Center of Excellence for Cancer Research, Training and Community Service

癌症研究、培训和社区服务卓越中心

基本信息

批准号：
9002855
负责人：
KARAM F.A. SOLIMAN
金额：
$ 108.96万
依托单位：
FLORIDA AGRICULTURAL AND MECHANICAL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-16 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9002855
关键词：
Address Affect African American Antineoplastic Agents Area Behavioral Research Biological Biological Assay Biomedical Research Breast Cell Survival Cessation of life Collaborations Communities Community Outreach Community Services County Detection Development Disadvantaged Doctor of Philosophy Early Diagnosis Educational workshop Environment Ethnic group Evaluation Faculty Female Florida Fostering Funding Goals Grant Health Hypoxia Inequality Information Dissemination Interdisciplinary Study International Journals Knowledge Link Lung Mainstreaming Malignant Neoplasms Malignant neoplasm of lung Metabolism Minority Minority Graduate Student Mission Morbidity - disease rate Nanotechnology Outreach Research Pharmacologic Substance Pharmacy facility Population Positioning Attribute Prevention Prostate Proteomics Publications Publishing Quality of Care Race Regulation Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Proposals Research Support Research Training Resources Science Secure Series Services Students Training Underrepresented Groups Underrepresented Minority United States National Institutes of Health Universities Validation Woman Work Writing analog anti-cancer therapeutic anticancer research base biomedical scientist cancer cell cancer health disparity cancer prevention career college community based participatory research disadvantaged population experience faculty mentor faculty support graduate student health disparity improved innovation interest malignant breast neoplasm meetings member minority health minority scientist mortality multidisciplinary nanocarrier novel outreach prevent programs racial difference skills socioeconomic disadvantage socioeconomics specific biomarkers

项目摘要

DESCRIPTION (provided by applicant): Florida A&M University (FAMU) College of Pharmacy and Pharmaceutical Sciences (COPPS) proposes the establishment of an Exploratory Center of Excellence (COE) in the area of Cancer Research, Training and Community Service (CRTCS). African-Americans experience the highest mortality rates associated with most cancer (breast, lung, prostate, etc.) deaths despite decreases in morbidity rates for all other racial and ethnic groups since early 1990. Health disparities are closely related to underlying socioeconomic inequalities and have been linked to racial differences among cancer mortality which presents major challenges across the entire spectrum of cancer prevention, early detection, and access to high quality care for disadvantage and underrepresented groups. The overall goal and objective of the COE CRTCS will consist of researchers focusing on developing innovative cancer research (breast and lung) abnormalities utilizing an interdisciplinary and synergistic approach toward addressing some of the most significant health consequences in minority and socioeconomic disadvantaged populations. This will address novel and innovative approaches to treating and preventing breast and lung cancer. The administrative; biomedical and behavioral research; research training/educational and community engagement/outreach cores will enable the COE CRTCS to accomplish the proposed initiatives. The specific aims of the COE CRTCS are to: 1) Develop detailed innovative research plans that will address specific cancer (breast and lung) health issues that disproportionately impact African-American; 2) Develop a research team conducting cancer research; 3) Train minority PhD graduate students in health disparities research affecting disadvantage and minority populations; 4) Increase the number of minority scientists engaged in biomedical and behavioral research; 5) Establish and enhance community outreach and information dissemination activities that will increase prevention efforts and foster early detection towards reducing breast cancer in African-American women (Leon and Gadsden County, Florida); 6) Establish and expand partnerships with community engagement/outreach organizations toward addressing and conducting minority health and other health disparities issues; and 7) Position FAMU to become more competitive in securing mainstream funding in biomedical and behavioral research support and addressing minority health disparities. The support of this application will promote minority health and aid i the elimination of health disparities as it relates to breast (among African-American females) and lung cancer (among minorities).

描述（由申请人提供）：佛罗里达州A＆M大学（FAMU）药学与药学学院（COPPS）建议在癌症研究，培训和社区服务（CRTCS）领域建立一个卓越探索中心（COE）。自1990年初以来，所有其他种族和族裔的发病率降低，非裔美国人的死亡率（乳腺癌，肺，前列腺等）的死亡人数降低，但死亡人数最高，自1990年初以来所有其他种族和族裔群体的发病率降低。健康差异与基本的社会经济不平等问题密切相关，并且与癌症范围内的种族差异相关，这些疾病与癌症的良好范围相关，这些疾病与癌症的良好范围有关，这些疾病的质量范围均与癌症范围的范围相关，而癌症的范围则与癌症相关，那么癌症的质量及其范围是癌症的范围。缺点和代表性不足的群体。 COE CRTC的总体目标和目标将包括专注于开发创新癌症研究（乳腺癌和肺部）异常的研究人员，利用跨学科和协同方法来解决少数群体和社会经济经济上的违法人群中最重要的健康后果。这将介绍治疗和预防乳腺癌和肺癌的新颖和创新方法。行政生物医学和行为研究；研究培训/教育和社区参与/推广核心将使COE CRTC能够完成拟议的计划。 COE CRTC的具体目的是：1）制定详细的创新研究计划，这些计划将解决特定的癌症（乳腺癌和肺）健康问题，这些问题不成比例地影响非裔美国人； 2）发展一个进行癌症研究的研究团队； 3）培训少数族裔博士研究生的健康差异研究，影响不利和少数民族； 4）增加从事生物医学和行为研究的少数族裔科学家的数量； 5）建立和增强社区外展和信息传播活动，以增加预防努力并促进早期检测，以减少非裔美国妇女（佛罗里达州莱昂和加兹登县）的乳腺癌； 6）与社区参与/外展组织建立和扩展伙伴关系，以解决和解决少数群体健康和其他健康差异问题； 7）位置FAMU在获得生物医学和行为研究支持和解决少数族裔健康差异方面的主流资金方面变得更有竞争力。该应用的支持将促进少数民族的健康，并帮助消除与乳房（在非裔美国女性中）和肺癌（少数民族中）有关的健康差异。

项目成果

期刊论文数量（73）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bioactivity-Guided Isolation of Neuritogenic Factor from the Seeds of the Gac Plant (Momordica cochinchinensis).

DOI：
10.1155/2018/8953958
发表时间：
2018
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
0
作者：
Mazzio E;Badisa R;Eyunni S;Ablordeppey S;George B;Soliman KFA
通讯作者：
Soliman KFA

Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.

DOI：
10.1371/journal.pone.0089919
发表时间：
2014
期刊：
PloS one
影响因子：
3.7
作者：
Godugu C;Patel AR;Doddapaneni R;Somagoni J;Singh M
通讯作者：
Singh M

Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances.

“新洛芬”（一种布洛芬的刚性类似物）的合成，举例说明了改变药物物质 3-D 拓扑结构的合成方法。

DOI：
10.1039/c6ob01351a
发表时间：
2016
期刊：
Organic & biomolecular chemistry
影响因子：
3.2
作者：
Ramsubhag,RonR;Massaro,ChelseaL;Dadich,ChristinaM;Janeczek,AndrewJ;Hoang,TungT;Mazzio,ElizabethA;Eyunni,Suresh;Soliman,KaramFA;Dudley,GregoryB
通讯作者：
Dudley,GregoryB

The attenuating effects of 1,2,3,4,6 penta-O-galloyl-β-d-glucose on inflammatory cytokines release from activated BV-2 microglial cells.