MAPP Research Network Tissue Analysis and Technology Core

MAPP 研究网络组织分析和技术核心

• 批准号: 9120855
• 负责人: M. Scott Lucia
• 金额: $ 49.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-09 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120855
• 关键词: Adopted; Aliquot; Archives; Area; Biochemical; Biological; Biological Assay; Biological Markers; Bladder; Blood; Body Fluids; Chronic Fatigue Syndrome; Clinic; Clinical; Code; Collection; Colorado; Communication; Consent; Creatinine; DNA; Data; Data Coordinating Center; Diagnosis; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Etiology; Fibromyalgia; Fractionation; Genomics; Genotype; Goals; Health Insurance Portability and Accountability Act; Housing; Individual; Institutional Review Boards; Irritable Bowel Syndrome; Malignant Neoplasms; Measurement; Measures; Medical; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pain Research; Pathway interactions; Patients; Pattern; Pelvic Pain; Pelvis; Phase; Phenotype; Platelet Factor 4; Practice Guidelines; Procedures; Process; Proteins; Proteomics; Quality Control; Research Personnel; Residual state; Resources; Role; Sampling; Sensory; Services; Site; Specimen; Specimen Handling; Statistical Models; Symptoms; Syndrome; Technology; Testing; Time; Tissues; United States National Institutes of Health; Universities; Urine; Work; biobank; biological research; chronic pelvic pain; clinical practice; cohort; instrument; interdisciplinary approach; medical specialties; meetings; neuroimaging; operation; pain symptom; potential biomarker; public health relevance; repository; response; sample collection; screening; success; symptomatic improvement; urinary; urologic

DESCRIPTION (provided by applicant): This is an application from the Tissue Analysis and Technology Core (TATC), currently housed at the University of Colorado Anschutz Medical Campus (UCAMC), to continue participation in the MAPP Research Network (RN) in response to RFA-DK-13-507 circulated on 8/23/2013. The primary responsibilities of the TATC will be to support the trans-MAPP longitudinal Symptom Patterns Study (SPS) by providing expertise and services in the areas of 1) biospecimens collection, processing, management and distribution for trans-MAPP proteomic, infectious etiology, and genomic studies, 2) centralized ELISA and analyte testing including protein and creatinine quantifications and quality control testing on MAPP biospecimens, and 3) centralized genotyping of the trans-MAPP cohort. The TATC will serve as the repository for all body fluid specimens collected during the MAPP SPS; process these specimens using customized, quality controlled, and documented best practice procedures; and to provide these biospecimens to MAPP investigators to meet the objectives of the MAPP RN. The TATC will collaborate closely with the MAPP Data Coordinating Center (DCC) and Executive Committee to ensure that the goals of the MAPP RN are successfully met. The TATC will meet all NIH quality standards and will provide specimens to researchers according to IRB, HIPAA and NIDDK procedures that protect the confidentiality of all consented patients whose tissue and blood are archived. In accordance with the terms set forth in the RFP, the TATC will prepare all residual samples from the MAPP RN for transfer to the NIDDK Central Biorepository. The TATC will work with the NIDDK Central Biorepository to coordinate procedures for collection, coding, storage and eventual transfer as directed by the NIDDK.

描述（由申请人提供）：这是组织分析和技术核心（TATC）的申请，目前位于科罗拉多大学Anschutz Medical Campus（UCAMC），以继续参与MAPP研究网络（RN），以响应RFA-DK-13-507在8/23/2013散发。 TATC的主要责任将是通过在1）的领域提供专业知识和服务来支持反式MAPP纵向症状模式研究（SPS）。1）生物测量收集，处理，管理和分布，用于跨性型蛋白质组织，感染性病因和基因组研究，包括基因组和分析量和分析量的蛋白质定量和质量，包括原始量和分析量的固定剂和质量，反式MAPP队列的集中基因分型。 TATC将作为MAPP SPS期间收集的所有体液标本的存储库；使用自定义，质量控制和记录的最佳实践程序处理这些标本；并向MAPP调查人员提供这些生物测量，以实现MAPP RN的目标。 TATC将与MAPP数据协调中心（DCC）和执行委员会紧密合作，以确保成功实现MAPP RN的目标。 TATC将符合所有NIH质量标准，并根据IRB，HIPAA和NIDDK程序为研究人员提供标本，以保护所有组织和血液都存档的同意患者的机密性。根据RFP中规定的术语，TATC将准备所有来自MAPP RN的残留样品，以转移到NIDDK Central Biorepository。 TATC将与NIDDK Central Biorepository合作，协调按NIDDK指示的收集，编码，存储和最终转移的程序。