Amplifying Our Voice: Understanding HIV PrEP Promotional Messaging to CreateAuthentic PrEP Content by Men Who Have Sex with Men in the Deep South

放大我们的声音：了解 HIV PrEP 宣传信息，以创建南方腹地男男性行为者真实的 PrEP 内容

• 批准号: 10560642
• 负责人: Ronnie M Gravett
• 金额: $ 19.1万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10560642
• 关键词: AIDS prevention; Address; Adherence; Affect; Authorization documentation; Award; Awareness; Back; Behavioral Model; Characteristics; Communities; Data; Dedications; Deep South; Development; Development Plans; Disparity; Empathy; Enabling Factors; Epidemic; Ethnic Origin; Evaluation; Failure; Future; Goals; HIV; HIV diagnosis; Health; Health Services; Health behavior; Homophobia; Human immunodeficiency virus test; Image; Institutional Racism; Interview; K-Series Research Career Programs; Medical; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Minority Groups; Newly Diagnosed; Outcome; Patient-Focused Outcomes; Phase; Physicians; Population; Populations at Risk; Predisposing Factor; Prevention strategy; Prophylactic treatment; Provider; Race; Research Personnel; Role; Sampling; Services; Sexual Health; Structure; Surveys; Tablets; Tenofovir; Testing; Text; Training; United States; United States National Institutes of Health; Voice; Work; age stratification; authority; barrier to care; black men who have sex with men; collaborative environment; community engagement; community involvement; crowdsourcing; design; digital; digital intervention; empowerment; emtricitabine; experimental study; health care service utilization; health disparity; homonegativity; human centered design; improved; innovation; male health; member; men; men who have sex with men; model design; multidisciplinary; multilevel analysis; novel strategies; pre-exposure prophylaxis; preference; prevent; prevention service; recruit; sex; sexual minority; skills; social media; social stigma; systemic barrier; therapy design; uptake

1 PROJECT SUMMARY/ABSTRACT: 2 This K23 award will allow Ronnie M. Gravett, MD, to train under multidisciplinary, expert mentorship to become 3 an independent patient-oriented outcomes researcher dedicated to improving the HIV outcomes affecting sexual 4 minority persons in the Deep South. HIV disproportionately affects men who have sex with men (MSM) in the 5 Deep South, a region in the United States with the highest burden of new HIV diagnoses. Pre-exposure 6 prophylaxis (PrEP) effectively prevents HIV acquisition among MSM, but there is a significant lag in PrEP uptake 7 and persistence in the Deep South when compared to other regions of the US. Barriers, such as systemic racism, 8 stigma, and homonegativity, prevent MSM from adequately accessing and using this effective strategy. The high 9 burden of HIV and inadequate PrEP uptake are NIH priorities that need novel strategies to address, such as 10 empowering and effective PrEP promotional strategies to increase PrEP uptake. Yet, there is a critical gap in 11 understanding HIV prevention messaging that is informed by the greater context of the intersecting identities and 12 known barriers to PrEP uptake among MSM in the Deep South. To address this gap, this project will examine 13 preferences for PrEP promotional messaging in order to create authentic and informative PrEP messages 14 through crowdsourcing, an innovative strategy wherein a group solves a common problem and the solution is 15 given back to the group. Integrating constructs of Andersen’s Behavioral Model of healthcare utilization and 16 community engagement into a human-centered design model will serve as the framework for this project. This 17 project will address the gap through the following specific aims: 1) explore preferences for PrEP messaging 18 content among MSM in the Deep South through qualitative interviews, 2) using a discrete choice experiment 19 (DCE), define the preferred attributes for PrEP messaging content to inform the format for the crowdsourcing 20 open call, and 3) compare MSM preferences for crowdsourced services to standard services to inform a digital 21 intervention designed to increase PrEP uptake among MSM in the Deep South. Crowdsourced content created 22 during this project will be compared to health authority content to show that community-derived content is 23 preferred by MSM. The training plan will combine formal coursework, intensive seminars, and expert mentorship 24 focused on the following topics: 1) quantitative, qualitative, and mixed methodologies, 2) design and conduct of 25 discrete choice experiments, and 3) crowdsourcing to create authentic PrEP promotional messaging. This K23 26 award will support the development of affirming, effective content to improve HIV prevention strategies among 27 MSM while also providing mentorship from renowned content and methodological experts, structured, 28 multidisciplinary training in a collaborative environment, and the avenue for Dr. Gravett to develop into an 29 independent physician investigator and leading expert in HIV prevention among sexual minorities in the Deep 30 South.

1 项目概要/摘要： 2 该 K23 奖项将使医学博士 Ronnie M. Gravett 在多学科专家指导下接受培训，成为 3 一位独立的以患者为导向的结果研究人员，致力于改善影响性行为的艾滋病毒结果 4 南方腹地的少数族裔人群中，艾滋病毒对男男性行为者 (MSM) 的影响尤为严重。 5 南部腹地，美国新发艾滋病毒暴露前诊断负担最高的地区。 6 预防 (PrEP) 可有效防止 MSM 中感染 HIV，但 PrEP 的吸收存在显着滞后 7 与美国其他地区相比，南方腹地的持续存在障碍，例如系统性种族主义， 8 耻辱和同性消极性阻碍了 MSM 充分获取和使用这一有效策略。 9 HIV 负担和 PrEP 摄入不足是 NIH 的优先事项，需要新的策略来解决，例如 10 种增强 PrEP 普及率的有效推广策略 然而，在这方面仍存在重大差距。 11 了解艾滋病毒预防信息，这些信息是通过交叉身份的更大背景来传达的 南方腹地的 MSM 采取 PrEP 的 12 个已知障碍 为了解决这一差距，本项目将进行研究。 PrEP 宣传信息的 13 种偏好，以创建真实且信息丰富的 PrEP 信息 14 通过众包，创新策略为团队提供了解决共同问题的方法，解决方案是 15 反馈给小组的安徒生医疗保健利用行为模型的整合结构。 16 社区参与以人为本的设计模型将作为该项目的框架。 17 项目将通过以下具体目标解决这一差距：1) 探索 PrEP 信息传递的偏好 18 内容通过定性访谈在南方腹地的 MSM 中进行，2) 使用离散选择实验 19 (DCE)，定义 PrEP 消息传递内容的首选属性，以告知众包的格式 20 公开征集，以及 3) 将 MSM 对众包服务的偏好与标准服务进行比较，以告知数字 21 旨在提高南方腹地 MSM 的 PrEP 接受率的干预措施 创建了众包内容。 22 在该项目期间，将与卫生当局的内容进行比较，以表明社区衍生的内容 23 MSM 首选 培训计划将结合正式课程、强化研讨会和专家指导。 24 重点关注以下主题：1) 定量、定性和混合方法，2) 设计和实施 25 个离散选择实验，以及 3) 众包创建真实的 PrEP 促销信息。 26 奖项将支持开发肯定的、有效的内容，以改善艾滋病毒预防策略 27 MSM 同时还提供知名内容和方法专家的指导，结构化、 28 协作环境中的多学科培训，以及 Gravett 博士发展成为一名 29 位独立医师调查员和深层性少数群体艾滋病毒预防领域的领先专家 南30号。