Mentoring Obesity and Diabetes Research in Louisiana

指导路易斯安那州的肥胖和糖尿病研究

• 批准号: 9320355
• 负责人: Thomas W Gettys
• 金额: $ 20.98万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9320355
• 关键词: Adipose tissue; Affect; Basic Science; Biochemical; Bioinformatics; Biomedical Research; Cells; Cellular biology; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Clinical Research; Core Facility; Country; Development; Diabetes Mellitus; Disease; Elements; Ensure; Environment; Event; Extramural Activities; Faculty; Fostering; Funding; Genomics; Goals; Grant; Growth; Growth and Development function; Health; High Prevalence; Homeostasis; Incidence; Institution; Interdisciplinary Study; Knowledge; Louisiana; Mentors; Metabolic Diseases; Metabolic syndrome; Mission; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Pathology; Phase; Pilot Projects; Population; Population Sciences; Positioning Attribute; Prevention strategy; Preventive Medicine; Process; Productivity; Public Health; Quality of life; Recording of previous events; Regulation; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Thinness; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; base; bioimaging; carbohydrate metabolism; education research; effective therapy; energy balance; improved; insight; lipid metabolism; member; novel therapeutics; nutrition; organizational structure; outreach; programs; public health relevance; success; treatment strategy

 DESCRIPTION (provided by applicant): Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center was established to enhance research on metabolic disease by increasing the number of extramurally-funded faculty devoted to this research and expanding the scientific infrastructure needed for its conduct. During Phases I and II of our COBRE, our Center has provided support to 15 junior faculty members who have obtained 14 NIH grants (7 RO1, 2 RO3, 1 R21, 1 R56, 2 R41, 1 R43) and 5 research grants from the ADA. In addition, the research infrastructure has been significantly improved by (1) enhancement of the Genomics Core through hardware upgrades and addition of Bioinformatics support to the core's activities, and (2) establishment of an outstanding, well equipped Cell Biology and Bio-imaging Core that has provided high levels of expertise and service to institutional faculty and Project PIs supported by our COBRE. The Specific Aims of our COBRE in Phase III are to further expand the critical mass of productive investigators engaged in metabolic disease research by (a) maintaining the highly effective mentoring culture we have built and refined during the first two phases of our Center; (b) identifying, mentoring, and retaining our most talented, well-trained junior scientists emerging from our institutional training grants; (c) continuing to enhance the growth of our scientific cores by leveraging institutional support to sustain their strong positive impact on the success of Center scientists, and (4) sustaining a collaborative multidisciplinary research environment by providing support for research pilot projects that are critical to obtaining new extramural support and sustaining the Center's basic and translational research activities.

 描述（由应用提供）：近三分之二的美国人口在临床上超重或肥胖，几乎10％的人口患有成人发作的糖尿病。肥胖和糖尿病是一组统称为“代谢综合征”的病理簇的中心元素。我们在Pennington生物医学研究中心建立了卓越生物医学研究中心（COBRE），以增加专门用于这项研究的外部资助的教师的数量来增强对代谢疾病的研究，并扩大其行为所需的科学基础设施。在我们的鞋底I和II阶段，我们的中心为15名初级教师提供了支持，他们获得了14名NIH赠款（7 RO1、2 RO3、1 R21、1 R21、1 R56、2 R41、1 R43）和5项来自ADA的研究补助金。此外，通过（1）通过硬件升级增强基因组学核心并增加了对核心活动的生物信息学支持，以及（2）建立一个出色的，设备齐全的细胞生物学和生物成像核心，从而为机构的专业知识和服务提供了高水平的专业知识和服务。我们在第三阶段的毛病的具体目的是通过（a）维持我们在中心的前两个阶段中建立和完善的高效心理文化，进一步扩大从事代谢疾病研究的关键批量； （b）识别，心理和保留我们从机构培训赠款中脱颖而出的最有才华，训练有素的初级科学家； （c）通过利用机构支持来维持对中心科学家成功的强烈积极影响，以继续增强我们的科学核心的增长，（4）通过为获得新的基本支持和维持中心的基本研究和翻译研究活动至关重要的研究飞行员项目来维持协作的多学科研究环境。