Mechanisms of Eukaryotic Gene Regulation

真核基因调控机制

• 批准号: 9070234
• 负责人: James T. Kadonaga
• 金额: $ 38.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9070234
• 关键词: Animals; Biological Phenomena; Chromatin; Drosophila genus; Future; Gene Expression; Gene Expression Regulation; Genes; Genetic Transcription; Histones; Human; Laboratories; Lead; Malignant Neoplasms; Molecular; RNA Polymerase II; Regulation; Research; Role; Structure; Transcription Process; base; biological research; frontier; human disease; insight; public health relevance

 DESCRIPTION (provided by applicant): The long-term objective of the research in the Kadonaga laboratory is to understand the mechanisms of regulation of RNA polymerase II transcription in bilateria (bilaterally-symmetric animals). Why is it important to study gene expression? A thorough understanding of gene expression is essential because the basis of a diverse range of biological phenomena (including many human diseases such as some cancers) can be traced to the proper or improper expression of a gene or set of genes. Thus, new insights into the mechanisms of gene expression will have a broad impact upon a wide range of biological research. The Kadonaga lab has sought to explore new and often underappreciated frontiers in chromatin and transcription. In this manner, they have been able to make a number of unique contributions to the understanding of gene regulation. In the future, they plan to study the diversity of mechanisms of the basal transcription process and the role of chromatin, particularly non-nucleosomal histone-containing structures, in the regulation of gene expression. These topics will be studied both individually as well as in concert to gain the best possible understanding of how genes are regulated in bilateria such as Drosophila and humans.

 描述（由应用提供）：Kadonaga实验室研究的长期目标是了解双侧（双侧对称动物）中RNA聚合酶II转录的调节机制。为什么研究基因表达很重要？对基因表达的彻底理解是必不可少的，因为潜水员的生物学现象范围（包括许多人类疾病，例如某些癌症）可以追溯到基因或一组基因的适当或不当表达。这是对基因表达机制的新见解将对广泛的生物学研究产生广泛的影响。卡多纳加实验室（Kadonaga Lab）感觉到探索染色质和转录中的新的且通常不足的边界。通过这种方式，他们能够为理解基因调节做出许多独特的贡献。将来，他们计划研究基本转录过程机制的多样性以及染色质的作用，尤其是含非核小组组蛋白的结构，在基因表达的调节中。这些主题将进行单独研究，也将在协同协调一致地进行研究，以最大程度地了解果蝇和人类等双侧的基因如何调节。