Neural mechanisms of eye gaze perception in schizophrenia

精神分裂症眼睛注视感知的神经机制

• 批准号: 9178692
• 负责人: Ivy Fei Tso
• 金额: $ 16.62万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178692
• 关键词: Accounting; Activation Analysis; Affect; Amygdaloid structure; Anterior; Area; Attention; Behavior; Behavioral; Biological Neural Networks; Biometry; Brain; Brain region; Clinical; Code; Cognition; Cognitive; Cognitive deficits; Communication; Complement; Cues; Data; Detection; Development Plans; Disease; Educational Intervention; Educational workshop; Electrophysiology (science); Elements; Emotional; Eye; Face; Functional Magnetic Resonance Imaging; Funding; Fusiform gyrus; Future; Goals; Health; Impaired cognition; Impairment; Individual; Insula of Reil; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Light; Medial; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Neurocognitive; Parietal; Participant; Perception; Performance; Prefrontal Cortex; Process; Psychologist; Psychophysics; Publishing; Recruitment Activity; Research; Research Domain Criteria; Research Personnel; Schizophrenia; Social Functioning; Social Perception; Societies; Source; Superior temporal gyrus; System; Techniques; Therapeutic; Training; Training Activity; Training Programs; Translating; Translational Research; Visual; Visual Cortex; Visual Perception; Work; abstracting; attentional control; autism spectrum disorder; base; career; career development; causal model; cognitive function; cognitive process; cognitive task; cognitive training; design; disability; effective therapy; emotion regulation; experience; functional disability; functional outcomes; gaze; human centered computing; improved; innovation; intervention program; meetings; mental state; network dysfunction; network models; neuroimaging; neuromechanism; prevent; psychologic; relating to nervous system; response; responsible research conduct; severe mental illness; skills; social; social cognition; theories; visual process; visual processing

Project Summary/Abstract Functional impairment of schizophrenia (SZ) poses a tremendous burden on society and shows limited response to pharmacologic treatments. Previous work by the Candidate (Dr. Ivy Tso) and others suggest that early visual processing and eye gaze perception are two cognitive processes with important functional implications, but unanswered questions about the source of these deficits and dynamic interactions between these processes limit the usefulness of this knowledge to design effective treatment. This K23 Career Development Award proposal aims to advance research in this area through two broad goals: 1) To delineate a brain network model of gaze perception deficits in SZ using functional MRI and dynamic causal modeling (DCM); and 2) To provide a promising candidate with training in advanced fMRI network techniques and translational research skills to accelerate the translation of research findings to innovative cognitive interventions. The proposed project will study 40 SZ participants and 40 health controls, and probe gaze perception and visual integration using two psychophysics paradigms during fMRI. Behavioral performance and brain activation will be compared between SZ and HC, and the effect of SZ on directional connectivity between key brain regions recruited in gaze perception will be identified using DCM. The specific research aims are: 1) To characterize the brain activation profile of altered visual integration and gaze perception in SZ and its relationship to functional outcome; and 2) To characterize the brain network profile of gaze processing in SZ and identify abnormal effective connectivities underlying gaze perception deficits. This K23 research will help define a treatment target for a future intervention study. Dr. Tso is a clinical psychologist with demonstrated experience in publishing and obtaining funding in behavioral and electrophysiological research in eye gaze perception in SZ. She is committed to translating her research findings to innovative cognitive interventions. She will work closely with a team of experts who collectively provide mentorship in a multitude of training domains: Primary Mentor Stephan Taylor (fMRI, responsible conduct of research), Co- mentor Vaibhav Diwadkar (network analyses and DCM), and Consultants Scott Peltier (fMRI), Timothy Johnson (Bayesian biostatistics), Michael Green (social cognition and functional assessment), Sophia Vinogradov (cognitive training and intervention research), and Emily Mower Provost (human-centered computing). Training will be complemented and augmented by formal coursework, specialized short courses, workshops, scientific meetings, and other training activities as described in the Career Development Plan. Dr. Tso’s short-term career goal is to acquire a new skillset in fMRI network modeling and become an independent translational neuroimaging researcher. Her long-term career goal is to develop a comprehensive research and intervention program to effectively treat and prevent severe and persistent mental illnesses. The proposed K23 Award is a crucial step in fulfilling these career goals.

项目摘要/摘要 精神分裂症（SZ）的功能障碍对社会构成了巨大的伯恩，显示有限 对药物治疗的反应。候选人的先前工作（Ivy TSO博士）和其他人表明 早期的视觉处理和眼目光感知是两个具有重要功能的认知过程 含义，但是关于这些缺陷来源和动态互动之间的尚未解决的问题 这些过程限制了这种知识对设计有效治疗的有用性。这个K23职业 开发奖提案旨在通过两个广泛的目标来推进这一领域的研究：1） 凝视感知的大脑网络模型使用功能性MRI和动态因果建模定义SZ （DCM）; 2）为候选人提供高级fMRI网络技术的培训和 转化研究技能，以加速研究结果对创新认知的翻译 干预措施。拟议的项目将研究40名SZ参与者和40个健康控制，并探测目光 fMRI期间使用两个心理物理学范式的感知和视觉整合。行为表现 SZ和HC之间将比较大脑的激活，以及SZ对方向连通性的影响 在凝视感知中募集的关键大脑区域之间将使用DCM确定。具体研究 目的是：1）表征改变视觉整合和凝视感知的大脑激活曲线 SZ及其与功能结果的关系； 2）表征凝视的大脑网络轮廓 在SZ中进行处理，并确定视力感知基础的有效连接性异常。这个K23 研究将有助于定义未来干预研究的治疗目标。 TSO博士是临床心理学家 具有出版和获得行为和电生理学资金的经验 SZ的眼睛注视感知研究。她致力于将自己的研究发现转化为创新 认知干预措施。她将与一个专家团队紧密合作，他们共同提供 多种训练领域：主要导师斯蒂芬·泰勒（FMRI，负责任的研究），共同 导师Vaibhav Diwadkar（网络分析和DCM）和顾问Scott Peltier（fMRI），蒂莫西 约翰逊（贝叶斯生物统计学），迈克尔·格林（社会认知和功能评估），索菲亚 Vinogradov（认知培训和干预研究）和Emily Mower教务长（以人为本 计算）。培训将由正式课程，专业的短课程，专门的课程完成和增强 职业发展计划中描述的讲习班，科学会议和其他培训活动。博士 TSO的短期职业目标是获得fMRI网络建模的新技能，并成为独立 翻译神经影像学研究人员。她的长期职业目标是制定一项全面的研究和 干预计划有效治疗和预防严重和持续性精神疾病。提议 K23奖是实现这些职业目标的关键一步。