Integrative Health Sciences Core

综合健康科学核心

• 批准号: 9052187
• 负责人: GARY W MILLER
• 金额: $ 31.24万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9052187
• 关键词: Basic Science; Biology; Clinical Research; Community Outreach; Development; Educational workshop; Environmental Exposure; Environmental Health; Epidemiologic Studies; Faculty; Figs - dietary; Health; Health Sciences; Human; Integrative Medicine; International; Lead; Leadership; Link; Mission; National Institute of Environmental Health Sciences; Patients; Pilot Projects; Population; Positioning Attribute; Research; Research Project Grants; Resources; Science; Services; Societies; Staging; Surveillance Methods; Systems Biology; Technology; Time; Translational Research; Translations; Work; base; bench to bedside; career development; complex biological systems; design; health application; improved; novel; nutrition; programs; symposium; tool; training opportunity

The mission of the IHFSC Is to facilitate translation and integration of basic science research on environmental exposures into population and personalized health applications, with an emphasis on the impact of exposures on complex biological systems that change dynamically over time. This mission is driven by the overall theme of HERCULES to use exposome-based concepts and approaches to improve human health. A key aspect of the ISHFC is to operationalize exposome-related research and is primarily designed to provide access to, tools and research approaches for clinical and epidemiology research in environmental health. The definitions and implications of the exposome in environmental health sciences remain at a relatively early stage of development, both nationally and internationally. The IHFSC leadership (Jones, Barr, Ziegler) are active in workshops, symposia, and society activities promoting development of exposome-related research. As the IHFSC pursues its mission within HERCULES (Fig G.1) to help operationalize exposome-related research, they will work closely with faculty affiliated with: 1) the Systems Biology Core to enhance utilization and development of exposome-related tools, 2) the Career Development Program to enhance training opportunities in key exposure science technologies and environmental health approaches, 3) the Community Outreach and Engagement Core (COEC) and the Administrative Core to enhance global understanding of the exposome-related concepts and research and their importance in human health and environmental sustainability, and 4) the Pilot Project Program to facilitate translation and integration of exposome-related research tools and concepts into novel and competitive new research projects. This will be done by the IHFSC through 3 major components, universal exposure surveillance (Jones), targeted exposure analyses (Barr), and clinical research services (Ziegler) (Fig G. 1). This builds upon existing bench-to-bedside research in environmental health sciences, anchored by Dr Barr's expert capabilities in exposure science, Dr Jones's universal exposure surveillance method [1], and Dr Ziegler clinical research expertise and links to resources that capitalize on access to well-characterized patients and control subjects. The Core leaders have established local, national and international research leadership in exposure science, quantitative biology, nutrition, and clinical and translational research, have been active in development of exposome-related research and are well- positioned to lead efforts to enhance and facilitate the NIEHS mission in environmental health.

IHFSC的使命是促进对环境暴露于人群和个性化健康应用的基础科学研究的翻译和整合，重点是暴露对随着时间的流逝动态变化的复杂生物系统的影响。这项任务是由大力神的总体主题驱动的，该主题是使用基于Exposome的概念和方法来改善人类健康。 ISHFC的一个关键方面是操作与外界相关的研究，并主要旨在提供对环境健康临床和流行病学研究的工具和研究方法的访问。杂物体在环境健康科学中的定义和含义仍然处于相对较早的发展阶段，无论是在国内还是在国际上。 IHFSC领导力（Jones，Barr，Ziegler）活跃于讲习班，研讨会和社会活动，促进了与宣传体相关研究的发展。 As the IHFSC pursues its mission within HERCULES (Fig G.1) to help operationalize exposome-related research, they will work closely with faculty affiliated with: 1) the Systems Biology Core to enhance utilization and development of exposome-related tools, 2) the Career Development Program to enhance training opportunities in key exposure science technologies and environmental health approaches, 3) the Community Outreach and Engagement Core (COEC) and the Administrative Core to加强了对宣传体相关概念和研究的全球理解及其在人类健康和环境可持续性中的重要性，以及4）试点项目计划，旨在促进与宣传体相关的研究工具和概念的翻译和整合到新颖且竞争性的新研究项目中。这将由IHFSC通过3个主要组成部分，通用暴露监视（琼斯），有针对性的暴露分析（BARR）和临床研究服务（Ziegler）完成（图G. 1）。这是基于Barr博士在曝光科学领域的专家能力，琼斯博士的普遍曝光监视方法[1]以及齐格勒博士的临床研究专业知识的基础上的现有基于环境健康科学的基础研究，并建立在资源上，并将资源与获得良好的患者和控制受试者有关。核心领导者已经在曝光科学，定量生物学，营养以及临床和转化研究方面建立了本地，国家和国际研究领导力，一直积极从事与博览会有关的研究的发展，并在领导着增强和促进NIEHS环境健康任务的努力方面善良。