High-Density Hermetic Packaging for Next-Generation Neural Prostheses

用于下一代神经假体的高密度密封包装

• 批准号: 8668984
• 负责人: Douglas B. Shire
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8668984
• 关键词: Activities of Daily Living; Affect; Age; Age related macular degeneration; Aging; American; Animal Model; Area; Belief; Blindness; Boston; Brain; Bypass; Ceramics; Chronic; Cochlear Implants; Collaborations; Commit; Complex; Custom; Degenerative Disorder; Development; Devices; Electric Stimulation; Electrodes; Eye; Funding; Future; Generations; Grant; Hearing; Hearing Impaired Persons; Human; Image; Implant; In Vitro; Inherited; Institutes; Knowledge; Laboratories; Lead; Learning; Legal Blindness; Macular degeneration; Massachusetts; Medicine; Methods; Microfabrication; Miniature Swine; Mission; Movement; Neurostimulation procedures of spinal cord tissue; Ocular Prosthesis; Operative Surgical Procedures; Optic Nerve; Partner in relationship; Patient Care; Patients; Photoreceptors; Population; Prosthesis; Psychophysics; Publishing; Rehabilitation therapy; Research; Retina; Retinal; Retinal Diseases; Retinitis Pigmentosa; Structure; Sum; Technology; Testing; Time; Tissues; Titania; Titanium; Translating; Vendor; Vertebrate Photoreceptors; Veterans; Vision; Visual; Visual Acuity; Visual Fields; Visual impairment; Wireless Technology; Work; abstracting; biomaterial compatibility; blind; clinically relevant; cost; density; design; disability; falls; implantation; improved; innovation; medical schools; miniaturize; neural prosthesis; neural stimulation; next generation; patient population; pre-clinical; relating to nervous system; research study; restoration; retinal neuron; retinal prosthesis; social; success; technology development; visual information

DESCRIPTION (provided by applicant): Project Summary/Abstract The aim of this proposal is to develop a new generation of miniaturized implantable micro-stimulators suitable for chronic implantation in a patient's eye to treat degenerative diseases of the retina. In this study, we will use polyimide electrode array structures coated with inorganic materials to provide a long-lasting implant-tissue interface. Custom packaging and assembly methods for the prostheses will also be developed. The tasks to be accomplished under this proposal include the microfabrication of multi-layered electrode array structures in polyimide for mating with our micro-neurostimulator designs. We will also evaluate the biocompatibility and biostability of these structures, which will be done in part at the CIVR through both in vitro soak-testing experiments and through survival surgeries in Yucatan mini- pig animal models with active and passive devices. Together with our vendors, we will fabricate new generations of high-density ceramic feedthroughs and incorporate these into state-of-the- art 200-channel hermetic titanium packages for our retinal microstimulators that will lead to clinically relevant visual prosthetics. The relationship between the proposed effort and the ongoing patient care mission of the VA is that these improvements are expected to open up new rehabilitative possibilities through more specific, targeted neural stimulation than has previously been possible- especially for the restoration of truly useful vision to blind patients, but also in other areas of medicine such as deep brain or spinal cord stimulation. In sum, it is our hope that the blind population we serve will ultimately benefit from the improved visual acuity that will arise from our ability to create complex, highly biostable retinal neurostimulators; additionally, the channel capacity and efficacy of future wireless implantable prostheses of all types is expected to be improved.

描述（由申请人提供）： 项目摘要/摘要该提案的目的是开发新一代的微型植入式微型刺激剂，适合于患者眼中的慢性植入，以治疗视网膜的退行性疾病。在这项研究中，我们将使用涂有无机材料的聚酰亚胺电极阵列结构来提供持久的植入物界面。也将开发针对假体的定制包装和装配方法。在此提案中要完成的任务包括在聚酰亚胺中的多层电极阵列结构的微结构，以与我们的微神经刺激器设计交配。我们还将评估这些结构的生物相容性和生物稳定性，这些结构将通过体外浸泡测试实验以及通过具有主动和被动设备的尤卡坦微型猪动物模型的生存手术在CIVR中进行。我们将与我们的供应商一起制造新一代的高密度陶瓷进料，并将其纳入最先进的200频道密封钛钛包装中，以便我们的视网膜微刺激剂，这将导致临床上相关的视觉假体。拟议的努力与VA的持续患者护理任务之间的关系是，预计这些改进将通过更具体的，有针对性的神经刺激来开放新的康复可能性，这比以前的可能性相比，尤其是对于恢复对盲人的真正有用的愿景的可能性，但在其他医学领域，例如深脑或脊髓刺激。 总而言之，我们希望我们所服务的盲人人口最终将受益于提高的视力，这将源于我们创建复杂，高度可生物biostal的视网膜神经刺激剂的能力。此外，预计所有类型的未来无线植入体假体的通道容量和功效将得到改善。