Addressing Hazardous and Harmful Alcohol use Through an Adapted CBT Sleep Intervention

通过适当的 CBT 睡眠干预措施解决危险和有害的酒精使用问题

• 批准号: 10592944
• 负责人: Wilfred R Pigeon
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592944
• 关键词: Address; Adult; Aftercare; Alcohol abuse; Alcohol consumption; Alcohols; Award; Back; Behavioral; Bypass; Clinical; Cognitive Therapy; Communities; Data; Development; Diagnostic; Education; Enrollment; Feasibility Studies; Feeling suicidal; Future; Glean; Individual; Intervention; Manuals; Measurement; Measures; Mental Depression; Mental Health; Methods; Moods; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Participant; Patient Recruitments; Patient Self-Report; Patients; Pattern; Phase; Pilot Projects; Population; Post-Traumatic Stress Disorders; Preparation; Prevention trial; Procedures; Prognosis; Public Health; Recovery; Research; Research Design; Risk Factors; Sampling; Self Medication; Severities; Sleep; Sleep Disorders; Sleeplessness; Societies; Substance Use Disorder; Telephone; Testing; alcohol abuse therapy; alcohol effect; alcohol misuse; alcohol use disorder; associated symptom; brief intervention; burden of illness; cognitive testing; comorbidity; comparison intervention; cost; depressive symptoms; design; diagnostic criteria; drinking; experience; follow up assessment; follow-up; improved; improvement on sleep; indexing; intervention effect; medical specialties; modifiable risk; mortality; open label; physical conditioning; programs; prospective; randomized trial; recruit; response; social stigma; substance abuse prevention; suicidal behavior; symptomatic improvement; telephone delivery; therapy design; therapy development; timeline

Project Summary/Abstract Drinking problems and sleep problems each cause significant loss at individual and societal levels. Insomnia in particular is highly prevalent in patients with alcohol use disorder, is prospectively associated with the development of alcohol use disorder and contributes to poorer recovery prognosis following alcohol treatments. Insomnia, therefore, represents a modifiable risk factor for negative outcomes associated with alcohol use along the full continuum of alcohol use problems. Accordingly, the project proposes to improve sleep with an insomnia intervention tailored to individuals who meet widely accepted definitions for hazardous alcohol use as well as diagnostic criteria for insomnia disorder. This is a treatment development study that will adapt cognitive behavioral therapy for insomnia for adults engaged in hazardous use of alcohol. We propose an iterative approach to development, refinement, and preliminary examination of the utility of a telephone-delivered, 4-session version of cognitive behavioral therapy for insomnia adapted to hazardous alcohol users. The project will begin with a small, open label pilot to develop and refine procedures for administering the intervention. Then, we will conduct a small, randomized trial comparing the intervention to a sleep and alcohol education control condition. As this is a treatment development award, we will assess a number of intervention and study design feasibility domains in preparation for designing a larger study. We will also assess the effects of the intervention on alcohol use, sleep and mood by measuring these outcomes at baseline, post-treatment, and at 3- and 6-month follow up assessments. In sum, this proposal is the first step in a program of research that intends to use sleep as a lever to alter the course of hazardous alcohol use. Here, the first step is to adapt an already successful insomnia intervention to a unique population and conduct a preliminary test of that interventions’ acceptability to patients, fidelity by therapists, and effects on drinking, sleep and mood. If study results are promising, we will use these data and information gleaned about the study methods to pursue the next phase of research: designing and conducting a definitive study to test our insomnia intervention’s capacity to decrease alcohol use and modify the course of hazardous alcohol use.

项目概要/摘要 饮酒问题和睡眠问题都会对失眠造成个人和社会层面的重大损失。 特别是在酒精使用障碍患者中非常普遍，预计与 酒精使用障碍的发展，并导致酒精治疗后恢复预后较差。 因此，失眠是与饮酒相关的负面结果的一个可改变的风险因素 沿着酒精使用问题的整个连续过程。 因此，该项目建议通过针对以下人群的失眠干预措施来改善睡眠： 符合广泛接受的有害饮酒定义以及失眠症诊断标准。 这是一项治疗开发研究，将采用认知行为疗法治疗成人失眠 我们提出了一种迭代方法来开发、完善和处理酒精的危险使用。 电话传递的 4 次认知行为疗法的效用的初步检验 针对失眠适应危险酒精使用者。 该项目将从一个小型、开放标签试点开始，以开发和完善管理程序 然后，我们将进行一项小型随机试验，将干预措施与睡眠和酒精进行比较。 由于这是一项治疗发展奖，我们将评估一些干预措施。 并研究设计可行性领域，为设计更大规模的研究做准备。我们还将评估效果。 通过在基线、治疗后测量这些结果来评估对饮酒、睡眠和情绪的干预， 以及 3 个月和 6 个月的后续评估。 总而言之，这项提案是一项研究计划的第一步，该计划旨在利用睡眠作为杠杆来改变 在这里，第一步是调整已经成功的失眠干预措施。 一个独特的人群，并对干预措施对患者的可接受性、保真度进行初步测试 治疗师以及对饮酒、睡眠和情绪的影响如果研究结果有希望，我们将使用这些数据并进行研究。 收集有关研究方法的信息以进行下一阶段的研究：设计和进行 一项权威研究，旨在测试我们的失眠干预措施减少饮酒和改变睡眠过程的能力 危险的酒精使用。