BIOSTATISTICS/BIOINFORMATICS

生物统计学/生物信息学

基本信息

批准号：
7414791
负责人：
PETER D. EMANUEL
金额：
$ 83.05万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7414791
关键词：
Advisory Committees Animals Bioinformatics Biometry Brain Breast Cancer Center Clinical Research Clinical Trials Clinical trial protocol document Communication Computer software Consultations Data Data Analyses Data Collection Databases Development Education Ensure Gene Expression Guidelines Image Informatics Interdisciplinary Study Malignant Neoplasms Mass Spectrum Analysis Methodology Online Systems Ovarian Pancreas Participant Pathology Pathway Analysis Patients Policies Procedures Proteomics Protocols documentation Randomized Reproduction spores Research Design Research Methodology Research Personnel Research Proposals Research Support Resources Retrieval Sample Size Students System Systems Analysis Techniques Testing Tissue Banks Tissue Procurements Training United States National Institutes of Health anticancer research data management design mathematical model oncology

项目摘要

DESCRIPTION (provided by applicant): The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to serve as a focal point from which the Center's investigators may draw statistical and bioinformatic expertise for planning, management and analysis of their studies. The specific aims of the Biostatistics Shared Facility are to: 1) coordinate and manage statistical and bioinformatic activities in the Cancer Center to ensure that investigators have ready access to statistical and bioinformatic consultation and support; 2) provide statistical expertise in study design, including research proposal development; 3) provide data analysis for Cancer Center projects using contemporary statistical and bioinformatic methodologies; 4) maintain the clinical trial protocol and patient registration data management system for the Cancer Center Clinical Studies Unit and further develop protocol specific databases for the Center's clinical trials; 5) develop and manage a comprehensive database for each of the Center's four SPOREs to serve as a multidisciplinary research resource for SPORE investigators; 6) develop and manage web-based data management systems for the Center's Gene Expression and Mass Spectroscopy/Proteomic Shared Facilities; 7) develop and manage image storage, retrieval and analysis system for the Center's Small Animal Image Shared Facility; 8) be an active participant and collaborator of the NCI's Cancer Bioinformatics Grid (caBIG) Initiatives; 9) maintain a computing facility with up-to-date software for data management, data analysis, and network communications; and provide support for the Cancer Center's Data Sharing Plan; 10) perform methodology research in biostatistics and bioinformatics that will enhance the BBSF's technical capabilities and requirements in providing collaborative research support; and 11) provide training opportunities and education in biostatistics and bioinformatics to graduate students, oncology residents, fellows and Cancer Center investigators. The BBSF will be operated under the specific usage policies and priority guidelines established with the advise of its Advisory Committee.

描述（由申请人提供）：生物统计学和生物信息学共享设施（BBSF）的主要目标是作为一个焦点，中心的研究人员可以从中汲取统计和生物信息学专业知识，以规划、管理和分析他们的研究。生物统计共享设施的具体目标是： 1）协调和管理癌症中心的统计和生物信息活动，以确保研究人员能够随时获得统计和生物信息咨询和支持； 2) 提供研究设计方面的统计专业知识，包括研究提案的制定； 3) 使用当代统计和生物信息方法为癌症中心项目提供数据分析； 4) 维护癌症中心临床研究部的临床试验方案和患者注册数据管理系统，并进一步开发中心临床试验的方案特定数据库； 5）开发和管理该中心四个 SPORE 的综合数据库可作为 SPORE 研究人员的多学科研究资源； 6) 为中心的基因表达和质谱/蛋白质组学共享设施开发和管理基于网络的数据管理系统； 7) 开发和管理中心小动物图像共享设施的图像存储、检索和分析系统； 8) 成为 NCI 癌症生物信息学网格 (caBIG) 计划的积极参与者和合作者； 9) 维护具有最新软件的计算设施，用于数据管理、数据分析和网络通信；并为癌症中心的数据共享计划提供支持； 10）开展生物统计学和生物信息学方面的方法论研究，以提高BBSF提供协作研究支持的技术能力和要求； 11) 为研究生、肿瘤住院医师、研究员和癌症中心研究人员提供生物统计学和生物信息学方面的培训机会和教育。 BBSF 将根据特定规定运作根据咨询委员会的建议制定使用政策和优先准则。