度 HP MR 技术研讨会以及实践培训。 为了实现所有这些目标和职能，制定了精心构建的行政计划 经过过去 10 年的改进，具有明确定义但动态的结构，可以进行修改以满足新的要求 挑战和不断变化的协作、服务、培训和传播需求。 建立“团队决策”的组织架构，让团队的每个成员都能提供自己的想法 用于最佳技术开发和转化的专门投入，以解决未满足的科学和/或临床问题 需要。 自最初成立以来，HMTRC 的管理结构和实施已经发生了很大变化。 由于 P41 的交互性和复杂性在过去十年中急剧增加，因此提交。 这些改进还得益于强大的机构支持以及许多经验丰富的来源的投入 包括外部咨询委员会 (EAC)、惠普技术领先专家、惠普放射科医生 领导力和转化咨询委员会、NIBIB 项目人员以及与其他 P41 中心的互动。 HMTRC 的行政基础设施现已扩展到全国范围内，以提供信息、传播新颖的信息 向 CP、SP 和其他进行 HP 13C MRI 临床前和临床研究的研究人员提供技术。 在其所附报告中指出：“EAC……一致认为 HMTRC 运作良好 作为 NCBIB，HMTRC 在 HP MRI 的开发和翻译方面处于全国（乃至世界）领先地位。 通过技能、专业知识、仪器、环境、临床参与和的独特组合 HMTRC 将继续发挥关键作用。 随着 HP MRI 领域的扩展和成熟，特别是在下一个资助周期中，国家资源 新 HP 药物的临床转化，以及更多从事人类受试者研究的网站。 重组后的中心受益于所有 TR&D 和合作项目之间明确和增强的协同作用 地理分布更广泛。”