Neural and affective mechanisms underlying prospective self-control costs

潜在自我控制成本的神经和情感机制

基本信息

批准号：
10660515
负责人：
Candace M Raio
金额：
$ 43.67万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-04 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10660515
关键词：
Address Affect Affective Anterior Behavior Behavior Control Behavioral Biological Assay Brain Brain region Buffers Choice Behavior Clinical Cognitive Computer Models Corpus striatum structure Cost Control Cost Measures Data Decision Making Diagnostic Dissociation Dorsal Down-Regulation Economics Equipment and supply inventories Exercise Exposure to Failure Food Future Goals Healthy Eating Human Impairment Individual Intervention Laboratories Literature Maps Measures Mediation Mediator Mental disorders Methodology Modeling Motivation Neurocognitive Neurosecretory Systems Outcome Participant Patient Self-Report Pattern Physiological Play Population Prefrontal Cortex Process Psychological Stress Psychopathology Reporting Resources Rewards Risk Factors Role Self Perception Self-control as a personality trait Shapes Stimulus Stress Stress Tests Testing Time Work access restrictions behavioral response biological adaptation to stress cingulate cortex cognitive task cost cost estimate improved neural neural circuit neural correlate neuroimaging neuromechanism neurophysiology novel preference promote resilience prospective psychosocial response smoking cessation social stem stressor theories tool

Address Affect Affective Anterior Behavior Behavior Control Behavioral Biological Assay Brain Brain region Buffers Choice Behavior Clinical Cognitive Computer Models Corpus striatum structure Cost Control Cost Measures Data Decision Making Diagnostic Dissociation Dorsal Down-Regulation Economics Equipment and supply inventories Exercise Exposure to Failure Food Future Goals Healthy Eating Human Impairment Individual Intervention Laboratories Literature Maps Measures Mediation Mediator Mental disorders Methodology Modeling Motivation Neurocognitive Neurosecretory Systems Outcome Participant Patient Self-Report Pattern Physiological Play Population Prefrontal Cortex Process Psychological Stress Psychopathology Reporting Resources Rewards Risk Factors Role Self Perception Self-control as a personality trait Shapes Stimulus Stress Stress Tests Testing Time Work access restrictions behavioral response biological adaptation to stress cingulate cortex cognitive task cost cost estimate improved neural neural circuit neural correlate neuroimaging neuromechanism neurophysiology novel preference promote resilience prospective psychosocial response smoking cessation social stem stressor theories tool

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项目摘要

Project Summary Self-control failures are a universal challenge for healthy and clinical populations. Recent theoretical and empirical work suggests these failures may arise from excessive cognitive costs associated with exercising control. However, traditional self-control paradigms do not provide a methodological platform to quantify these costs. Further, we know little about the neural basis of self-control costs nor how these representations change under different classes of psychological stress, which is a major risk factor for self-control failure. To address this, we developed a novel decision-making task that measures how much individuals will pay to restrict access to tempting rewards that may derail their long-term goals and lead to self-control failure (precommitment). Here, we aim to use an expanded and refined version of this newly validated tool to examine neurocomputational and affective mechanisms underlying prospective self-control costs and how they relate to real-world self-control failures. In Aim 1, we seek to identify the computational, motivational and cognitive mechanism that gives rise to self-control costs. We will model the cost function for self-control, test how this metric relates to cognitive constructs typically implicated in self-control in the literature and disentangle the motivational mechanism underlying the use of precommitment. In Aim 2 we seek to characterize the neural correlates of self-control costs, track how activity within these regions dynamically fluctuate depending on the feature of food stimuli participants focus on and identify neural mediators and connectivity patterns stemming from these costs. In Aim 3, we seek to examine how different classes of stressor type (physiological, social, or lifetime stress) shapes the behavioral and neural representations of self-control costs. Characterizing individuals’ self-control cost function and how these costs are represented in the brain will allow for a more direct test of how stress exposure affects decisions to use self-control and may lead to potential interventions that can buffer individuals from the effects of stress on such decisions.

项目摘要自我控制失败是健康和临床人群的普遍挑战。最近的理论和经验工作表明，这些失败可能是由于与运动相关的认知成本过剩而引起的控制。但是，传统的自我控制范式没有提供量化这些方法的方法论平台费用。此外，我们对自我控制成本的神经基础一无所知，也不了解这些代表如何改变在不同类别的心理压力下，这是自我控制失败的主要危险因素。解决这，我们制定了一项新颖的决策任务，该任务衡量了个人将支付多少以限制访问权限诱人的奖励，可能会破坏其长期目标并导致自我控制失败（预定）。这里，我们的目的是使用该新验证工具的扩展和精致版本来检查神经计算和潜在的自我控制成本及其与现实世界自我控制的关系的情感机制失败。在AIM 1中，我们试图确定产生的计算，动机和认知机制自我控制成本。我们将对自我控制的成本函数进行建模，测试该指标与认知如何相关在文献中通常在自我控制中实现的构造，并解开动机机制潜在的使用预订。在AIM 2中，我们试图表征自我控制成本的神经相关性，跟踪这些区域内的活动如何根据食物刺激参与者的特征动态波动关注并确定由这些成本引起的神经介体和连通性模式。在AIM 3中，我们寻求检查不同类别的压力类型（生理，社会或终生压力）如何塑造行为和自我控制成本的神经表示。表征个人的自我控制成本功能以及如何这些成本在大脑中代表，将允许对压力暴露如何影响决策进行更直接的测试使用自我控制并可能导致潜在的干预措施，从而使个人摆脱压力的影响这样的决定。