Biostatistics and Informatics Facility Core

生物统计和信息学设施核心

• 批准号: 10600129
• 负责人: Juw Won Park
• 金额: $ 18.36万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600129
• 关键词: Address; Animals; Area; Basic Science; Bayesian Method; Big Data; Bioinformatics; Biomedical Research; Biometry; Cancer Center; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Communities; Computational Biology; Consultations; Core Facility; Data; Data Analyses; Dedications; Deposition; Diagnosis; Disease; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Funding; Gender; Genetic; Goals; Grant; Health; Human; Human Resources; Informatics; Infrastructure; Kentucky; Life; Life Style; Measurement; Measures; Mediator; Methods; Modeling; Multiomic Data; National Institute of Environmental Health Sciences; Network Infrastructure; Phase; Play; Pollution; Population Research; Population Study; Prevention; Productivity; Public Health; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Science; Services; Strategic Planning; Superfund; Techniques; Toxic Environmental Substances; Training; Universities; alcohol research; bioinformatics tool; cofactor; community based participatory research; community engagement; cost efficient; data infrastructure; design; disorder risk; epidemiology study; health science research; interest; lifestyle factors; member; patient oriented; pollutant; population health; pre-clinical; spatiotemporal; statistics; tool

The long-term objective of the Center for Integrated Environmental Health Sciences (CIEHS) is to build a framework that integrates studies on the interactions between combined exposure to pollutants and life style factors), in order to understand their role in human health and disease risk at various life stages and as modified by gender. The Biostatistics and Informatics Facility Core (BIFC) plays a vital role in supporting CIEHS research by providing state-of-the-art statistical and bioinformatics support and training to all CIEHS members. The BIFC is an essential resource for designing systematic acquisition and deposition of preclinical and clinical data as well as for providing intellectual input required for rigorous data analysis. Building the framework to integrate translational basic science research on pollution and lifestyle cofactors influencing chronic disease risk requires sophisticated statistical support. The BIFC addresses this need by using state-of- art techniques related to statistics and informatics as it serves CIEHS members during all phases of their studies. The BIFC provides seamless infrastructure and support to CIEHS member research, including preclinical-basic science, patient-oriented clinical research (e.g., the diagnosis, prevention, and therapy of environmentally-related disorders), public health/population-based research, and community-engaged / community-led research. The aims of the BIFC are: 1. Provide state-of-the-art statistical support in design, analysis and dissemination of findings of a range of basic science, translational, clinical, population health and environmental epidemiology studies; 2. Provide support for the integration of multi-omics data from both animal and human studies; 3. Facilitate integration of exposure data with lifestyle factors to identify effect modifiers and mediators of the health effects of environmental exposures; 4. Educate center investigators, staff and trainees in new methods related to statistics/omics approaches applicable to their research activities. Areas of special interest include, repeated measures models, measurement error, spatio-temporal methods, computational biology, statistical genetics, clinical informatics and Bayesian methods. Several CIEHS members currently use the statistical support services of the BIFC Director and staff, demonstrating both need and productive interactions. An IDeA grant to the Kentucky Biomedical Research Infrastructure Network and INBRE provides partial support for some BIFC bioinformatics personnel and access to a variety of bioinformatics and statistical tools. By leveraging and building upon existing resources at UofL, the BIFC is able to facilitate access and use of these resources by CIEHS members and expand statistical and bioinformatics support in a more cost efficient manner.

综合环境健康科学中心（CIEHS）的长期目标是建立一个 整合污染物联合暴露与生活方式之间相互作用研究的框架 因素），以了解它们在不同生命阶段的人类健康和疾病风险中的作用，并作为 按性别修改。生物统计和信息学设施核心（BIFC）在支持方面发挥着至关重要的作用 通过向所有 CIEHS 提供最先进的统计和生物信息学支持和培训来开展 CIEHS 研究 成员。 BIFC 是设计系统性采集和沉积临床前药物的重要资源 和临床数据以及提供严格数据分析所需的智力输入。建设 整合污染和影响生活方式辅助因素的转化基础科学研究的框架 慢性病风险需要复杂的统计支持。 BIFC 通过使用现状来满足这一需求 与统计和信息学相关的艺术技术，为 CIEHS 成员在其各个阶段提供服务 研究。 BIFC 为 CIEHS 成员研究提供无缝基础设施和支持，包括 临床前基础科学、以患者为中心的临床研究（例如，疾病的诊断、预防和治疗） 环境相关疾病）、公共卫生/基于人群的研究以及社区参与/ 社区主导的研究。 BIFC 的目标是： 1. 提供最先进的设计统计支持， 分析和传播一系列基础科学、转化、临床、人口健康和 环境流行病学研究； 2.为两种动物的多组学数据整合提供支持 和人类研究； 3. 促进暴露数据与生活方式因素的整合，以确定影响调节因素 以及环境暴露对健康影响的中介因素； 4. 对中心研究人员、工作人员和 与适用于其研究活动的统计/组学方法相关的新方法的受训者。领域 特别感兴趣的包括，重复测量模型，测量误差，时空方法， 计算生物学、统计遗传学、临床信息学和贝叶斯方法。多个CIEHS 成员目前使用 BIFC 主任和工作人员的统计支持服务，这表明他们需要 和富有成效的互动。 IDeA 向肯塔基州生物医学研究基础设施网络提供资助 INBRE 为一些 BIFC 生物信息学人员提供部分支持，并获得各种信息 生物信息学和统计工具。通过利用和建立伦敦大学的现有资源，BIFC 能够促进 CIEHS 成员获取和使用这些资源，并扩大统计和 以更具成本效益的方式提供生物信息学支持。