Kansas City - New Vaccine Surveillance Network (KC-NVSN)

堪萨斯城 - 新疫苗监测网络 (KC-NVSN)

• 批准号: 9206684
• 负责人: Christopher Harrison
• 金额: $ 21.43万
• 依托单位: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9206684
• 关键词: Kansas; City; New; Vaccine; Surveillance

Project Summary: The Kansas City-New Vaccine Surveillance Network (KC-NVSN) program was established in 2009 to conduct population-based, laboratory-confirmed, active surveillance of acute gastroenteritis (AGE) illness in children seeking care at Children's Mercy Hospital, in Kansas City (KC), MO. The program was subsequently expanded in 2015 to include hospitalized ARI children in inpatient (IP) settings. In the current proposal, the KC-NVSN program seeks to continue the existing pediatric AGE IP and outpatient (OP) surveillance in the six county KC metropolitan area and ARI IP surveillance in Jackson County, MO. In addition, we will expand ARI surveillance to OP from Jackson County visiting the main CMH emergency department. Age and time matched healthy control children will also be enrolled. Eligible children visiting or admitted to our hospital system as defined above will be enrolled using permission and assent forms approved by the institutional review board (IRB) of CMH. We will conduct parent interviews, collect medical chart data and retrieve hard copies of vaccine information for influenza and rotavirus from enrolled children. Clinical specimens collected from children will be tested for rotavirus (and other GI pathogens, e.g. norovirus in proposed subprojects) in stool and 22 respiratory pathogens from respiratory specimen including specific influenza subtypes and other non-influenza viruses, such as RSV, EV-D68 etc. The data collected from the KC-NVSN program will provide population-based estimates to address the following specific aims: 1. To assess vaccine effectiveness (VE) in preventing medically attended rotavirus and influenza illness by the test-negative case-control study design using laboratory confirmed testing among enrolled children. 2. To assess the burden of select AGE pathogens and non-influenza viral pathogens, including respiratory syncytial virus and EV-D68 among enrolled children. The KC-NVSN program will provide data to be combined with other geographically diverse sites to estimate the national incidence, burden, and etiology of community-acquired AGE and ARI. The VE for rotavirus and seasonal influenza vaccinations will be calculated to measure the impact of vaccination. This network will also address several important scientific questions related to natural history of pediatric infectious diseases, transmission dynamics, impact of vaccine on targeted and vulnerable population and factors that influence vaccine effectiveness. The surveillance data generated from this network will provide timely and highly useful data to inform public health measures and pediatric vaccine-related policies aimed at controlling AGE and ARI in US children.

项目摘要： 堪萨斯城市新疫苗监视网络（KC-NVSN）计划于2009年建立 儿童急性胃炎（年龄）疾病的基于人群的实验室确认，主动监测 在密苏里州堪萨斯城（KC）的儿童慈悲医院寻求护理。该程序随后扩展了 2015年，将住院的ARI儿童包括住院（IP）设置。 在当前的建议中，KC-NVSN计划试图继续现有的儿科年龄IP和门诊病人 （OP）在密苏里州杰克逊县的六个县KC大都会地区和ARI IP监视的监视。在 此外，我们将从杰克逊县（Jackson County）访问主要CMH紧急情况下将ARI监视扩展到OP 部门。年龄和时间匹配的健康对照儿童也将入学。符合条件的儿童参观或 按照上述定义的医院系统接纳将使用许可和同意表格批准招募 由CMH的机构审查委员会（IRB）。我们将进行家长访谈，收集医疗图表数据 并从注册儿童中检索流感和轮状病毒的疫苗信息的硬副本。临床 从儿童那里收集的标本将进行轮状病毒病毒（以及其他GI病原体，例如诺如病毒 粪便中提出的supprojects）和22种来自呼吸标本的呼吸道病原体 流感亚型和其他非影响的病毒，例如RSV，EV-D68等。 KC-NVSN计划将提供基于人群的估计，以解决以下具体目标： 1。评估疫苗有效性（VE）预防医学上参加轮状病毒和流感的疫苗 通过实验室确认测试的测试阴性病例对照研究设计的疾病 注册的孩子。 2。评估某些年龄病原体和非炎者病毒病原体的负担，包括 注册儿童中的呼吸综合病毒和EV-D68。 KC-NVSN计划将提供数据与其他地理上不同站点相结合的数据，以估算 社区获得年龄和ARI的国家发病率，负担和病因。轮状病毒和 将计算季节性流感疫苗接种以衡量疫苗接种的影响。这个网络也将 解决与小儿传染病自然史有关的几个重要科学问题， 传播动态，疫苗对靶向和脆弱人群的影响以及影响的因素 疫苗有效性。该网络生成的监视数据将提供及时且非常有用 为旨在控制年龄和ARI的公共卫生措施和小儿疫苗相关政策提供信息的数据 在美国的孩子。