Improving the translational value of head and neck cancer patient-in-mouse models

提高头颈癌小鼠模型的转化价值

基本信息

批准号：
10598311
负责人：
RANDALL J KIMPLE
金额：
$ 6.56万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598311
关键词：
Address Affect Age Animal Experimentation Animal Model Biological Biological Models Biology Cancer Model Cetuximab Clinical Clinical Trials Communication DNA Sequence Alteration DNA sequencing Data Educational process of instructing Evolution Generations Genetic Genetic Variation Goals HPV-negative head and neck cancer Head and Neck Cancer Histologic Human Human Biology Human Papillomavirus Immunocompetent Immunocompromised Host Immunotherapy Implant In Situ In Vitro Longevity Malignant Neoplasms Medical Mentors Methodology Methods Minority Graduate Student Modeling Molecular Mus Nose Operative Surgical Procedures Oral Organoids Outcome Parents Pathway interactions Patient Care Patient-Focused Outcomes Patients Physics Research Research Proposals Resistance Role Science Scientist Serial Passage Signal Pathway Site Skin Specimen Squamous Epithelium Squamous cell carcinoma Testing Therapeutic Studies Time Training Translating Treatment outcome Tumor Biology Use Effectiveness anticancer treatment base cancer therapy career cost expectation experience head and neck cancer patient human disease human model implantation improved improved outcome innovation mouse model novel novel therapeutics overtreatment patient derived xenograft model patient response pre-clinical pre-clinical research prevent programs radiation effect radiation response response single-cell RNA sequencing standard care subcutaneous targeted treatment therapy resistant translational model treatment effect treatment response tumor tumor microenvironment tumor-immune system interactions

项目摘要

Project Summary Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. Our goal is to improve the use of mammalian model systems of head and neck cancer to improve treatment outcomes for patients using valid, predictive, well characterized models. The goal of this supplement is to study cancer evolution and therapeutic response with rigorous assessment of tumor biology and genomic alterations to understand how choices made at the time of establishing models impact their relevance over time. Aim 1 will assess the role of heterotopic vs. orthotopic implantation on the therapeutic response and biology of the tumor. Aim 2 will test the concordance of response between patient-derived models and patients. We will use this supplement to support a minority graduate student in the medical physics program to study the effect of radiation on tumor evolution, to provide her with additional training in team science, mentoring, teaching, and communication to support her pursuit of an independent research career.

项目概要源自患者的模型系统通常用于研究肿瘤生物学和测试头部的新疗法和颈部癌症。我们的目标是改进哺乳动物头颈癌模型系统的使用使用有效的、预测性的、特征明确的模型改善患者的治疗结果。此举的目标补充是通过对肿瘤生物学的严格评估来研究癌症的演变和治疗反应和基因组改变，以了解建立模型时所做的选择如何影响它们随着时间的推移相关性。目标 1 将评估异位与原位植入对治疗的作用肿瘤的反应和生物学。目标 2 将测试源自患者的反应之间的一致性模型和患者。我们将使用此补充品来支持医学物理学的少数族裔研究生研究辐射对肿瘤进化的影响的计划，为她提供额外的团队培训科学、指导、教学和交流来支持她追求独立的研究生涯。