Data Core

数据核心

基本信息

批准号：
10262850
负责人：
MARK Andrew ESPELAND
金额：
$ 30.78万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10262850
关键词：
Adult African American Alzheimer&apos s Disease Alzheimer&apos s disease risk American Applications Grants Archives Automobile Driving Bioinformatics Biomedical Computing Biometry Blood Vessels Brain Capsicum Clinical Trials Cognition Cognitive Collaborations Collection Communication Research Communities Consultations Data Data Analyses Data Management Resources Data Reporting Databases Development Disease Education Educational workshop Ensure Family Fostering Funding Genetic Gerontology Geroscience Goals Health Professional Image Analysis Individual Infrastructure Interdisciplinary Study Interest Group Investments Magnetic Resonance Imaging Manuscripts Measurement Measures Mentors Metabolic Methodology Methods Mission Modeling Multicenter Studies Pathogenesis Pathway interactions Patients Preparation Prevention Prevention strategy Productivity Protocols documentation Publications Recording of previous events Reporting Research Research Design Research Infrastructure Research Personnel Resources Role Science Secure Services Training United States National Institutes of Health Vision Work analytical method biomathematics career collaborative environment data archive data exchange data infrastructure data management data quality data resource experience forest improved meetings novel novel strategies programs quality assurance research and development success therapeutic development webinar

项目摘要

Data Management and Statistical Core – Project Summary The mission of the Data Management and Statistical Core (DMSC) is to promote excellence in the Wake Forest ADRC by providing outstanding data management, biomedical computing, and analytical support to ADRC investigators and affiliates. The Wake Forest ADRC has four overarching aims: 1) to establish a comprehensive integrated research infrastructure at Wake Forest focused on identifying the causes of Alzheimer’s disease and related disorders (ADRD) and potential strategies for prevention and treatment; 2) to develop within this infrastructure specialized resources to facilitate research on the role of metabolic and vascular pathways in AD pathogenesis and on targeted development of therapeutic strategies; 3) to optimize the participation of African American adults in research and educational programs to better understand and treat the causes underlying the increased risk of ADRD in these individuals; and 4) to provide education regarding ADRD to researchers, health professionals, patients and their families, and the community at large. To accomplish these objectives, the DMSC will: 1) provide and maintain state-of-the-art resources for data management, study management, and reporting to ensure the highest data quality and study integrity and to increase the efficiency and impact of ADRC research; 2) provide expertise and collaboration in study design, clinical trials, biostatistics and other analytical sciences (including measurement, image analysis, modelling, statistical genetics, bioinformatics, and biomathematics) for Wake Forest ADRC-affiliated projects; 3) develop and maintain efficient and secure platforms for the exchange of data within the Wake Forest ADRC and with NACC, NCRAD, other ADRCs, and ADRD researchers; 4) mine our extensive library of data from major studies of cognition and AD to facilitate efficient study design, provide a platform for pooled analyses, and provide resources to facilitate the development of ADRD researchers, and 5) provide a bridge between ADRD and gerontology/geroscience researchers in the ADRC and the Pepper Older American Independence Center (OAIC) to leverage existing expertise and resources and nurture novel approaches. The DMSC has a breadth of relevant experience, a diverse analytical team, a strong collaborative environment, many extant resources for study management, an extensive archive of cognitive data from many major studies, and a proven robust data management infrastructure. These are the essential facets and notable strengths of our ADRC.

数据管理和统计核心 - 项目摘要数据管理和统计核心 (DMSC) 的使命是促进 Wake 领域的卓越发展 Forest ADRC 通过提供出色的数据管理、生物医学计算和分析支持 ADRC 调查人员和附属机构。维克森林 ADRC 有四个总体目标：1) 建立一个维克森林大学全面综合的研究基础设施致力于查明问题的原因阿尔茨海默病及相关疾病 (ADRD) 和潜在的预防和治疗策略 2) 在此基础设施内开发专门资源，以促进代谢和代谢作用的研究 AD发病机制中的血管通路和治疗策略的针对性开发3）优化；非裔美国成年人参与研究和教育计划，以更好地理解和治疗这些人 ADRD 风险增加的原因；4) 提供教育；向研究人员、卫生专业人员、患者及其家人以及整个社区传达有关 ADRD 的信息。为了实现这些目标，DMSC 将：1) 提供并维护最先进的数据资源管理、研究管理和报告，以确保最高的数据质量和研究完整性，并提高 ADRC 研究的效率和影响力；2）提供研究设计方面的专业知识和协作，临床试验、生物统计学和其他分析科学（包括测量、图像分析、建模、 3）开发维护高效、安全的平台，以便在维克森林 ADRC 内部以及与 NACC、NCRAD、其他 ADRC 和 ADRD 研究人员 4) 挖掘我们来自主要专业的广泛数据库；认知和AD研究，以促进有效的研究设计，提供汇总分析平台，以及提供资源以促进 ADRD 研究人员的发展，以及 5）在 ADRD 之间搭建桥梁 ADRC 和 Pepper 美国老年人独立中心的老年学/老年科学研究人员 (OAIC) 利用现有的专业知识和资源并培育新颖的方法。相关经验、多元化的分析团队、强大的协作环境、许多现有资源用于研究管理，来自许多主要研究的认知数据的广泛档案，以及经过验证的稳健的这些是我们 ADRC 的重要方面和显着优势。