Smartphone-based mindfulness intervention for reducing stressrelated CVD risk

基于智能手机的正念干预可降低压力相关的心血管疾病风险

基本信息

批准号：
10593307
负责人：
THOMAS WILSON KAMARCK
金额：
$ 27.83万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-16 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10593307
关键词：
Acceleration Acute Address Aftercare Age Age Factors Ambulatory Monitoring Atherosclerosis Behavioral Benchmarking Biological Markers Blood Pressure Cardiac Cardiovascular Diseases Cardiovascular system Cellular Phone Chronic Clinical Clinical Trials Computer Models Conflict (Psychology)Data Data Correlations Detection Development Effectiveness Elderly Enrollment Environment Event Exhibits Experimental Designs Exposure to Goals Health Hypertension Intervention Laboratories Life Life Stress Link Literature Measures Mindfulness Training Modeling Outcome Participant Phase II Clinical Trials Physiological Population Psyche structure Psychosocial Stress Public Health Randomized Randomized, Controlled Trials Recording of previous events Recurrence Reporting Research Risk Risk Factors Sampling Source Standardization Stress Testing Time Training Training Programs Treatment/Psychosocial Effects Work acute stress adaptive intervention cardiovascular disorder risk cohort design disorder risk mHealth middle age mindfulness mindfulness intervention mortality occupational stress perceived stress portability pre-clinical programs recruit response satisfaction side effect social stress reactivity stress reduction stressor tool treatment as usual treatment duration treatment effect usual care arm

项目摘要

SUMMARY: Smartphone-based mindfulness intervention for reducing stress-related CVD risk Chronic psychosocial stress has been shown to be associated with increased risk for cardiovascular disease (CVD), and exaggerated stress-related cardiovascular reactivity (CVR) has also been linked with elevated CVD risk. Most of the evidence in these literatures is based upon correlational data to date. Progress in characterizing and ameliorating these effects requires the development of standardized intervention tools designed to alter stress exposure and reactivity. Mobile health interventions may provide a useful approach to this problem. We have identified two specific daily life measures of psychosocial stress and stress reactivity, measured by ambulatory monitoring, that are associated with markers of subclinical atherosclerosis. We have also developed a smartphone-based mindfulness training program that appears to produce significant reductions in related measures of daily life stress and acute stress-related physiological responding. The current study is designed to examine whether this mobile health intervention is feasible and effective in addressing the stress-related targets we have identified, in a population selected for vulnerability to stress and to CVD. We will examine whether additional practice prompts that are presented during daily life (in the spirit of “Just-in-Time Adaptive Interventions” or JITAIs) increase the magnitude or duration of treatment effects, and we will also explore whether we can develop a model to assist us in identifying the circumstances in which automated prompting may be fruitfully employed as part of this treatment. The goal is to produce a scalable mobile health intervention that can be shown to reduce progression of preclinical CVD as part of a subsequent Phase 2 clinical trial. RELEVANCE: Developing interventions for reducing the effects of psychosocial stress on cardiovascular disease is of critical importance for public health.

概括：基于智能手机的正念干预可降低与压力相关的心血管疾病风险慢性社会心理压力已被证明与心血管疾病风险增加有关 (CVD)，过度的压力相关心血管反应性 (CVR) 也与 CVD 升高有关这些文献中的大部分证据都是基于迄今为止的相关数据。改善这些影响需要开发标准化干预工具，旨在改变压力暴露和反应性可能为解决这个问题提供有用的方法。已经确定了心理社会压力和压力反应的两种具体日常生活测量方法，通过以下方法测量我们还开发了与亚临床动脉粥样硬化标志物相关的动态监测。一项基于智能手机的正念训练计划，似乎可以显着减少相关的目前的研究旨在测量日常生活压力和急性压力相关的生理反应。检查这种移动健康干预措施在解决与压力相关的目标方面是否可行且有效我们已经确定，在选定的易受压力和心血管疾病影响的人群中，我们将检查是否存在这种情况。日常生活中出现的额外练习提示（本着“及时自适应”的精神）干预措施”或 JITAI）会增加治疗效果的程度或持续时间，我们还将探讨是否我们可以开发一个模型来帮助我们识别自动提示可能出现的情况作为这种治疗的一部分，我们的目标是产生一种可扩展的移动健康干预措施。作为后续 2 期临床试验的一部分，可以证明可以减少临床前 CVD 的进展。关联：制定干预措施以减少社会心理压力对心血管疾病的影响至关重要对公共卫生的重要性。