Administrative Core

行政核心

• 批准号: 9978090
• 负责人: Thomas W Gettys
• 金额: $ 23.47万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9978090
• 关键词: Address; Adipocytes; Advisory Committees; Biogenesis; Biomedical Research; Cell physiology; Cellular biology; Centers of Research Excellence; Clinical; Collaborations; Communication; Complement; Core Facility; Development; Diabetes Mellitus; Education and Outreach; Elements; Endocrine; Environment; Epigenetic Process; Extramural Activities; Faculty; Family Study; Fostering; Funding; Funding Mechanisms; Future; Genetic Markers; Genomics; Glucose; Goals; Grant; Hepatic; Homeostasis; Human; Individual; Inflammation; Inflammatory; Infrastructure; Institutes; Institution; International; Investments; Laboratories; Link; Louisiana; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Mitochondria; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Pathology; Phase; Pilot Projects; Population; Principal Investigator; Process; Productivity; Proteins; Quebec; Records; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Sampling; Scientist; Secure; Senior Scientist; Skeletal Muscle; Structure of beta Cell of islet; Talents; Training; Training Activity; Transgenic Organisms; Translational Research; Work; base; bioimaging; experience; fatty acid metabolism; fibroblast growth factor 21; flexibility; innovation; lipid biosynthesis; multidisciplinary; neuromechanism; next generation; novel; novel strategies; operation; programs; recruit; senior faculty; success; translational approach

Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center is leading an effort to enhance research on metabolic disease by mentoring our most promising young scientists to independence by senior scientists within the Center. The scope of work undertaken by COBRE scientists encompasses a combination of cellular, molecular, and translational approaches to address questions ranging from neural mechanisms of glucose sensing and energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic programming in obesity, regulation of mitochondrial biogenesis in adipocytes, and the role of inflammation in pancreatic beta cell function. Our COBRE has developed the scientific infrastructure to support the pursuit of these diverse objectives by establishing state of the art Genomics, Cell Biology and Bioimaging, and Transgenic Cores. The Specific Aims of our COBRE in Phase III are to further expand the critical mass of productive investigators engaged in obesity/diabetes research by (a) develop and retain outstanding new junior faculty from within the institution and mentor them to sustainable independent funding (b) recruit outstanding junior and senior faculty engaged in metabolic disease research that complement existing strengths of Center investigators; (c) develop and foster new opportunities for collaborative interactions with institutional colleagues by instituting a new Pilot and Feasibility funding program, (d) enhance utilization of the outstanding research infrastructure developed within the Cell Biology and Bioimaging, Genomics, and Transgenic core facilities in Phase III through development of training modules and outreach activites. The critical metrics of success are to expand the number of extramural grants obtained by the COBRE faculty, increase the number of faculty engaged in metabolic diseases research, leverage COBRE support to expand the quality of our scientific cores through increased utilization and investment of institutional resources.

美国近三分之二的美国人口在临床上超重或肥胖，几乎是10％ 人口患有成人糖尿病。肥胖和糖尿病是簇的中心元素 统称为“代谢综合征”的病理。我们的生物医学中心 Pennington生物医学研究中心的卓越研究卓越（COBRE）正在领导 通过指导我们最有前途的年轻人来增强代谢疾病的研究 科学家由中心内的高级科学家独立。进行的工作范围 由鞋底科学家包含了细胞，分子和翻译的组合 解决葡萄糖传感的神经机制和问题的方法 能量稳态，与脂肪生成有关的炎症机制，表观遗传学 肥胖中的编程，脂肪细胞中线粒体生物发生的调节以及 胰腺β细胞功能的炎症。我们的毛病已经开发了科学 通过建立艺术状态来支持这些多样化目标的基础设施 基因组学，细胞生物学和生物成像以及转基因核心。我们的具体目的 第三阶段的毛线将进一步扩大参与的生产研究人员的关键质量 （a）在肥胖/糖尿病研究中开发和保留从内部发展和保留出色的新初级教师 该机构并指导他们为可持续的独立资金（b）招募杰出的初级 和高级教师从事代谢疾病研究，以补充现有的优势 中心调查员； （c）开发并促进与与之合作互动的新机会 机构同事通过制定新的飞行员和可行性资金计划，（d）增强 利用细胞生物学内开发的杰出研究基础设施和 第三阶段的生物成像，基因组学和转基因核心设施通过发展 培训模块和外展活动。成功的关键指标是扩大 山cor教师获得的壁外赠款数量，增加教师的数量 从事代谢性疾病研究，利用鞋底支持来扩大我们的质量 科学核心通过增加的机构资源的利用和投资。