HERCULES: Health and Exposome Research Center at Emory

HERCULES：埃默里大学健康与暴露研究中心

• 批准号: 8838788
• 负责人: GARY W MILLER
• 金额: $ 119.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838788
• 关键词: Center Core Grants; Climate; Clinical; Collaborations; Communication; Communities; Development; Disease; Environmental Health; Environmental Risk Factor; Exposure to; Extramural Activities; Fostering; Funding; Genetic; Genome; Goals; Health; Health Personnel; Human; Leadership; Logic; Modeling; Monitor; Prevention strategy; Public Health; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Source; Statistical Models; Systems Biology; Toxicology; Translations; Universities; Vision; base; career development; foot; improved; innovation; metabolomics; novel; public health relevance; ranpirnase; treatment strategy

DESCRIPTION (provided by applicant) The vision of the HERCULES P30 (Health and Exposome Research Center: Understanding Lifetime Exposures) is for the exposome to gain equal footing to the genome in clinical and public health settings. The investigators believe that the pursuit of this simple and unifying visin will stimulate discovery, promote collaboration, and enhance communication in Environmental Health Sciences at Emory University. The investigators plan to use the P30 mechanism to create an intellectual climate that fosters innovation, collaboration, and progress. Specifically, they plan to enhance collaborative research at Emory, including increasing extramural funding, serving the local and regional community as a source for information on environmental issues, and to make an impact on the national and global level through cutting-edge research. To do this the investigators propose the following specific aims that align with their theme of using exposome-related concepts and approaches to improve human health: Specific Aim 1: Provide greater access to exposome-related approaches (systems biology, metabolomics, high throughput toxicology, spatial and temporal statistical models) through cores, pilot funding, and research forums. Specific Aim 2: Make major contributions towards the operational definition of the exposome (promoting a culture of team science, pilot funding, pursuing exposome-related research). Specific Aim 3: Provide career development activities around innovative and emerging concepts and approaches related to exposome. Specific Aim 4: Enhance and expand existing relationships with community partners to facilitate communication of the importance of environmental factors in disease using exposome principles. Specific Aim 5: Provide infrastructure and resources to facilitate rapid translation of novel scientific findings ito the development of novel sustainability, prevention or treatment strategies in humans. The organization of the Center is depicted in the HERCULES Logic Model in the strategic vision section. The Executive Committee will be guided by these aims and use the Logic Model to monitor progress of the Center.

描述（由申请人提供） Hercules P30的愿景（健康与外向研究中心：了解终生暴露）是Exposome在临床和公共卫生环境中与基因组相同的基础。调查人员认为，追求这种简单而统一的Visin将刺激埃默里大学环境健康科学的沟通，促进发现，促进合作并加强沟通。 研究人员计划使用P30机制来创造一种促进创新，协作和进步的智力气候。具体来说，他们计划加强埃默里（Emory）的合作研究，包括增加壁外资金，为地方和区域社区服务，作为有关环境问题信息的来源，并通过尖端的研究对国家和全球层面产生影响。为此，调查人员提出了以下特定目的，这些目的与他们使用与杂色组相关的概念和方法的主题相吻合来改善人类健康：特定目的1：通过核心，飞行员资助和研究论坛和研究论坛，提供更多与Exposome相关方法（系统生物学，代谢组学，高吞吐量毒理学，空间和时间统计模型）。 具体目标2：为宣布组的运营定义做出重大贡献（促进团队科学的文化，飞行员资金，从事与外界相关的研究）。 特定目的3：提供围绕与展览组相关的创新和新兴概念和方法提供职业发展活动。 特定目的4：加强与社区伙伴的现有关系，以促进使用剥离原则在疾病中疾病中环境因素的重要性的交流。特定目的5：提供基础设施和资源，以促进新型科学发现的快速转化，以发展人类的新型可持续性，预防或治疗策略的发展。在战略愿景部分的Hercules逻辑模型中描绘了该中心的组织。执行委员会将以这些目标为指导，并使用逻辑模型来监视中心的进度。