IGF::OT::IGF LTRC CLINICAL CENTER - TASK ORDER 001; SUBJECT CHARACTERIZATION AND TISSUE PROCUREMENT

IGF::OT::IGF LTRC 临床中心 - 任务单 001；

• 批准号: 9304634
• 负责人: KEVIN FLAHERTY
• 金额: $ 29.11万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9304634
• 关键词: Appearance; Blood specimen; Categories; Chronic Obstructive Airway Disease; Clinical; Clinical Data; Collection; Connective Tissue Diseases; Data; Disease; Excision; Future; Goals; Hamman-Rich syndrome; Image; Individual; Interstitial Lung Diseases; Interstitial Pneumonia; Lead; Lung; Lung diseases; Malignant neoplasm of lung; National Heart, Lung, and Blood Institute; Nodule; Operative Surgical Procedures; Participant; Pathogenesis; Physiological; Research; Research Personnel; Respiratory physiology; Structure of parenchyma of lung; Tissue Procurements; Tissue Sample; Tissues; lung metastatic; meetings; novel

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was originally established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from participants with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. LTRC III’s primary focus will shift to the collection of lung tissue and clinical data from control participants who require lung resection. These control participants will primarily come from individuals with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. Control participants may also come from individuals with suspected lung cancer but with normal lung function. For either category, non-neoplastic tissue will be collected remotely from a nodule or mass. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases. It is the ultimate goal of this study that information derived from the LTRC will lead to novel interventional treatments for all disease categories under study.

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was originally established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiological studies, and radiographic studies from participants with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic间质性肺炎（IIP）和间质性肺炎与接受医学指示的肺切除的连接组织疾病相关。 LTRC III的主要重点将转移到需要肺部切除的对照参与者的肺组织和临床数据中的收集。这些对照参与者将主要来自怀疑的间质性肺疾病（ILD）的人，他们在病理检查后表现出没有这种疾病。对照参与者也可能来自怀疑肺癌但肺功能正常的人。对于这两种类别，非肿瘤组织将从结节或质量中远程收集。所有组织和血液标本以及临床数据都将库存并存储，以分配给未来的研究人员，这些研究人员批准了研究建议，并正在研究优先的肺部疾病的发病机理。这项研究的最终目标是，从LTRC获得的信息将导致所有正在研究的疾病类别进行新的介入治疗。