Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis

经常同时使用酒精和大麻对神经行为的影响

• 批准号: 10608419
• 负责人: EMILY B ANSELL
• 金额: $ 73.01万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608419
• 关键词: Address; Alcohol consumption; Alcohols; Behavior; Behavioral; Behavioral Mechanisms; Biological; Blood; Brain; Cannabis; Consumption; Control Groups; Corpus striatum structure; Cues; Data; Drug usage; Ecological momentary assessment; Exhibits; Female; Functional Magnetic Resonance Imaging; Future; Heavy Drinking; Hydrocortisone; Individual; Individual Differences; Intervention; Knowledge; Life; Marijuana; Measurement; Measures; Neurosecretory Systems; Outcome; Participant; Pathway interactions; Pattern; Persons; Plasma; Prevention; Process; Reporting; Risk; Risk Factors; Role; Sampling; Sex Differences; Stress; Substance Use Disorder; Time; Work; alcohol craving; alcohol response; binge drinker; blood oxygen level dependent; cannabis craving; comparison control; craving; cue reactivity; experience; follow-up; male; marijuana legalization; marijuana use; marijuana user; neural; neurobehavioral; neuroimaging; prevent; prospective; recruit; response; secondary analysis; sex; substance use; substance user; time interval

Project Summary Simultaneous use of alcohol and marijuana/cannabis (SAM) leads to increased craving, use, and consequences compared to single use of either alcohol or cannabis. However, there is a dearth of knowledge regarding the neural, neuroendocrine, and behavioral differences in SAM users that increases risk for these negative outcomes. The current proposal aims to address this significant gap in knowledge by examining how stress related neural and neuroendocrine processes may differ in SAM users relative to single substance users or a control group. A sex-balanced sample of four hundred forty male and female individuals reporting SAM use, alcohol use only, cannabis use only, or neither binge/heavy alcohol use nor cannabis use will be recruited to complete a neuroimaging session and three 14-day bursts of ecological momentary assessment (EMA) over the course of one year. During the neuroimaging session, participants will complete a stress cue reactivity task while undergoing fMRI and will also have blood drawn to assess stress-induced cortisol response. Participants will complete a baseline EMA burst that focuses on daily experiences of stress, craving and drug use, and will complete follow-up bursts at 6- and 12-months post-baseline. This proposal aims to better understand how stress processes are related to increased risk among SAM users. Specifically this proposal will investigate 1) how neural and neuroendocrine responses to stress are moderated by group (i.e., SAM, alcohol-only, cannabis-only, control), sex, and the interaction of group x sex; 2) how group, sex, and group x sex interactions, and neural/ neuroendocrine responses moderate the momentary relationships between stress and craving/use in daily life; and 3) how group, sex, and group x sex interactions, and neural/neuroendocrine responses moderate the trajectory of craving/use over a one-year follow-up period. Broadly, we expect that while single substance users will have some dysregulation, SAM users will exhibit the greatest stress dysregulation relative to controls, and females (vs. males) will demonstrate greater dysregulation of neural/neuroendocrine responses to stress, greater momentary relationships between stress and craving/use, and steeper trajectories of craving/use. Successful completion of these aims will significantly advance our understanding of the mechanisms by which SAM use increase risk for substance use disorders and other negative outcomes, which will be key in guiding future intervention and prevention efforts.

项目概要 同时使用酒精和大麻 (SAM) 会导致渴望、使用和大麻的增加 与单独使用酒精或大麻相比的后果。但知识还是有欠缺 关于 SAM 用户的神经、神经内分泌和行为差异，这些差异增加了这些风险 负面结果。当前的提案旨在通过研究如何解决这一重大知识差距 SAM 使用者与单一物质使用者相比，与压力相关的神经和神经内分泌过程可能有所不同 或对照组。由四百四十名报告 SAM 的男性和女性个体组成的性别平衡样本 使用、仅使用酒精、仅使用大麻、或既不酗酒也不使用大麻的情况将被招募 完成一次神经影像学检查和三次为期 14 天的生态瞬时评估 (EMA) 一年的历程。在神经影像学会议期间，参与者将完成压力提示反应任务 同时进行功能磁共振成像，还将抽血来评估压力引起的皮质醇反应。参加者 将完成基线 EMA 爆发，重点关注压力、渴望和药物使用的日常体验，并将 在基线后 6 个月和 12 个月进行完整的随访。该提案旨在更好地了解如何 压力过程与 SAM 用户的风险增加有关。具体来说，本提案将调查 1) 神经和神经内分泌对压力的反应如何通过群体来调节（即 SAM、仅饮酒、 仅大麻，对照）、性别以及 x 组性别的相互作用； 2) 群体、性别和群体 x 性别如何 相互作用和神经/神经内分泌反应调节压力和压力之间的瞬时关系 日常生活中的渴望/使用； 3) 群体、性别和群体 x 性别如何相互作用，以及神经/神经内分泌 在一年的随访期内，反应缓解了渴望/使用的轨迹。总的来说，我们期望 虽然单一物质使用者会出现一些调节失调，但 SAM 使用者会表现出最大的压力 相对于对照组，女性（相对于男性）会表现出更大的失调 神经/神经内分泌对压力的反应，压力和渴望/使用之间更大的瞬时关系， 以及更陡峭的渴望/使用轨迹。成功完成这些目标将极大地推进我们的 了解 SAM 使用增加物质使用障碍和其他疾病风险的机制 负面结果，这将是指导未来干预和预防工作的关键。