Genomic Instability and DNA Repair

基因组不稳定性和 DNA 修复

• 批准号: 10608878
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-28 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608878
• 关键词: Acceleration; Affect; Antineoplastic Agents; Area; Attention; Biology; COVID-19 pandemic; Canada; Cell division; Cell physiology; Chromatin; Clinic; Collaborations; Communication; DNA Repair; DNA biosynthesis; Development; Disease; Educational workshop; Fertilization; Genome Stability; Genome engineering; Genomic DNA; Genomic Instability; Immune signaling; Inflammatory; International; Knowledge; Learning; Malignant Neoplasms; Medical; Methodology; Molecular; Nuclear; Outcome; Physiological; Poly(ADP-ribose) Polymerase Inhibitor; Process; Public Health; Reaction; Research; Research Personnel; Science; Scientist; Signal Transduction; Students; Underrepresented Minority; Vacuum; Virus Diseases; Woman; Work; acute stress; cancer immunotherapy; clinical practice; disorder control; human disease; improved; next generation; novel therapeutic intervention; pandemic disease; posters; programs; single molecule; small molecule inhibitor; symposium; targeted agent; treatment strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled Genomic Instability and DNA Repair, organized by Drs. Katharina Schlacher, Irene Chiolo and Ralph Scully. The conference will be held in Whistler, BC, Canada from March 19-23, 2023. DNA replication and repair are critical processes that initiate, orchestrate, and affect a broad range of fundamental physiological reactions, ultimately promoting cell division, genome stability, and proper cellular physiology. The field of genome stability is rich in mechanistic understanding that directly led to development of small molecule inhibitors such as PARP inhibitors, now used standardly in the clinic as anti-cancer agents. Nuclear genome stability actors, however, do not act in a vacuum, but interact, communicate and collaborate with diverse intrinsic and extrinsic cellular processes. The field is at the cusp of the next level of understanding of how diverse cellular and physiological reactions directly work together with genome stability mechanisms on a molecular level and how to use this understanding to develop new treatment strategies against human diseases. The control and governance of inflammatory and immune signaling reactions as it relates to replication and chromatin reactions in particular is a potentially potent cutting-edge connection for the field, given the importance of these reactions during immunotherapy of cancer. This is enabled specifically by the continued development of single molecule targeting agents, which have arise from the strong molecular understanding of the field. The knowledge of how to control and direct inflammatory signaling will propel our understanding of how to control diseases beyond cancer. This includes viral infections, which are of particular relevance to public health during the recent pandemic. This Keystone Symposia conference will highlight the latest advances and emerging concepts in the field, aspiring to prompt rich discussions especially focused on implications for medical biology, disease and treatment strategies. This conference focusing on DNA replication and repair will be held jointly with a conference on Precision Genome Engineering, providing outstanding opportunities for cross-fertilization between these two complementary fields.

抽象的 请求支持题为“基因组不稳定性和 DNA 修复”的 Keystone Symposia 会议， 由博士组织。卡塔琳娜·施拉彻、艾琳·奇奥洛和拉尔夫·斯卡利。会议将在惠斯勒举行 加拿大不列颠哥伦比亚省，2023 年 3 月 19 日至 23 日。 DNA 复制和修复是启动、协调和影响广泛范围的关键过程。 基本的生理反应，最终促进细胞分裂、基因组稳定性和适当的细胞 生理。基因组稳定性领域有着丰富的机制理解，直接导致了发展 小分子抑制剂，如 PARP 抑制剂，目前在临床上标准用作抗癌药物 代理。然而，核基因组稳定性参与者并不是在真空中行动，而是相互作用、沟通和 与不同的内在和外在细胞过程协作。该领域正处于下一个水平的风口浪尖 了解不同的细胞和生理反应如何与基因组稳定性直接协同作用 分子水平上的机制以及如何利用这种理解来开发新的治疗策略 对抗人类疾病。炎症和免疫信号反应的控制和治理 与复制和染色质反应有关，特别是对于 鉴于这些反应在癌症免疫治疗过程中的重要性。这是专门通过 单分子靶向药物的不断发展，这些药物源于强大的分子 对这个领域的了解。了解如何控制和引导炎症信号传导将推动我们 了解如何控制癌症以外的疾病。这包括病毒感染，特别是 与最近大流行期间的公共卫生相关。本次 Keystone 研讨会将重点介绍 该领域的最新进展和新兴概念，渴望引发丰富的讨论，特别关注 对医学生物学、疾病和治疗策略的影响。本次会议聚焦DNA 复制和修复将与精密基因组工程会议联合举行，提供 这两个互补领域之间的交叉施肥的绝佳机会。