Strategic and Plasticity Interventions for Late Life Depression in Community Settings

社区环境中晚年抑郁症的战略和可塑性干预措施

• 批准号: 8996065
• 负责人: Patricia A. Arean
• 金额: $ 17.33万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8996065
• 关键词: Address; Affect; Anterior; Antidepressive Agents; Applications Grants; Award; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain region; Clinical; Clinical Trials; Cognitive; Color; Complex; Conflict (Psychology); Depressed mood; Development; Disease; Dorsal; Educational Curriculum; Elderly; Faculty; Fertilization; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Home environment; Impaired cognition; Intervention; Intervention Studies; Knowledge; Learning; Low income; Measures; Mental Depression; Mental Health; Mentors; Mentorship; Methods; Mood Disorders; Moods; National Institute of Mental Health; Nature; Neurobiology; Neuropsychology; Observational Study; Outcome; Paper; Participant; Patients; Pattern; Performance; Persons; Postdoctoral Fellow; Prefrontal Cortex; Process; Psychotherapy; Recommendation; Recruitment Activity; Research; Research Personnel; Role; Sampling; Scanning; Science; Scientist; System; Thinking; Time; Training; Visit; Work; World Health Organization Disability Assessment Schedule; base; behavioral neurology; career; cingulate cortex; cognitive neuroscience; community setting; disability; environmental change; ethnic diversity; executive function; experience; geriatric depression; improved; interest; mild cognitive impairment; next generation; novel strategies; problem solving therapy; programs; psychologic; response; skills; theories; treatment response

DESCRIPTION (provided by applicant): This is a competing renewal of a mid-career mentor award that was originally titled "Treating Depression in Low-Income Elderly with CIND/aMCI" and is now titled Strategic and Plasticity Interventions for Late Life Depression in Community Settings. The title change reflects the additional training I wish to pursue in the next five years of my career. In the original award, I studied neuropsychology and behavioral neurology associated with mild cognitive impairment. This experience allowed me to develop interventions that would address cognitive moderators of psychotherapy outcomes, and to mentor the next generation of psychotherapy researchers who are also interested in the intersection of cognitive impairments and the treatment of mood disorders in late life. That award resulted in 20 papers and 5 grant applications (4 were subsequently funded), the development of a mentoring program for junior faculty in my home department and personal mentorship of 9 junior faculty at UCSF, 3 faculty outside the UC system and 7 post doctoral fellows. In this proposal, I wish to study cognitive neuroscience of late life depression (LLD) and to learn more about plasticity interventions and their potential role in the treatment of LLD. My intent is not to change who I am as a researcher, but learn enough about these two vast fields so that I can (1) integrate what I learn from biological theory with the knowledge I already possess about psychological and sociological explanations of LLD, (2) work collaboratively with cognitive neuroscientists and plasticity interventionists to develop targeted behavioral interventions for LLD, and (3) add my expertise in the development of portable and geriatric friendly behavioral interventions to the field of plasticity intervention research. I believe this training will allow for better and mutual cross fertilization between the fields of psychotherapy and cognitive neuroscience, which will serve to improve mental health research directions. Because few scientists in our field have attempted to engage in this type of cross fertilization, I plan to also develop a training curriculum for post-doctoral fellows focused on the intersection of behavioral interventions research and cognitive neuroscience, to develop a generation of psychotherapy researchers who can work collaboratively with biologically oriented researchers in the treatment of late life mood disorders.

描述（由申请人提供）：这是对中期导师奖的竞争更新，该奖项最初名为“用CIND/AMCI在低收入老年人中治疗抑郁症”，现在标题为社区环境中晚期生活抑郁症的战略和可塑性干预措施。标题更改反映了我在职业生涯的未来五年中希望接受的额外培训。在最初的奖项中，我研究了与轻度认知障碍相关的神经心理学和行为神经病学。这种经验使我能够制定干预措施，以解决心理治疗结果的认知主持人，并指导下一代的心理治疗研究人员，他们对认知障碍的交汇以及晚期情绪障碍的治疗也很感兴趣。该奖项导致了20篇论文和5份赠款申请（后来获得了4份赠款），这是我在我的家庭部门的初级教职员工制定的指导计划，并在UCSF的9名初级教职员工制定了个人指导，UC系统以外的3位教职员工和7个博士后。在此提案中，我希望研究晚期抑郁症（LLD）的认知神经科学，并了解有关可塑性干预措施及其在LLD治疗中的潜在作用的更多信息。我的意图是不要改变我作为研究人员的身份，而是对这两个广阔领域的知识足够多，以便我可以（1）将我从生物学理论中学到的知识与我已经对LLD的心理和社会学解释所拥有的知识相结合，（2）（2）与认知神经科学家和可塑性疗法的共同工作，以开发有针对性的行为，以开发有针对性的行为，并在lld and and cription and cription and cription and Indriia and cormiation and growisial intriiation（3））（3）的范围（3））塑料干预研究领域的干预措施。我相信，这种培训将使心理治疗和认知神经科学领域之间进行更好和相互的交叉施肥，这将有助于改善心理健康研究方向。由于我们领域中很少有科学家试图从事这种交叉施肥，因此我计划还开发了一项培训课程，用于专注于行为干预研究与认知神经科学相交的博士后研究员，以开发一代心理治疗研究人员，他们可以与以生物学为方位的研究人员进行治疗，以治疗以后的生活情绪差异。

项目成果

The Use and Effectiveness of Mobile Apps for Depression: Results From a Fully Remote Clinical Trial.

• DOI: 10.2196/jmir.6482
• 发表时间: 2016-12-20
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Arean PA;Hallgren KA;Jordan JT;Gazzaley A;Atkins DC;Heagerty PJ;Anguera JA
• 通讯作者: Anguera JA

Does Cognition Predict Treatment Response and Remission in Psychotherapy for Late-Life Depression?

• DOI: 10.1016/j.jagp.2014.09.003
• 发表时间: 2015-02-01
• 期刊: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 7.2
• 作者: Beaudreau, Sherry A.;Rideaux, Tiffany;Arean, Patricia
• 通讯作者: Arean, Patricia

Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial.

• DOI: 10.1002/da.22588
• 发表时间: 2017-06
• 期刊: Depression and anxiety
• 影响因子: 7.4
• 作者: Anguera JA;Gunning FM;Areán PA
• 通讯作者: Areán PA

Corrigendum to 'Does Cognition Predict Treatment Response and Remission in Psychotherapy for Late-Life Depression?' [The American Journal of Geriatric Psychiatry 23 (2015) 215-219].

“认知能否预测晚年抑郁症心理治疗的治疗反应和缓解？”的勘误表

• DOI: 10.1016/j.jagp.2018.12.020
• 发表时间: 2019
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Beaudreau,SherryA;Rideaux,Tiffany;O'Hara,Ruth;Arean,Patricia
• 通讯作者: Arean,Patricia