Analytic Core C

分析核心C

• 批准号: 9074567
• 负责人: Enrique Cadenas
• 金额: $ 36.87万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9074567
• 关键词: Alleles; Alzheimer' s Disease; Alzheimer' s disease risk; Animals; Apolipoprotein E; Archives; Bioenergetics; Bioinformatics; Biological; Biological Markers; Blood specimen; Brain; Clinical; Clinical Data; Complementary DNA; Custom; Data Analyses; Databases; Development; Disease; Early identification; Estradiol; Gene Expression Profile; Gene Expression Profiling; Gene Targeting; Generic Drugs; Genes; Genetic; Genotype; Goals; Human; Inflammatory; Intervention; Lead; Link; Literature; Longevity; Menopause; Metabolic; Methods; Mission; Molecular Profiling; Pathology; Pathway Analysis; Pathway interactions; Perimenopause; Phenotype; Play; Population; Postmenopause; Primary Cell Cultures; Principal Component Analysis; Process; Progesterone; Protein Isoforms; Proteins; RNA; Regimen; Regulation; Research; Research Infrastructure; Resources; Risk; Risk Factors; Rodent; Role; Sampling; Steroids; System; Systems Biology; Technology; Tissue Sample; Translating; Woman; aging brain; apolipoprotein E-4; base; brain metabolism; brain tissue; cognitive function; data integration; data management; density; endophenotype; functional group; lipid metabolism; neuroimaging; prevent; programs; steroid hormone; tool

PROJECT SUMMARY-ANALYTIC CORE C The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to discover biological transformations in brain that occur during the perimenopausal transition that lead to endophenotypes predictive of risk for Alzheimer's disease (AD). Our goals are to identify the mechanisms by which these transformations occur and to translate these discoveries into strategies to prevent conversion to an at-Alzheimer's-risk phenotype. To achieve our Perimenopausal Program Project mission, we have developed a set of integrated program-wide specific aims that span mechanistic discovery to clinical neuroimaging in ApoE genotyped perimenopausal and postmenopausal women to a global population through the ENIGMA network of neuroimages, clinical data and ApoE genetics. The mission of Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and distribution, as well as analytic support across the Perimenopausal Program Project. The mission of Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and distribution, as well as analytic support across the Program Project. To achieve this mission, the Analytic Core will provide two levels of support. The first level of support entails standardized steroid hormone regimens and sample management. The second level of support entails sample analysis and data interpretation on four major studies: LC-MS/MS steroid analysis, ApoE genotyping, custom array gene expression analysis, and bioinformatic gene functional analysis. Analytic Core was an instrumental and essential resource for the previous Progesterone Program Project and the currently ongoing Perimenopause Program Project. Through the infrastructure and analytic methods it has developed, Analytic Core will continue to play a crucial role in achieving the renewed Perimenopausal Program Project's mission and aims.

项目摘要 - 分析核心C 我们围绝经期在大脑衰老和阿尔茨海默氏病计划项目（P3）中的使命是 发现在围绝经内过渡期间发生的大脑中的生物转化 预测阿尔茨海默氏病风险（AD）的内表型。我们的目标是确定机制 通过这些转化并将这些发现转化为防止这些发现的策略 转换为At-Alzheimer的风险表型。为了实现我们的绝经计划项目任务， 我们已经开发了一组整合程序范围的特定目的，这些目标跨越机械发现 APOE基因分型围绝经和绝经后妇女的临床神经影像学到全球 通过神经图像，临床数据和APOE遗传学的谜网络的人群。任务 分析核心是提供标准化的类固醇激素方案，样本归档，加工和 分布以及跨绝经计划项目的分析支持。任务 分析核心是提供标准化的类固醇激素方案，样本归档，加工和 分发以及整个计划项目的分析支持。为了实现这一任务，分析 核心将提供两个级别的支持。第一级支持需要标准化的类固醇激素 方案和样本管理。第二级支持需要样本分析和数据 对四项主要研究的解释：LC-MS/MS类固醇分析，APOE基因分型，自定义阵列基因 表达分析和生物信息学基因功能分析。分析核心是一种工具， 先前的孕酮计划和当前正在进行的基本资源 围门计划项目。通过它开发的基础架构和分析方法 分析核心将继续在实现新的围绝经计划中发挥关键作用 项目的使命和目标。