Arterial stiffness in mother/infant dyads: Life course approach to prevent cardiovascular disease

母婴二人的动脉僵硬度：预防心血管疾病的生命全程方法

基本信息

批准号：
10581158
负责人：
Kim A Boggess
金额：
$ 17.76万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10581158
关键词：
Abdomen Address Adipose tissue Aging Alabama Biological Blood Vessels Body Composition Body fat Body mass index Cardiovascular Diseases Cohort Studies Complement Data Data Collection Development Disease Management Dual-Energy X-Ray Absorptiometry Enrollment Fatty acid glycerol esters Female General Population Goals Health Hour Infant Knowledge Learning Life Cycle Stages Maternal Health Measures Medical Medicine Mentors Mentorship Minority Women Mothers North Carolina Not Hispanic or Latino Obesity Overweight Pattern Perinatal Perinatal Care Physiologic pulse Positioning Attribute Postpartum Period Postpartum Women Pre-Eclampsia Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy Rate Pregnant Women Prevalence Proxy Race Reporting Research Research Personnel Research Project Grants Risk Risk Factors Scanning Site Technology Time Ultrasonography United States Universities Visceral Visceral fat Visit Woman abdominal fat arterial stiffness black women cardiometabolism cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health career clinical practice cohort design diet and exercise disorder risk ethnic diversity ethnic minority experience gestational weight gain health care availability high body mass index high risk population improved innovation lifestyle intervention modifiable risk multidisciplinary parent grant pregnancy hypertension pregnant prenatal prevent racial disparity racial diversity racial minority response risk stratification social vascular inflammation

项目摘要

ABSTRACT Greater than 45% of women in the United States experience excessive gestational weight gain (GWG) leading to increased cardiovascular disease (CVD) risk during pregnancy, postpartum and beyond (≥10 years). Excess fat accumulation and specific fat distribution patterns, such as abdominal visceral fat, accelerate vascular aging in the general population. However, the composition of GWG is scarcely reported. Therefore, a knowledge gap exists in understanding whether the vascular aging response is associated with changes in body composition and fat distribution during pregnancy and postpartum. This proposal supplements the Mother and Infant Determinants of vascular Aging Study (MIDAS; R01HL157075). The MIDAS study will enroll 840 racially and ethnically diverse healthy and medically complicated mother/infant dyads between 34-40 weeks gestation. At 34-40 weeks gestation, within 48 hours of delivery, and at 6 and 12 months postpartum, the MIDAS study will assess vascular aging and CVD risk by measuring pulse wave velocity (PWV), and examine relationships among biologic, personal, social, and ecological disease risk factors with PWV. The objective of this proposal is to elucidate how body composition (Aim 1) and fat distribution (Aim 2) changes during and following pregnancy impact postpartum CVD risk. Although obesity, defined by body mass index, is a proposed modifiable risk factor, body composition (i.e., %fat) and fat distribution (i.e., visceral adipose tissue) were not a focus of the parent grant. Therefore, this proposal will complement the existing MIDAS study by leading the data collection and in-depth analysis of gestational and postpartum body composition. The study specific aims are: 1) determine the association between the trajectory of %fat from 34-40 weeks gestation to 12 months postpartum and PWV at 12 months postpartum in 840 racially and ethnically diverse pregnant women, and 2) determine the association between the change in fat distribution from 6 to 12 months postpartum with PWV at 12 months postpartum in a subset of women (n=280). We will also explore whether race moderates the proposed associations in Aims 1 and 2; racial and ethnic minority women have a greater prevalence of obesity and are at a greater risk for pregnancy complications and CVD compared with non-Hispanic white women. This time sensitive supplement leverages access to a large, diverse cohort of pregnant and postpartum women and a multi-disciplinary team of mentors with expertise in CVD risk and maternal health. As a result, we are well positioned to complete the proposed aims. Additionally, this supplement will enable an early career investigator to: 1) gain experience conducting a well-defined research project evaluating CVD risk in pregnant women, 2) develop her grantsmanship and, 3) expand her research network and learn from a successful mentorship team. This supplement will be an integral component to the MIDAS study by focusing on adiposity- related risk to maternal cardiovascular health and it will provide an early career investigator with support to advance her career trajectory and establish an independent, fundable research line.

抽象的超过 45% 的美国女性经历过妊娠体重增加 (GWG) 导致怀孕期间、产后及以后（≥10年）心血管疾病（CVD）风险增加。脂肪堆积和特定的脂肪分布模式，例如腹部内脏脂肪，会加速血管老化然而，GWG 的组成却很少被报道，因此存在知识差距。存在于了解血管老化反应是否与身体成分的变化有关该建议补充了母亲和婴儿在怀孕期间和产后的脂肪分布。血管老化的决定因素研究（MIDAS；R01HL157075） MIDAS 研究将按种族和年龄招募 840 名受试者。妊娠 34-40 周之间的种族多样化、健康且医学上复杂的母婴组合。妊娠 34-40 周、产后 48 小时内以及产后 6 个月和 12 个月时，MIDAS 研究将通过测量脉搏波速度 (PWV) 评估血管老化和 CVD 风险，并检查关系生物、个人、社会和生态疾病风险因素与 PWV 的关系本提案的目标。是为了阐明身体成分（目标 1）和脂肪分布（目标 2）在训练期间和之后如何变化尽管肥胖（由体重指数定义）是被提议的，但怀孕会影响产后心血管疾病风险。可改变的危险因素、身体成分（即脂肪百分比）和脂肪分布（即内脏脂肪组织）不是因此，该提案将通过领导现有的 MIDAS 研究来补充。该研究的具体目标是收集妊娠期和产后身体成分的数据并进行深入分析。是：1) 确定从妊娠 34-40 周到 12 个月的脂肪百分比轨迹之间的关联 840 名不同种族和民族的孕妇的产后和产后 12 个月的 PWV，以及 2) 确定产后 6 至 12 个月的脂肪分布变化与 PWV 之间的关联我们还将探讨种族是否会调节女性产后 12 个月的情况（n=280）。目标 1 和 2 中拟议的协会；少数种族和族裔妇女的肥胖患病率较高；与非西班牙裔白人女性相比，她们患妊娠并发症和心血管疾病的风险更大。这种对时间敏感的补充剂可以接触到大量不同的孕妇和产后妇女以及具有 CVD 风险和孕产妇健康专业知识的多学科导师团队。此外，该补充材料将有助于实现早期职业生涯。研究者：1) 获得开展明确的研究项目的经验，评估孕妇的 CVD 风险女性，2) 发展她的资助才能，3) 扩大她的研究网络并向成功人士学习该补充品将成为 MIDAS 研究的一个组成部分，重点关注肥胖问题。与孕产妇心血管健康相关的风险，它将为早期职业研究者提供支持她的职业轨迹并建立了一个独立的、可资助的研究线。