OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:

其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3：

• 批准号: 9201177
• 负责人: MARSHA DUNN
• 金额: $ 18.61万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9201177
• 关键词: Address; Age; Agriculture; Award; B-Lymphocytes; Biological; Biological Markers; Blood; Businesses; Carcinogenesis Mechanism; Cessation of life; Chronic Lymphocytic Leukemia; Cohort Studies; Collection; Colorectal; Computer Systems; Contractor; Contracts; County; Data; Data Files; Databases; Enrollment; Etiology; Funding; Future; General Population; Health; Home environment; Incidence; Institutes; Interview; Iowa; Licensing; Link; Lung; Lymphocytosis; Malignant Neoplasms; Molecular Epidemiology; Monoclonal gammopathy of uncertain significance; Multiple Myeloma; National Health and Nutrition Examination Survey; Newsletter; North Carolina; Occupational Exposure; Ovarian; Participant; Pesticides; Phase; Prevalence; Prevalence Study; Prostate; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; Protocols documentation; Questionnaires; Records; Recruitment Activity; Research; Research Personnel; Resources; Retrieval; Sampling; Secure; Self-Administered; Specific qualifier value; Specimen; Spouses; Staging; Study Subject; Technology; Telephone Interviews; Universities; Update; Urine; Work; cohort; farmer; field study; follow-up; indexing; interest; leukemia; lifestyle factors; meetings; member; mortality; neoplasm registry; operation; phase 1 study; phase 2 study; phase 3 study; phase 4 study; population based; research study; technology development; web site

The Agricultural Health Study (AHS) cohort consists of approximately 52,000 private pesticide applicators (primarily farmers) and 32,000 spouses of private applicators from Iowa and North Carolina, as well as approximately 5,000 commercial pesticide applicators from Iowa. The pesticide applicators were recruited between 1993-1997 (during Phase I of the AHS) when they obtained or renewed their license to apply restricted use pesticides; spouses were recruited largely by questionnaires brought home by the pesticide applicator (81%). In addition to the extensive information on lifetime use of pesticides, demographic and other lifestyle factors were collected from all participants at enrollment using self-administered questionnaires (during Phase I of the AHS). Two follow-up telephone interviews have been conducted since enrollment. The first follow-up interview was conducted from 1999 to 2003 (during Phase II of AHS), and the second follow-up interview was conducted from 2005-2009 (during Phase III of the AHS). Cancer incidence has been ascertained by annual linkage to the cancer registries in each state and mortality through linkage to the National Death Index since the inception of the study field work in 1993. The AHS began field work for Phase I of the study with three contracts in 1993. One contract was for a coordinating center (SRA Technology) which was primarily responsible for overall coordination of the study, developing questionnaires, and providing a secure computer system to store the vast amount of questionnaire and other research data coming from the field stations in Iowa and North Carolina. The other two contracts were for a field station in Iowa (University of Iowa) and a second field station in North Carolina (Battelle Memorial Institute). Field Stations were primarily responsible for managing the distribution and retrieval of self-administered questionnaires to eligible study subjects. The coordinating center contract was awarded, via a full and open competition, to SRA Technologies for Phase II of the study and to Westat Inc. for Phase III of the study; Westat assumed the coordinating center contract during Phase II when SRA Technologies went out of business. The field station contracts were awarded again, via a full and open competition, to the University of Iowa in Iowa and Battelle Memorial Institute in North Carolina for Phases II and III of the study. In the Phase IV contract, the contractor will be responsible for overall coordination and day-to-day management of the study, maintaining and updating a secure data base containing all study research and administrative records, provide liaison with appropriate state and federal offices necessary to conduct this research, appropriately communicate research findings to the cohort through a website and annual newsletter, and to collect specified biospecimens from selected study subjects. In Phase IV of the AHS, one contractor will perform all study related activities as there will be no cohort-wide interview conducted as part of this contract. The coordinating center will continue to be responsible for day-to-day study operations, managing and maintaining study data files, and coordinating National Advisory Panel meetings. In addition, the coordinating center will now assume responsibility for maintaining and securing the personal identifying information for cohort members; conducting annual linkages to the state cancer registries, state and federal mortality files, IRS address data bases; and facilitating add-on studies. New responsibilities under this contract will be the conduct of the Biomarker Study (BEEA: protocol attached in appendix) which will involve the collection of blood and urine samples from a subset of the cohort.

农业健康研究（AHS）队列由来自爱荷华州和北卡罗来纳州的大约52,000名私人农药施用者（主要是农民）和32,000名私人申请者以及来自爱荷华州的大约5,000名商业农药涂药者。在1993年至1997年（在AHS的第一阶段）之间招募了农药施用者，当时他们获得或续签了施用限制使用农药的许可；配偶主要由问卷调查招募 农药涂抹器（81％）。除了有关终生使用农药的广泛信息外，使用自我管理的问卷（在AHS的第一阶段）收集了所有参与者的人口统计学和其他生活方式因素。自入学以来，已经进行了两次后续电话采访。从1999年到2003年（在AHS的第二阶段）进行了首次随访访谈，并于2005年至2009年（在AHS第三阶段）进行了第二次随访访谈。自1993年研究现场工作以来，通过与每个州的癌症注册处的年度联系，通过与国家死亡指数的联系来确定癌症的发病率。 AHS于1993年通过三项合同开始了研究第一阶段的现场工作。一项合同是协调中心（SRA Technology）的合同，该合同主要负责该研究的整体协调，开发问卷以及提供安全的计算机系统，以存储大量的问卷和来自Iowa和North Carolina的实地站的大量调查数据和其他研究数据。另外两项合同是在爱荷华州（爱荷华大学）的一个现场站和北卡罗来纳州的第二场现场站（巴特尔纪念研究所）。现场站主要负责管理对合格研究对象的自我管理问卷的分布和检索。通过全面而开放的竞争，授予了该研究第二阶段的SRA Technologies和Westat Inc.的协调中心合同；韦斯特（Westat）在第二阶段SRA Technologies倒闭时假设了中心合同。现场车站合同再次通过全面开放的竞争授予爱荷华州的爱荷华大学和北卡罗来纳州的巴特尔纪念研究所，以获得该研究的II和III阶段。 在IV阶段合同中，承包商将负责研究研究的整体协调和日常管理，维护和更新包含所有研究研究和行政记录的安全数据库，为进行该研究所必需的适当州和联邦办公室，并适当地通过网站和年度的新闻社和年度的生物学研究将研究发现与该网站和年度研究的研究。在AHS的第四阶段中，一位承包商将执行所有与研究相关的活动，因为本合同的一部分将不进行范围内的范围访谈。协调中心将继续负责日常学习操作，管理和维护研究数据文件以及协调国家咨询小组会议。此外，协调中心现在将承担维护和确保同类成员的个人身份信息的责任； IRS与州癌症注册机构，州和联邦死亡率文件进行年度联系，以解决数据库；并促进附加研究。本合同下的新职责将是生物标志物研究（附录中附加的BEEA：协议）的行为，该研究将涉及从同类子集的子集收集血液和尿液样本。