Sleep and Circadian Contributions to Nighttime Blood Pressure Rhythms (SCN-BP)

睡眠和昼夜节律对夜间血压节律 (SCN-BP) 的影响

• 批准号: 10577473
• 负责人: Stephen J Thomas
• 金额: $ 61.18万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577473
• 关键词: Academic Medical Centers; Activities of Daily Living; Address; Age; Alabama; Ambulatory Blood Pressure Monitoring; Antihypertensive Agents; Behavior Therapy; Behavioral; Biological; Blood Pressure; Blood Pressure Monitors; Body Temperature; California; Cardiovascular Diseases; Cessation of life; Characteristics; Chronotherapy; Circadian Rhythms; Clinical; Clinical Sciences; Data; Detection; Development; Educational workshop; Ethnic Origin; Future; Home Blood Pressure Monitoring; Hour; Human; Hypertension; Intervention; Jet Lag Syndrome; Light; Los Angeles; Low Prevalence; Measurement; Melatonin; Morbidity - disease rate; National Heart, Lung, and Blood Institute; New York; Organ; Participant; Pattern; Persons; Pharmaceutical Preparations; Phase; Phenotype; Play; Population; Population Sciences; Posture; Prevalence; Protocols documentation; Questionnaires; Race; Research; Role; Salivary; Sampling; Site; Sleep; Sleep Fragmentations; Strategic Planning; System; Time; Universities; Wrist; actigraphy; age difference; awake; blood pressure control; blood pressure reduction; cardiovascular disorder risk; circadian; cohort; design; feeding; improved; mortality; participant enrollment; precision medicine; prevent; primary outcome; secondary outcome; sex; shift work; sleep behavior; social; therapy development

Project Summary High asleep systolic blood pressure (SBP) and a non-dipping blood pressure (BP) pattern (a <10% decrease in SBP from being awake to asleep) are very common, each with a prevalence >30%, and both are associated with a 1.5 to 3-fold increased risk for cardiovascular disease (CVD) morbidity and mortality. Circadian and sleep-related factors are two of the most likely contributors to high asleep SBP and non-dipping BP. A better understanding of both circadian and sleep contributions, as well as the alignment between sleep behaviors and chronotype, to asleep BP levels and rhythms will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD. The overall objective of the proposed study is to determine the associations of chronotype and sleep-related factors with mean BP, and BP dipping (Aim 1); the association of alignment between sleep timing and chronotype with mean BP, and BP dipping (Aim 2); and the association of circadian phase and amplitude with BP dipping under constant conditions (Aim 3). The proposed study, titled “Sleep and Circadian Contributions to Nighttime Blood Pressure (SCN-BP)” will achieve Aims 1 and 2 by collecting sleep and circadian data using questionnaires and wrist actigraphy as part of a large, diverse cohort of research participants at 3 sites (the University of Alabama at Birmingham [UAB], Columbia University Medical Center, and Kaiser Permanente Southern California). SCN-BP will then enroll participants who successfully complete Aims 1 and 2 at UAB to complete a 30-hour Constant Routine (CR) Protocol to determine circadian phase and amplitude, as well as BP levels under constant conditions. Findings from the proposed study will provide data that are critical to understand two of the most likely factors that contribute to high asleep BP and non-dipping BP, as well as generate preliminary data to examine the impact of non-sleep factors (e.g., feeding) on asleep BP levels and dipping. The proposed study is unique in that it will combine population science approaches in Aims 1 and 2 with basic/clinical science approaches in Aim 3 in a large, diverse sample sufficiently powered to examine differences by age, sex, race/ethnicity, and antihypertensive medication use. The proposed study will allow for the development of interventions to lower asleep BP, restore BP dipping, and reduce BP-related CVD.

项目概要 高睡眠收缩压 (SBP) 和非下降血压 (BP) 模式（a 从清醒到睡眠时 SBP 降低 <10%）非常常见，每种情况都有一定的患病率 >30%，两者都与心血管疾病风险增加 1.5 至 3 倍相关 (CVD) 发病率和死亡率是最有可能的两个因素。 导致高睡眠收缩压和非下降血压的因素 更好地了解这两种昼夜节律。 和睡眠贡献，以及睡眠行为和睡眠时间型之间的一致性， 睡眠血压水平和节律将有助于制定降低睡眠的干预措施 血压，恢复血压下降，减少血压相关的CVD。 拟议研究的总体目标是确定时间型和 睡眠相关因素与平均血压和血压下降的关系（目标 1）； 睡眠时间和睡眠时间类型与平均血压和血压下降之间的关系（目标 2）； 在恒定条件下昼夜节律相位和幅度与血压下降的关联（目标 3）拟议的研究，题为“睡眠和昼夜节律对夜间血压的影响” (SCN-BP)”将通过问卷调查收集睡眠和昼夜节律数据来实现目标 1 和 2 腕部活动记录仪作为 3 个地点（ 阿拉巴马大学伯明翰分校 [UAB]、哥伦比亚大学医学中心和 Kaiser 南加州永久医疗机构 (Permanente Southern California)）随后将招收成功的参与者。 在 UAB 完成目标 1 和 2，完成 30 小时恒定常规 (CR) 方案 确定昼夜节律相位和幅度，以及恒定条件下的血压水平。 拟议研究的结果将提供对于理解其中两个至关重要的数据 最有可能导致高睡眠血压和非下降血压的因素，以及产生 检查非睡眠因素（例如进食）对睡眠血压水平影响的初步数据 拟议的研究的独特之处在于它将结合人口科学。 目标 1 和 2 中的方法与目标 3 中的基础/临床科学方法在一个大的、多样化的领域中 样本有足够的能力来检查年龄、性别、种族/民族的差异，以及 拟议的研究将有助于开发抗高血压药物。 降低睡眠血压、恢复血压下降并减少血压相关心血管疾病的干预措施。