George M. O'Brien Kidney Research Core Centers

乔治·M·奥布莱恩肾脏研究核心中心

基本信息

批准号：
9104144
负责人：
MARY H. FOSTER
金额：
$ 116.23万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9104144
关键词：
Academic Medical Centers Address Animal Model Area Atherosclerosis Basic Science Biological Biometry Blood Pressure Cardiovascular Diseases Cardiovascular system Cause of Death Chronic Kidney Failure Clinical Clinical Research Clinical Sciences Consultations DNA Databases Discipline Disease model Doctor of Philosophy Education End stage renal failure Feasibility Studies Fostering Foundations Funding Genetic Genetic Screening Genetic study Genomics Heart failure Human Genetics Hypertension Informatics Institutes Institutional Review Boards Instruction International Kidney Kidney Diseases Link Metabolic Diseases Metabolic syndrome Modeling Mus Patients Phenotype Physiological Pilot Projects Preparation Renal Replacement Therapy Renal function Research Research Design Research Institute Research Personnel Research Support Resources Sampling Sequence Analysis Services Singapore Staging Support Groups Techniques Tissue Banking Tissue Banks Translational Research Transplantation Ursidae Family Zebrafish base blood pressure regulation cardiovascular risk factor data management design exome sequencing genome wide association study human subject interest investigator training mortality next generation sequencing power analysis programs repository translational medicine whole genome

项目摘要

PROJECT SUMMARY (See instructions): Composite Cardiovascular disease is the major cause of death for patients with kidney disease. The causes of this preponderance of cardiovascular disease in patients with kidney disease are not clear. Hypertension is also highly prevalent in patients with chronic kidney disease (CKD), representing the second most common cause of end-stage renal disease in the US. Elevated blood pressure amplifies cardiovascular risk and promotes progression of CKD irrespective of the primary cause. Since a patient with CKD is more likely to die from cardiovascular disease than to require renal replacement therapy, exaggerated cardiovascular risk is arguably the most pressing clinical problem facing nephrologists and their patients. Accordingly, the major objective of the George M. OBrien Kidney Research Core Center at Duke is to promote and support research into understanding the unique links between the kidney, cardiovascular disease, and hypertension. We recognize that progress in this area will require multi-disciplinary teams of investigators with broad expertise across a range of disciplines in the clinical and basic sciences. To this end, our Center will mobilize unique resources at Duke University Medical Center to bear upon this daunting clinical problem including. Taking advantage of our robust international research base, we will accomplish our objective through the following specific aims: (1) Develop education programs designed to highlight the importance of the interrelationship of kidney and cardiovascular disease, to inform Center investigators of the latest advances in relevant research, and to train investigators in clinical and basic science approaches to advance research. (2) Support pilot and feasibility studies to explore new areas of research relevant to the kidney in cardiovascular diseases serving as a foundation for other external funding. (3) Establish an Animal Models Core to support basic discovery research. (4) Establish a Renal Genetics Core to provide intellectual and technical support for understanding the genetics of kidney and cardiovascular diseases including hypertension. (5) Establish a Clinical/Translational Core to foster and facilitate clinical and translational research on the inter-relationships among CKD, hypertension, and cardiovascular disease.

项目摘要（参见说明）：复合材料心血管疾病是肾病患者死亡的主要原因。肾病患者罹患心血管疾病的比例如此高，其原因尚不清楚。高血压在慢性肾病 (CKD) 患者中也很常见，是美国终末期肾病的第二大常见原因。无论主要原因如何，血压升高都会增加心血管风险并促进 CKD 的进展。由于 CKD 患者死于心血管疾病的可能性比需要肾脏替代治疗的可能性更大，因此夸大的心血管风险可以说是肾科医生及其患者面临的最紧迫的临床问题。因此，杜克大学乔治·M·奥布莱恩肾脏研究核心中心的主要目标是促进和支持研究，以了解肾脏、心血管疾病和高血压之间的独特联系。我们认识到，这一领域的进展需要由具有临床和基础科学各学科广泛专业知识的多学科研究团队组成。为此，我们中心将动员独特的力量杜克大学医学中心的资源来解决这个令人畏惧的临床问题，包括。利用我们强大的国际研究基础，我们将通过以下具体目标来实现我们的目标： (1) 制定教育计划，旨在强调肾脏和心血管疾病相互关系的重要性，向中心研究人员通报相关领域的最新进展。研究，并培训研究人员临床和基础科学方法以推进研究。（2）支持试点和可行性研究，探索与心血管疾病中的肾脏相关的新研究领域，为其他外部资金奠定基础。 (3) 建立支持基础发现研究的动物模型核心。（4）建立肾脏遗传学核心，为了解高血压等肾脏和心血管疾病的遗传学提供智力和技术支持。 (5) 建立临床/转化核心，以促进和促进 CKD、高血压和心血管疾病之间相互关系的临床和转化研究。