HORMONE ASSAY % ANALYTICA SERVICES CORE

激素%20测定%20%%20分析%20服务%20核心

• 批准号: 7284643
• 负责人: Alan D Cherrington
• 金额: $ 26.83万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7284643
• 关键词: Advisory Committees; Automation; Back; Biological Assay; Blood; Blood Plasma Volume; Canis familiaris; Catecholamines; Charge; Contract Services; Diabetes Mellitus; Endocrine; Endocrinology; Equipment; Family suidae; Fees; Funding; Glucagon; Grant; Growth; Hormones; Human; Human Resources; Hydrocortisone; Insulin; Leptin; Liquid substance; Maintenance; Measurement; Measures; Metabolic; Methods; Mus; Numbers; Operative Surgical Procedures; Pancreatic Polypeptide; Peptides; Physiology; Program Evaluation; Rate; Reagent; Research; Research Personnel; Rodent; Sampling; Services; Somatotropin; Surveys; Technology; Testing; Validation; assay development; cost; design; glucagon-like peptide 1; improved; method development; quality assurance

The Hormone Assay Core assists investigators in the measurement of hormones in biologic fluids as related to diabetes, endocrine and metabolic research. The core provides space, equipment, and personnel for sample analysis and method development. User charge backs support the cost of reagents, supplies and pro-rated service contracts. The analysis available include 1) insulin, 2) free insulin, 3) glucagon, 4) cortisol, 5) catecholamines, 6) growth hormone, 7) c-peptides (human, canine, porcine), 8) pancreatic polypeptides, 9) leptin, 10) ratcorticosterone, and 11) GLP-1 (active). Several of these assays are available in "micro" methods for the analysis of hormone levels in very small volumes of plasma or blood. Furthermore, some assays are designed to measure hormones in a particular species. The core has the potential to develop new tests and technologies to expand the scope of its current testing. An annual survey is conducted to determine the needs of users for new assays. Over the past grant period, there has been an increased demand for at least half of the services offered and a constant demand for the remainder. The core will be expanded to meet an expected growth in demand that is anticipated as a result of funding of a Murine Metabolic and Physiology Center. An advisory Committees will deal with issues of coordination between the DRTC and MMPC, as well as user fees and new service implementation.

激素测定核心协助研究人员测量生物液体中的相关激素 糖尿病、内分泌和代谢研究。核心提供空间、设备和人员 样品分析和方法开发。用户退款支持试剂、耗材和 按比例分配的服务合同。可用的分析包括 1) 胰岛素，2) 游离胰岛素，3) 胰高血糖素，4) 皮质醇、5) 儿茶酚胺、6) 生长激素、7) C 肽（人、犬、猪）、8) 胰腺 多肽，9) 瘦素，10) 大鼠皮质酮，和 11) GLP-1（活性）。其中有几种检测方法可供使用 用于分析极少量血浆或血液中激素水平的“微”方法。 此外，一些测定被设计用于测量特定物种的激素。核心有 开发新测试和技术以扩大当前测试范围的潜力。年度调查 进行以确定用户对新测定的需求。在过去的资助期内，有 对所提供的至少一半服务的需求增加，并且对其余服务的需求保持不变。核心 将扩大以满足预期的需求增长，该需求预计是由于资助小鼠而产生的 代谢和生理学中心。咨询委员会将处理协调问题 DRTC 和 MMPC，以及用户费用和新服务实施。