Biophysical muscle modeling software for enhancing open science

用于增强开放科学的生物物理肌肉建模软件

• 批准号: 10607769
• 负责人: Timothy C Cope
• 金额: $ 21.31万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-16 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607769
• 关键词: Address; Adopted; Affect; Aging; Animals; Behavioral; Biological; Biological Process; Biomedical Computing; Biophysical Process; Biophysics; Cardiac; Cerebral Palsy; Clinical; Code; Collaborations; Communities; Computer software; Disease; Educational workshop; Elements; Energy Metabolism; Equilibrium; Formulation; Foundations; Funding; Generations; Goals; Health; Heart Diseases; Heart Research; Human; In Vitro; Joints; Length; Letters; Libraries; Link; Mechanics; Modeling; Movement; Muscle; Muscle Fibers; Muscle Proteins; Muscle function; Musculoskeletal; Musculoskeletal Diseases; Output; Performance; Pharmacological Treatment; Postdoctoral Fellow; Process; Publishing; Pythons; Research; Research Personnel; Sensorimotor functions; Skeletal Muscle; Standardization; Techniques; Testing; United States National Institutes of Health; base; biomechanical model; biophysical model; biophysical techniques; cloud based; computational platform; experience; experimental study; improved; innovation; insight; interest; interoperability; multi-scale modeling; nervous system disorder; novel; open data; open source; parent grant; phenomenological models; repository; response; scientific computing; simulation; spasticity; virtual

Project Summary The goal of this supplement is to enable a large community of musculoskeletal modeling researchers to easily access and robustly use validated biophysical muscle models generated by the parent grant to generate multiscale simulations of muscle function. To date, there are extremely few musculoskeletal movement simulations (<5) that use biophysically-based muscle models; those that are available are not easily generalizable for use by other researchers. Research from the parent grant establishes new, experimentally- validated formulations of biophysical muscle models to reproduce novel features of muscle force generation for understanding sensorimotor function in behavioral and clinical contexts. We use the MyoSim software platform developed by Co-I Campbell to demonstrate the superiority of biophysical muscle models over standard phenomenological models used in musculoskeletal simulations of movement. However, it will be difficult for other researchers to easily implement these models in other movement contexts. This supplement will enable broader dissemination of our ongoing and prior research, to enhance open science and accelerate progress in multiscale modeling in the muscle, cardiac, and musculoskeletal modeling communities. Software Supplement Aim 1 will improve, standardize, and document MyoSim software so that it can be easily integrated with other multiscale simulations on scientific computing platforms such as MATLAB and Python. Software Supplement Aim 2 will integrate MyoSim muscle models with OpenSim, an NIH-funded musculoskeletal simulation platform with ~70,000 users. The supplement will also support virtual tutorial workshops aimed at muscle modeling researchers including muscle and cardiac researchers, including those using finite element models, and the OpenSim musculoskeletal modeling community. Creating open, generalizable and extensible MyoSim functionality for multiscale modeling will increase scientific innovation and enhance open science in musculoskeletal research, and dramatically increase the MyoSim user base.

项目概要 该补充的目标是使肌肉骨骼建模研究人员的大型社区能够轻松地 访问并稳健地使用由家长资助生成的经过验证的生物物理肌肉模型来生成 肌肉功能的多尺度模拟。迄今为止，肌肉骨骼运动极少 使用基于生物物理的肌肉模型进行模拟（<5）；那些可用的并不容易 可供其他研究人员推广使用。来自家长资助的研究建立了新的、实验性的- 验证了生物物理肌肉模型的配方，以重现肌肉力量产生的新特征 了解行为和临床环境中的感觉运动功能。我们使用MyoSim软件平台 由 Co-I Campbell 开发，用于展示生物物理肌肉模型相对于标准的优越性 用于肌肉骨骼运动模拟的现象学模型。然而，这将很难 其他研究人员可以在其他运动环境中轻松实现这些模型。该补充将使 更广泛地传播我们正在进行的和先前的研究，以加强开放科学并加速进展 肌肉、心脏和肌肉骨骼建模领域的多尺度建模。软件 补充目标 1 将改进、标准化和记录 MyoSim 软件，以便轻松使用 与科学计算平台（例如 MATLAB 和 Python）上的其他多尺度模拟集成。 软件补充 Aim 2 将 MyoSim 肌肉模型与 NIH 资助的 OpenSim 集成 拥有约 70,000 位用户的肌肉骨骼模拟平台。该补充品还将支持虚拟教程 针对肌肉建模研究人员（包括肌肉和心脏研究人员）的研讨会 使用有限元模型和 OpenSim 肌肉骨骼建模社区。创造开放、 用于多尺度建模的可推广和可扩展的 MyoSim 功能将促进科学创新 加强肌肉骨骼研究的开放科学，并大幅增加 MyoSim 用户群。