MHAS Cognitive Aging Ancillary Study

MHAS 认知老化辅助研究

• 批准号: 9133253
• 负责人: Rebeca Wong
• 金额: $ 32.25万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9133253
• 关键词: Adult; Aging; Aging-Related Process; Ancillary Study; Archives; Area; Belief; Biological Markers; Childhood; Cognition; Cognitive aging; Comparative Study; Country; Data; Data Analyses; Data Collection; Data Sources; Databases; Dementia; Developed Countries; Developing Countries; Elderly; Family; Family Study; Fostering; Funding; Genetic Crossing Over; Goals; Health; Impaired cognition; Individual; Institution; International; Interview; Interviewer; Knowledge; Latin America; Latin American; Lead; Life; Link; Longitudinal Studies; Measures; Methodology; Methods; Mexican; Mexico; Parents; Prevalence; Procedures; Protocols documentation; Proxy; Public Health; Research; Research Personnel; Rest; Retirement; Risk Factors; Sampling; Sampling Studies; Societies; Structure; Surveys; Survivors; Time; Training; United States; United States National Institutes of Health; Visit; Walking; Work; aged; aging population; cognitive testing; design; experience; field study; knowledge base; migration; mortality; outreach; performance tests; population based; program dissemination; usability

 DESCRIPTION (provided by applicant): The Mexican Health and Aging Study (MHAS) is a national longitudinal study of individuals aged 50 and older in Mexico, with three waves of data covering from 2001 to 2012, and wave-4 planned for 2015. Since its inception, the MHAS has been highly comparable to the Health and Retirement Study (HRS) in the United States, using similar protocols and survey contents. The overall goal of the proposed project is to assess the prevalence and risk factors of dementia and other cognitive impairments in Mexico with a harmonized approach, working with similar studies globally that use national samples and a population-based approach. The specific aims are: 1) Contribute to harmonization in the global study of dementia by launching an ancillary study of the national sample of older adults in Mexico, the MHAS. 2) Estimate the national prevalence of dementia and cognitive impairment in Mexico, harmonized with other countries, by using comparable data analysis strategies and methods. 3) Maximize the utilization of the MHAS data for cross-national dementia studies, by archiving, documenting, and disseminating the ancillary study databases and its resulting constructed variables. The ancillary study will include approximately 3,000 subjects, a sub-sample of the full MHAS wave-4 sample. The databases for the ancillary interview will include results from in-depth cognitive assessments and biomarkers, anthropometric measures, and performance tests. The harmonization goal will be achieved by collaborating with a `coordination project' conducted by researchers of the Health and Retirement Study (HRS) in the United States and through them, with the family of similar studies in the rest of the world. We will harmonize as much as possible, from the fieldwork training materials to the data cleaning, treatment of non-response, and methods used to cross-walk from the ancillary study to the full MHAS sample to estimate national prevalence of dementia and other cognitive impairments. The proposed ancillary study in Mexico will further enhance the analytical power of the parent study MHAS, enabling rigorous cross-national examination of the risk factors and consequences of dementia, an under- studied condition in developing countries that are aging rapidly.

 描述（由适用提供）：墨西哥健康与衰老研究（MHAS）是一项全国性的纵向研究，对墨西哥50岁及50岁以上的个体，在2001年至2012年之间进行了三波数据范围，并且计划于2015年进行。自从其启动以来，MHA与健康和退休研究（HRS）相似，并使用了与美国的健康相似，并使用了与Nites nestess相似的研究。拟议项目的总体目的是通过统一的方法评估墨西哥痴呆症和其他认知障碍的患病率和危险因素，并与全球类似的研究一起使用国家样本和基于人群的方法。具体目的是：1）通过对墨西哥墨西哥的全国老年人样本进行辅助研究，在全球痴呆症研究中有助于协调。 2）通过使用可比的数据分析策略和方法，估计墨西哥痴呆症和认知障碍的全国患病率。 3）通过归档，文档和传播辅助研究数据库及其由此产生的构造变量来最大化MHA数据用于跨国痴呆研究。辅助研究将包括大约3,000名受试者，这是完整的MHAS Wave-4样本的子样本。辅助访谈的数据库将包括深入认知评估和生物标志物，人体测量测量和性能测试的结果。协调目标将通过与美国卫生与退休研究（HRS）研究人员和通过它们合作，与世界其他地区的类似研究家族合作。从现场工作培训材料到数据清洁，无响应的处理以及用于跨越辅助研究的方法到完整的MHAS样本，我们将尽可能地协调，以估计痴呆症和其他认知障碍的全国流行。墨西哥提出的辅助研究将进一步增强父母研究的分析能力，从而对痴呆症的危险因素和后果进行严格的跨国检查，这是发展中国家迅速衰老的疾病。