Improving round window stimulation via moldable coupler and impedance modeling

通过可塑耦合器和阻抗建模改善圆窗刺激

• 批准号: 9250400
• 负责人: Darcy Frear
• 金额: $ 3.61万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2018-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9250400
• 关键词: Accounting; Acoustics; Affect; Air; Anatomy; Area; Basilar Membrane; Bone Conduction; Bypass; Clinical; Cochlea; Collection; Complement; Computer Simulation; Conductive hearing loss; Conventional Surgery; Coupling; Data; Devices; Dimensions; Ear; Ear ossicles; Effectiveness; Esthesia; Eye; Goals; Hearing; Hearing Aids; Histologic; Human; Implant; Individual; Knowledge; Labyrinth; Lasers; Lead; Left; Life; Liquid substance; Massachusetts; Measurement; Measures; Mechanics; Membrane; Methods; Mixed Conductive-Sensorineural Hearing Loss; Modeling; Molds; Motion; Movement; Otologic Surgical Procedures; Outcome; Oval Window; Pathologic; Pathway interactions; Patients; Performance; Play; Preparation; Procedures; Property; Quality of life; Research; Risk; Role; Safety; Sensorineural Hearing Loss; Sensory; Shapes; Side; Slide; Specimen; Stapes; Structure; System; Techniques; Temporal bone structure; Testing; Transducers; Variant; Work; conventional therapy; design; electric impedance; flexibility; implantation; improved; middle ear; middle ear disorder; novel; patient safety; pressure; research study; response; round window; sound; success; transmission process; vibration

PROJECT SUMMARY Conventional treatment for conductive hearing loss normally includes hearing aids or middle ear surgery, which restores movement or continuity of the ossicular chain. However, in cases where conventional surgery is unsuitable or unsuccessful, instead of relying on sound transduction via the normal path involving the ossicular chain and the oval window, round window (RW) stimulation has been attempted with some success. A current issue with RW stimulation is the large variability in efficacy of the device between patients. The effective coupling of the device to the RW membrane has a big influence on the transmission of motion from the device to the inner ear, and may therefore affect the success of an implant. Secondly, difference in the anatomy of inner ear structures may also affect the efficacy of a device by providing paths for acoustic leak along the cochlea. Therefore, understanding the variability and significance of middle ear anatomy (for device-RW coupling interface) and inner ear structures (to further fundamental scientific knowledge on RW stimulation) is essential in the effort to improve current devices. To achieve these goals, we have three main aims. We will comprehensively study the anatomy with cadaveric whole specimens as well as histological temporal bone slide sections in Aim 1. In Aim 2, we will develop and test an effective RW stimulation device that will safely and efficiently couple the device vibration to the inner-ear. This will be tested on cadaveric human temporal bones by measuring the stapes velocity and changes in inner ear pressures in response to the stimulation at the RW. Finally, in Aim 3, we will develop a computational model utilizing the calculated impedance obtained by our experiment measurements, to aid in understanding the mechanism of RW stimulation. This model will account for the impedances both in air conduction stimulation and RW stimulation. Overall, the proposed middle and inner ear research in fresh human cadaveric specimens will provide new and thorough understanding of the RW and develop a detailed impedance model of the human cochlea. The proposed research can lead to a safe and effective RW stimulation device that will improve hearing and quality of life for patients with conductive and mixed hearing loss.

项目概要 传导性听力损失的常规治疗通常包括助听器或中耳手术，这 恢复听骨链的运动或连续性。然而，如果采用传统手术 不适合或不成功，而不是依靠通过涉及听小骨的正常路径进行声音传导 链和椭圆窗、圆窗（RW）刺激的尝试已取得一些成功。电流 RW 刺激的问题是患者之间设备的功效存在很大差异。有效的 设备与 RW 膜的耦合对设备的运动传输有很大影响 内耳，因此可能会影响植入的成功。其次，解剖结构上的差异 内耳结构还可能通过提供沿着耳道的声音泄漏路径来影响设备的功效。 耳蜗。因此，了解中耳解剖结构的变异性和意义（对于设备-RW 耦合接口）和内耳结构（以进一步了解 RW 刺激的基础科学知识） 对于改进现有设备至关重要。为了实现这些目标，我们有三个主要目标。我们将 全面研究尸体整体标本的解剖结构以及颞骨的组织学结构 目标 1 中的幻灯片部分。在目标 2 中，我们将开发并测试一种有效的 RW 刺激装置，该装置将安全地 并将设备振动有效地耦合到内耳。这将在人类尸体颞叶上进行测试 通过测量镫骨速度和内耳压力的变化来响应刺激 RW。最后，在目标 3 中，我们将利用获得的计算阻抗开发一个计算模型 通过我们的实验测量，帮助理解 RW 刺激的机制。该模型将 考虑气导刺激和 RW 刺激中的阻抗。总体而言，建议 对新鲜人类尸体标本的中耳和内耳研究将提供新的、彻底的 了解 RW 并开发人类耳蜗的详细阻抗模型。拟议的 研究可以开发出一种安全有效的 RW 刺激装置，该装置将改善听力和生活质量 传导性听力损失和混合性听力损失的患者。