Training Program in Translational Cardiovascular Research and Entrepreneurship

转化心血管研究和创业培训计划

• 批准号: 9035429
• 负责人: Jose S Jalife
• 金额: $ 19.58万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9035429
• 关键词: Cardiovascular system; Entrepreneurship; Research; Training Programs

 DESCRIPTION (provided by applicant): This proposal seeks to develop a new training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. Therefore, the mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the level of the molecule, through the cellular, intact tissue and animal models, to the bedside, with the ultimate goal of improving therapy for patients. Since this is a pre-doctoral training experience taking place during the last two years of the PhD program after preliminary examination, the emphasis is on an advanced didactic program and independent research. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic and preclinical cardiovascular research and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive experience in translational research training. The added benefit is that it will also prepare students for the diversity of scientific careers available to and typially pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The translational CVRE program will attract students from laboratories across the Frankel Cardiovascular Center faculty membership, the medical school wide Program in Biomedical Sciences, and the School of Engineering. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be the "leaders and best" at taking basic research discoveries and being capable of directing their path to the clinic. (End of Abstract)

 描述（由应用程序提供）：该提案旨在制定密歇根大学转化心血管研究与企业家（CVRE）的新培训计划。心血管疾病是全球死亡的主要原因。因此，该计划的任务是培训下一代的博士学位科学家在心血管研究中寻求职业在伦理发展和应用中，从分子的水平，通过细胞，完整的组织和动物模型来培训从分子的水平到床边，并将其改善患者治疗的最终目标。因为这是预期的 在初步考试后的博士学位课程的最后两年中，进行了培训经验，重点是先进的教学计划和独立研究。拟议的培训计划故意旨在解决在转化心血管研究的关键领域的年轻基础科学家和博士前学生的差距，例如临床前研究设计，药物发现，设备/治疗的开发，优化和测试，企业家精神和法规合规性。该计划的跨学科和国际认可的学院提供了一个出色的培训环境，其中包括跨越遗传，分子，细胞，系统，工程，工程和临床研究的最先进的设施和技术，并进行了血管疾病和心脏疾病的临床研究。通过利用密歇根大学的基础和临床前心血管研究和独特的学术资源的现有优势，我们将不仅在最先进的生物医学研究中培训学生，而且还将将系统生物学应用于临床前测试，导航监管法规合规性和企业家。因此，该计划为学生提供了翻译研究培训中独特的全面和身临其境的体验。额外的好处是，它还将为学生做好准备的科学职业，并通常由年轻科学家提供，包括学术研究，初创公司，生物技术以及大型制药公司和设备公司。翻译CVRE计划将吸引来自弗兰克尔心血管中心教职员工的实验室的学生，生物医学科学的医学院广泛计划和工程学院。通过将学生置于基本心血管研究，生物医学工程和心血管医学之间的界面，我们希望更好地准备下一代博士学位科学家，成为“领导者和最佳”，以吸引基础研究发现，并能够将他们的道路引导到诊所。 （抽象的结尾）