Bringing South African Men into HIV Counseling and Testing (HCT) and Care

让南非男性接受艾滋病毒咨询和检测 (HCT) 和护理

• 批准号: 9107520
• 负责人: Thomas J. Coates
• 金额: $ 52.65万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-07 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107520
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Africa South of the Sahara; African; Area; Attention; Bedside Testings; Behavioral; CD4 Positive T Lymphocytes; Caring; Case Management; Child; Communities; Cost Effectiveness Analysis; Counseling; Diagnosis; Economics; Ensure; Family; Female; Gender; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; Health; High Prevalence; Home environment; Household; Human immunodeficiency virus test; Individual; Infection; Intervention; Joints; Life Expectancy; Link; Maintenance; Morbidity - disease rate; National Institute of Mental Health; Outcome; Personal Satisfaction; Population; Prevention; Process; Quality of life; Randomized; Research; Resources; South Africa; South African; Testing; Time; Uganda; Viral; Viral Load result; Woman; Women' s Health; Work; antiretroviral therapy; base; community intervention; cost; cost effectiveness; design; disability-adjusted life years; evidence base; falls; improved; innovation; intervention effect; male; men; mortality; point of care; standard of care; transmission process

 DESCRIPTION (provided by applicant): The ultimate objective of this research is to provide evidence-based strategies to improve treatment of HIV+ men. Treatment as prevention (TasP) can only work through a three step process: (1) Testing a significant proportion of the population, (2) linkage to care and (3) maintaining in care a significant proportion of HIV+ individuals to the point of viral suppression. The benefits of increased testing, linkage to and maintenance in care for men would be enormous. We propose a study that combines structural and individual level interventions and integrates the results to address our overall objective of maintenance in care to the point of viral suppression. Aim 1: In a cluster-randomized study, we will investigate whether male-centered mobilization and testing increases the population-level percentage of men who have been tested (within the last 12 months) by more than 10 absolute percentage points. Aim 2: In the individually-randomized design, we will investigate whether POC CD4 testing and individualized case management improves linkage to care (immediately following diagnosis) and viral suppression (12 months later) over POC CD4 testing alone and standard of care. Aim 3: Integrate the results of the two trial components (Aims 1 and 2) to evaluate the joint effect of the interventions on the percentage of HIV+ men who are effectively tested, linked to care and maintained with undetectable VL. The benefits of increased testing, linkage to and maintenance in care for men would be enormous. Men would remain healthier longer, could work and support their families, contribute to rather than deplete household economic resources, raise their children, and they would be less likely to transmit HIV to female partners

 描述（由适用提供）：这项研究的最终目标是提供基于证据的策略来改善对艾滋病毒+男性的治疗。作为预防（TASP）的治疗只能通过三个步骤进行工作：（1）测试很大比例的人群，（2）与护理的联系，（3）维持很大比例的HIV+个体，以达到病毒抑制的地步。增加测试，与男性护理的维护和维护的好处将是巨大的。我们提出了一项研究，将结构和个体水平干预结合在一起，并整合结果，以解决我们在护理中的总体维护目标，直到病毒抑制。 AIM 1：在一项集群过程中，我们将调查以男性为中心的动员和测试是否会增加经过测试（在过去12个月内）的男性人口级别的百分比，超过10个绝对百分比。 AIM 2：在单独随机设计中，我们将研究POC CD4测试和个性化病例管理是否可以改善与POC CD4测试和护理标准的CD4测试（12个月后）和病毒抑制（12个月后）的联系。 AIM 3：整合两个试验组件的结果（目标1和2），以评估干预措施对有效测试的HIV+男性百分比的关节作用，这些男性经过有效测试，与CARE相关并保持了无法检测到的VL。增加测试，与男性护理的维护和维护的好处将是巨大的。男人将保持更长的健康状况，可以工作和支持家人，贡献而不是复制家庭经济资源，抚养子女，而他们不太可能将艾滋病毒传递给女性伴侣