BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10594020
• 负责人: Katrin F Chua
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594020
• 关键词: Address; Age; Aging; Area; Automobile Driving; Award; Binding; Biochemical; Biochemistry; Biological Process; Biology; Biology of Aging; Cancer Biology; Cardiovascular Diseases; Cell Aging; Cell physiology; Cells; Chromatin; Chronic Disease; Collaborations; DNA Damage; DNA Sequence; DNA Sequence Alteration; Defect; Diabetes Mellitus; Direct Costs; Disease; Enzymes; Epigenetic Process; Functional disorder; Funding; Future; Gene Expression Regulation; Gene Family; Genes; Genetic Transcription; Genomic Instability; Genomic approach; Genomics; Goals; Grant; Health; Healthcare; Heart Diseases; Heterochromatin; Histone Deacetylase; Histone Deacetylation; Homeostasis; Human; Impairment; Inflammation; Inflammatory; Journals; Lead; Link; Liver diseases; Longevity; Lysine; Malignant Neoplasms; Mediating; Metabolic; Metabolic Diseases; Metabolic stress; Metabolism; Methylation; Molecular; Molecular Biology; Morbidity - disease rate; Musculoskeletal; Nature; Neoplasm Metastasis; Nerve Degeneration; Nuclear; Obesity; Oncogenic; Organism; Orphan; Oxidative Stress; Paper; Pathogenicity; Pathologic; Pathology; Pathway interactions; Physiological; Physiology; Population; Process; Proteins; Proteomics; Publishing; Reader; Regulation; Research; Research Activity; Research Personnel; Resistance; Risk Factors; Role; Scientist; Signal Pathway; Signal Transduction; Sirtuins; Squamous Cell Lung Carcinoma; Stress; System; Therapeutic; Tissues; Transcript; Translating; United States National Institutes of Health; Universities; Untranslated RNA; Veterans; Work; age related; aged; career; epigenomics; gene network; histone methyltransferase; immunosenescence; improved; in vivo; insight; interest; member; military veteran; mouse model; muscle regeneration; neoplastic; non-alcoholic fatty liver disease; novel; novel therapeutic intervention; patient population; prevent; professor; programs; senescence; stem cell biology; structural biology; targeted treatment; telomere; tumor growth

Aging is the greatest risk factor for many chronic diseases including cancer, neurodegeneration, diabetes, and heart disease. Currently, roughly half of the VA population is aged 65+ years, and in the next ten years, more than 3 million of these veterans are expected to be over 75. Thus, studying genes that regulate aging and aging-associated pathologies is critically important for biomedical advancements to benefit veterans’ health. This research program investigates two such genes, SIRT6 and SIRT7, which are “master regulators” of many changes in aging tissues, such as DNA damage, metabolic and oxidative stress, cellular senescence, and inflammation. Our projects study how decreased activity of these genes may contribute to pathologies in cardiovascular and liver disease, diabetes, obesity, and many cancers, and how activating these genes could protect against these pathologies. By identifying pathways that can be targeted for therapy, this research can directly impact the health of the Veteran population. .

衰老是许多慢性疾病的最大危险因素，包括癌症、神经退行性疾病、糖尿病、 目前，大约一半的退伍军人事务部人口年龄在 65 岁以上，并且在未来十年内， 其中超过 300 万退伍军人预计年龄超过 75 岁。因此，研究调节衰老的基因 与衰老相关的病理对于生物医学的进步至关重要，有利于退伍军人的健康 该研究计划研究了两个这样的基因：SIRT6 和 SIRT7，它们是“主控基因”。 衰老组织中许多变化的调节者，例如 DNA 损伤、代谢和氧化应激， 我们的项目研究这些基因的活性降低如何可能。 导致心血管和肝脏疾病、糖尿病、肥胖和许多癌症的病理，以及如何 通过识别可针对的途径，激活这些基因可以预防这些疾病。 对于治疗而言，这项研究可以直接影响退伍军人群体的健康。 。