Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy

用于 MR 引导放射治疗的铋钆纳米颗粒的转化

基本信息

批准号：
10359706
负责人：
Ross I. Berbeco
金额：
$ 59.5万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10359706
关键词：
A549 Aorta Biodistribution Biological Bismuth Blood Vessels Brain Cancer Patient Chemistry Clinic Clinical Collaborations Contrast Media Dana-Farber Cancer Institute Data Disease Dose Dose-Limiting Drug Kinetics Environment Esophagus Exhibits Formulation Gadolinium Goals Histopathology Image Lead Letters Lung Lung Neoplasms Magnetic Resonance Imaging Malignant neoplasm of lung Methods Modeling Non-Small-Cell Lung Carcinoma Normal tissue morphology Operative Surgical Procedures Organ Paper Patient risk Patients Phase I Clinical Trials Phase II Clinical Trials Process Property Radiation Radiation Oncology Radiation Physics Radiation therapy Research Personnel Rodent Safety Schedule Solid Neoplasm Structure Technology Testing Therapeutic Therapy Evaluation Toxic effect Translating Translations Tumor Tissue Work base biomaterial compatibility cancer cell cancer therapy clinical practice clinical translation clinically relevant contrast enhanced contrast imaging design effective therapy improved in vivo industry partner innovation irradiation lung lesion nano nanoparticle nonhuman primate novel particle patient population phase I trial pre-clinical prototype scale up success translational model trend tumor tumor growth uptake

项目摘要

Project Summary Recent preclinical and clinical results have demonstrated the safety and efficacy of nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an emerging paradigm that would benefit from specific contrast agents. This Academic- Industrial Partnership will leverage these current trends by designing, developing and rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting data consists of extensive physical and biological characterization of gadolinium and bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and therapy results in multiple tumor models. In this project, we will develop and optimize a direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform extensive toxicity and therapy evaluation in a translational model under clinical delivery schedules and conditions. Our innovative and highly translatable imaging and therapy concept is compatible with current and emerging clinical practice and could offer a substantial clinical benefit with minimal patient risk.

项目概要最近的临床前和临床结果证明了其安全性和有效性纳米粒子放大放射治疗。与此同时，MR 引导放射治疗是一种受益于特定造影剂的新兴范例。这个学术- 工业合作伙伴关系将通过设计、开发和利用这些当前趋势严格测试用于 MR 引导放射治疗的新型纳米颗粒。我们的配套数据包括钆的广泛物理和生物特征以及铋钆基纳米颗粒，包括体内生物分布、成像和治疗产生多种肿瘤模型。在这个项目中，我们将开发并优化一个铋钆纳米颗粒的直接高产率合成方法及其性能临床交付转化模型中的广泛毒性和治疗评估时间表和条件。我们创新且高度可转化的成像和治疗概念与当前和新兴的临床实践兼容，可以提供显着的临床效益和最小的患者风险。