In-Line 32-Channel Connector for High-Density Implantable Medical Device

适用于高密度植入式医疗设备的直插式 32 通道连接器

• 批准号: 8634210
• 负责人: Douglas B. Shire
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8634210
• 关键词: Address; Affect; Amputation; Amputees; Animal Experiments; Animal Model; Animals; Ankle; Award; Biomedical Engineering; Chronic; Clinical; Clinical Research; Clinical Trials; Contracts; Custom; Data; Development; Devices; Documentation; Electric Stimulation; Electrodes; Equipment Malfunction; Esthesia; Extravasation; FDA approved; FPS-FES Oncogene; Family Felidae; Functional disorder; Future; Gait; Generations; Hip region structure; Implant; In Vitro; Intervention; Knee; Laboratories; Life; Limb structure; Location; Mechanics; Medical Device; Methods; Mission; Modeling; Monitor; Motor; Multiple Sclerosis; Muscle; Nanotechnology; Nerve; Neurological rehabilitation; Operative Surgical Procedures; Paraplegia; Partner in relationship; Patient Care; Patients; Peripheral; Peripheral Nerves; Peripheral Nervous System Diseases; Phantom Limb; Physical activity; Population; Process; Prostheses and Implants; Prosthesis; Publishing; Rehabilitation therapy; Research; Research Personnel; Running; Site; Source; Spinal cord injury; Stroke; Structure; System; Techniques; Technology; Testing; Tissues; Titania; Titanium; Universities; Upper Extremity; Vendor; Veterans; Visit; Walking; Work; animal facility; base; biomaterial compatibility; combat; density; design; devices for disabled persons; implantable device; implantation; improved; in vitro testing; neural prosthesis; neuroprosthesis; next generation; post stroke; programs; public health relevance; relating to nervous system; research clinical testing; seal; sensory feedback

DESCRIPTION (provided by applicant): The aim of this proposal is to develop the next generation of miniature, high- density multi-channel connectors suitable for chronic implantation in a patient's body as part of systems that are used, for example, to treat disorders of the peripheral nervous system. Maladies that could be treated in this way are problems with walking, such as after a stroke, and restoring natural sensations in a phantom limb after amputation. In this study, we will use custom-microfabricated connector bodies to facilitate interconnections within and among long-lasting neural interfaces. Custom packaging and assembly methods for the miniature connectors will also be developed. The tasks to be accomplished under this proposal include the fabrication of new HD connectors for mating with pre-existing micro-neurostimulator designs. We will also evaluate the long- term biocompatibility and bio-stability of these connectors through both in vitro experiments and animal surgical trials. The data collected will facilitate future application to the FDA to do follow-on clinical studies of medical devices incorporating high density connector technology. The relationship between the proposed effort and the patient care mission of the VA is that these improvements are expected to increase the interchangeability of components of implantable neurostimulation systems for rehabilitation that have high channel counts. This will improve new devices under development such as implantable walking aids and devices for restoring natural sensation in amputated limbs.

描述（由申请人提供）： 该提案的目的是开发下一代微型，高密度的多通道连接器，适合于患者体内的慢性植入，作为用于治疗周围神经系统疾病的系统的一部分。可以以这种方式治疗的疾病是步行问题（例如中风后）的问题，并在截肢后恢复了幻影肢体中的自然感觉。 在这项研究中，我们将使用定制的微制连接器体来促进持久神经界面内部和之间的互连。还将开发用于微型连接器的自定义包装和组装方法。该建议下要完成的任务包括制造新的高清连接器，用于与先前存在的微神经刺激器设计交配。我们还将通过体外实验和动物手术试验评估这些连接器的长期生物相容性和生物稳定性。收集的数据将促进将来对FDA的应用，以对融合高密度连接器技术的医疗设备进行跟进临床研究。 拟议的努力与VA的患者护理任务之间的关系是，这些改进有望提高可植入的神经刺激系统组件的互换性，用于康复，具有高通道计数。这将改善正在开发的新设备，例如可植入的步行辅助工具和用于恢复截肢肢体自然感觉的设备。