Gold nanoparticles as vascular disruptig agents in radiation therapy of NSCLC

金纳米粒子作为血管破坏剂在非小细胞肺癌放射治疗中的应用

基本信息

批准号：
9026582
负责人：
Ross I. Berbeco
金额：
$ 21.63万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-03-03 至 2018-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9026582
关键词：
Area Benign Biodistribution Blood Circulation Blood Vessels Cancer Model Cell Death Clinic Clinical Clinical Trials Data Development Diffusion Dose Electrons Endothelial Cells Endothelium External Beam Radiation Therapy Funding Generations Goals Gold Health Image Injection of therapeutic agent Innovative Therapy Kidney Kinetics Lead Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of lung Measures Medicine Molecular Target Neoplasms in Vascular Tissue Non-Small-Cell Lung Carcinoma Optics Organ Patient risk Patients Penetration Pharmaceutical Preparations Photons Radiation Radiation Oncology Radiation therapy Research Research Infrastructure Rewards Risk Solid Neoplasm Structure Techniques Testing Therapeutic Time Tissues Toxic effect Travel United States National Institutes of Health base cancer cell cancer therapy clinical practice clinically significant fluorescence imaging image guided radiation therapy improved in vivo intravenous injection irradiation minimal risk mouse model nano nanoparticle neovasculature novel pre-clinical spectral energy therapeutic target translational study tumor tumor progression uptake

项目摘要

DESCRIPTION (provided by applicant): Recent developments in anti-angiogenic and vascular-disrupting therapies have shown the great potential of tumor vasculature as a therapeutic target for cancer medicine. We have an original idea for using targeted gold nanoparticles (GNP) as vascular disruptive agents (VDA) in conjunction with clinical megavoltage photon beams. Unlike competing proposals, we recognize that gold nanoparticles tend to accumulate in, and can even be targeted for, tumor blood vessels and that these structures may be more important for anti-cancer therapy than clonogenic cell death alone. Due to the short distance traveled by x-ray induced photoelectrons, the endothelial cells of the tumor will receive a sizable boost in dose, even for clinical megavoltage (MV) photon irradiation. Our preliminary results include: development, characterization and testing of a novel 4th generation nano-platform; theoretical and experimental evidence of dose enhancement in a MV clinical radiation therapy beam-line; and imaging studies of preferential tumor uptake. The proposed study will determine the optimal time window for radiation therapy after GNP administration and measure the therapy benefit in a preclinical lung cancer model. Our innovative therapy concept is highly compatible with current clinical practice and could offer a substantial clinical benefit with minimal patient risk.

描述（由申请人证明）：抗ngiogenic和血管毛线毛线毛线盘的抗乳房乳头脉冲脉管系统的最新发展是癌症医学的明星。 vda）在近期的竞争性建议中，甚至可以针对肿瘤血管，而对于抗癌而言，与单独的剂量增强相比，肿瘤血管可能更重要。用于临床的光子辐射（MV）。在临床前肺癌模型中，治疗和衡量治疗有益。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Key clinical beam parameters for nanoparticle-mediated radiation dose amplification.

DOI：
10.1038/srep34040
发表时间：
2016-09-23
期刊：
Scientific reports
影响因子：
4.6
作者：
Detappe A;Kunjachan S;Drané P;Kotb S;Myronakis M;Biancur DE;Ireland T;Wagar M;Lux F;Tillement O;Berbeco R
通讯作者：
Berbeco R

Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance-Computed Tomography Image Guided Radiation Therapy.

DOI：
10.1021/acs.nanolett.6b05055
发表时间：
2017-03-08
期刊：
Nano letters
影响因子：
10.8
作者：
Detappe A;Thomas E;Tibbitt MW;Kunjachan S;Zavidij O;Parnandi N;Reznichenko E;Lux F;Tillement O;Berbeco R
通讯作者：
Berbeco R