Hormone Assay and Analytical Core

激素测定和分析核心

• 批准号: 9049477
• 负责人: Alan D Cherrington
• 金额: $ 22.43万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-04-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9049477
• 关键词: Address; Amino Acids; Area; Biological Assay; Contract Services; Controlled Environment; Cost Analysis; Data; Diabetes Mellitus; Equipment; Fee-for-Service Plans; Funding; Gluconeogenesis; Glucose; Grant; Hormones; Human Resources; Individual; Institution; Laboratories; Lipids; Liquid substance; Measurement; Metabolic; Methods; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Nucleotides; Oxidative Stress; Physiology; Postdoctoral Fellow; Procedures; Process; Productivity; Protocols documentation; Publications; Quality Control; Reagent; Reporting; Research; Research Assistant; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Running; Sampling; Services; Standardization; Students; System; Time; Tissue Sample; Training and Education; Wages; Work; cost; cost effective; cost efficient; equipment acquisition; experience; high throughput screening; improved; in vivo; innovation; instrumentation; interest; meetings; member; metabolic phenotype; method development; operation; programs

The Hormone Assay and Analytical Services Core (HAASC) provides assistance to investigators in the measurement of hormones, amino acids ( concentration and specific activity), glucose enrichment, lipids, nucleotides, and markers of oxidative stress in biologic fluids and tissue samples. The core provides space, equipment and personnel that performs sample analysis and method development. Investigators pay a fee for service that covers the cost of regents, supplies, a percentage of personnel salary and pro-rated service contracts. Over the last grant cycle this core has dramatically evolved. With support from the institution the core has purchased equipment that will lower overall cost and decrease turnaround time for our standard high throughput assays and are continuing to offer cost effective new hormone assays to our investigators. The core has developed NMR assays to assess the enrichment of glucose (C2/C5), which is a marker of gluconeogenesis. We have expanded the scope of our services as the needs of VDRTC members change. The core assayed over 30,000 samples in the past year for 32 Vanderbilt investigators and 7 non-Vanderbilt investigators. Over the past grant cycle it provided data to support over 150 publications. The HAASC is jointly supported by the VDRTC and the NIDDK-funded Mouse Metabolic Phenotyping Center. This cooperative arrangement allows the core to offer a wide range of services in a non-overlapping, cost efficient manner. The core is part of the Vanderbilt Core Ordering & Reporting Enterprise Systemtm, which provides an efficient billing system and oversight and governance for the core. The Hormone Assay and Analytical Services Core, in operation for more than 30 years, continues to provide essential services that support the research of DRTC-affiliated investigators in the next funding cycle.

激素分析和分析服务核心（HAASC）在测量激素，氨基酸（浓度和特定活性），葡萄糖富集，脂质，核苷酸，核苷酸和氧化应激标志的测量中为研究者提供了援助。核心提供了执行样本分析和方法开发的空间，设备和人员。调查人员支付涵盖摄政，供应费用，人事工资的百分比和评价服务合同的服务费用。在最后一个赠款周期中，这个核心已经大幅发展。在该机构的支持下，核心购买了设备，该设备将降低整体成本并减少我们标准高通量测定法的周转时间，并继续向调查人员提供成本效益的新激素分析。核心已经开发了NMR分析，以评估葡萄糖的富集（C2/C5），该葡萄糖是糖异生的标志。随着VDRTC成员的需求变化，我们扩大了服务的范围。在过去的一年中，核心分析了32名范德比尔特调查人员和7位非人物比尔特调查人员的样本。在过去的赠款周期中，它提供了数据以支持150多个出版物。 HAASC由VDRTC和NIDDK资助的小鼠代谢表型中心共同支持。这种合作的安排使核心可以以非重叠的，具有成本效益的方式提供广泛的服务。核心是Vanderbilt核心订购和报告企业SystemTM的一部分，该企业SystemTM为核心提供了有效的计费系统，监督和治理。激素分析和分析服务核心在运营30多年的运作中继续提供基本服务，以支持下一个资金周期中与DRTC相关研究人员的研究。