The Psychoneuroimmunology of Insomnia: Response to a Vaccine Challenge

失眠的心理神经免疫学：对疫苗挑战的反应

• 批准号: 7473950
• 负责人: Wilfred R Pigeon
• 金额: $ 13万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7473950
• 关键词: Affect; Age; Aging; Antibodies; Antibody Formation; Arousal; Biometry; Blood; Cardiovascular Diseases; Chronic Insomnia; Classification; Clinical; Cognitive; Columbidae; Communities; Condition; Consumption; Daily; Development; Diagnostic; Disease; Enrollment; Epidemiologic Studies; Fatigue; Female; Fostering; Functional disorder; Generations; Goals; HPSE gene; Health; Health Status; Healthcare; Heart Rate; Hepatitis B; Hepatitis B Vaccination; Hepatitis B Vaccines; Hypertension; Immune response; Immune system; Immunity; Immunocompetence; Impaired cognition; Incidence; Individual; International; Investigation; K-Series Research Career Programs; Longevity; Major Depressive Disorder; Measures; Medical; Minority; Morbidity - disease rate; Obstructive Sleep Apnea; Organ; Outcome; Pathway interactions; Patient Self-Report; Patients; Physiological; Population; Premenopause; Prevalence; Process; Program Development; Psychoneuroimmunology; Purpose; Quality of life; Rate; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Sampling; Sleep; Sleep Deprivation; Sleep Disorders; Sleeplessness; Structure; Substance abuse problem; Symptoms; Testing; Training; Training Programs; Treatment Protocols; Upper arm; Vaccination; Vaccines; Woman; aged; base; blood glucose regulation; career; design; diaries; disease classification; disturbance in affect; hypothalamic-pituitary-adrenal axis; immune function; indexing; interest; men; mortality; programs; research study; response; size; skills

DESCRIPTION (provided by applicant): Despite its extraordinary prevalence, increasing incidence across the lifespan, and consequences, the pathophysiology of insomnia and, specifically, the pathways by which morbidity risk is conferred, have been relatively unstudied. The specific goal for this K-Award is to engage in a program of training and developing research that will allow the applicant to blend psychoneuroimmunology (PNI) and insomnia research, and to foster a program of investigation that seeks to delineate how two perpetuating processes of insomnia (hyperarousal and homeostatic dysregulation) affect health outcomes in general, and immune function in particular. The development program detailed in this application is structured to provide the applicant training in PNI, biostatistics, grantsmanship, the ethical conduct of research, and how one engages with minority communities. The specific aim for the proposed research project is to ascertain whether chronic insomnia is associated with a blunted adaptive immune response to an experimental challenge. This study uses a two-group, parallel arm study of 50 pre-menopausal female subjects aged 30-50 (25 with chronic insomnia [Pis] and 25 good sleepers [GSs]) to assess whether insomnia is associated with a blunted antibody response to a Hepatitis B vaccine challenge. Each subject will receive the established 3-part vaccine regimen, with blood draws to determine protective antibody levels following each administration. The central hypothesis to be tested is that Pis will have lower antibody titers (a continuous measure) and lower sero-conversion rates (a dichotomous measure) than GSs following the 1st and 2nd vaccinations. In addition to the specific assessment of immunocompetence, sleep continuity will be assessed daily with sleep diaries; health status will be assessed weekly with symptom checklists. These assessments will occur over a three month period. The value of the proposed career training program and the related research resides in the development of the PI as an individual with the skills and background to bridge traditionally separate domains of investigation, and its capacity to operationally define immunocompetence in a manner' that is likely to be directly related to health outcomes, to do so in a clinical population believed to be at risk for significant medical morbidity, and with a condition that becomes increasingly pronounced with aging.

描述（由申请人提供）：尽管失眠非常普遍，并且在整个生命周期中发病率不断增加，而且造成的后果也不断增加，但失眠的病理生理学，特别是导致发病风险的途径，相对而言尚未得到研究。该 K 奖的具体目标是参与一项培训和开发研究计划，使申请人能够将心理神经免疫学 (PNI) 和失眠研究结合起来，并促进一项调查计划，旨在描述失眠的两个永久过程如何发生。失眠（过度警觉和体内平衡失调）通常会影响健康结果，尤其是免疫功能。本申请中详细介绍的开发计划旨在为申请人提供 PNI、生物统计学、资助、研究道德行为以及如何与少数群体互动等方面的培训。拟议研究项目的具体目的是确定慢性失眠是否与对实验挑战的适应性免疫反应迟钝有关。本研究对 50 名 30-50 岁的绝经前女性受试者（25 名患有慢性失眠 [Pis] 和 25 名睡眠良好者 [GSs]）进行了两组平行研究，以评估失眠是否与抗体反应减弱有关。乙型肝炎疫苗挑战。每个受试者将接受既定的三部分疫苗方案，并在每次接种后抽血以确定保护性抗体水平。要测试的中心假设是，在第一次和第二次疫苗接种后，与 GS 相比，Pi 的抗体滴度（连续测量）和血清转化率（二分测量）较低。除了免疫功能的具体评估外，还将通过睡眠日记每天评估睡眠连续性；每周将使用症状检查表评估健康状况。这些评估将在三个月内进行。拟议的职业培训计划和相关研究的价值在于将 PI 培养为具有技能和背景的个人，以弥合传统上独立的研究领域，并以一种可能的方式在操作上定义免疫能力的能力。与健康结果直接相关，在被认为具有重大医疗发病风险的临床人群中这样做，并且这种情况随着年龄的增长而变得越来越明显。