Core D - Developmental Neuroimaging Core

核心 D - 发育神经影像核心

• 批准号: 9055068
• 负责人: STEVEN E. PETERSEN
• 金额: $ 22.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9055068
• 关键词: Address; Area; Behavioral; Biological Models; Brain; Child; Clinical; Clinical Research; Communities; Complex; Consultations; Data; Data Analyses; Data Linkages; Development; Developmental Disabilities; Diffusion Magnetic Resonance Imaging; Environment; Functional Magnetic Resonance Imaging; Funding; Genes; Genomics; Goals; Human; Image; Image Analysis; Imaging technology; Infant; Informatics; Intellectual functioning disability; International; Intervention; Investigation; Maps; Measurement; Mental Retardation and Developmental Disabilities Research Centers; Methods; Modality; Morphology; Patients; Perfusion; Phenotype; Population; Preparation; Procedures; Process; Protocols documentation; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rest; Role; Sample Size; Sampling; Scanning; Science; Services; Specific qualifier value; Spectrum Analysis; Staging; Structure; Subjects Selections; Technology; Training; United States National Institutes of Health; Universities; Washington; animal imaging; base; brain behavior; cohort; computerized data processing; cost; data acquisition; design; experience; flexibility; functional genomics; imaging modality; innovation; medical schools; neuroimaging; phenomics; premature; rapid growth; relating to nervous system; success; tool

Developmental Neuroimaging Core Project Summary The goals of the Developmental Neuroimaging Core (DNC) are: to provide a flexible concierge approach to facilitating investigation, from consultation and assistance with study design, to full acquisition and interpretation of human imaging data, to training investigative teams to progressive levels of mastery that will allow them to continue and extend their own IDD research agendas. The DNC will provide state-of-the art neuroimaging services to maximize the quality and impact of IDD research by Center investigators, to optimize the application of imaging as a translational tool for innovation in prediction and intervention in developmental disabilities, and to provide a range of consultative and analytic services that will help new and early stage investigators to incorporate imaging research into their research efforts. The DNC is designed to provide capacity to ascertain neural signatures of developmental disability as a critical facet of the comprehensive characterization of patients and pathogenic mechanisms. Moreover, as rapid advances in imaging technology occur, the DNC will continue to make the latest innovations in neuroimaging accessible to the large and growing investigator community at WUSTL studying IDD. This Core advances IDD research through focused expertise in neuroimaging technology: mock scanning; specialized approaches to data acquisition in un- sedated infants and children with IDD; data analyses predicated upon established brain-behavior relationships in developing children; complete data analyses for early through to experienced investigators; an informatics platform with serial measurement and mapping of developmental trajectories. The Specific Aims are: 1) To provide high-quality comprehensive consultation for study design, including sample selection, subject preparation, technological methods for addressing specific scientific questions, statistical power considerations relevant to sample size and composition, data analytic approaches, brain-behavioral, brain-gene, and brain- environment data linkage, the interpretation of acquired neuroimaging data, and, via the Informatics Unit, its archival storage with other key study variables; 2) To conduct highly cost-efficient data acquisition for IDDRC investigators collecting neuroimaging data in IDD research efforts. This assistance will specify acquisition parameters for each study, implement appropriate subject preparation protocols (e.g. un-sedated infants), optimize image quality for the intended target structures and circuits, and provide all necessary technical support for conducting the scanning procedures, titrated to the need-for-assistance of each respective investigator; 3) To provide data processing and analytic services that optimize the hypothesis-driven analysis, exploration, as well as accurate interpretation of neuroimaging data in IDD research at WUSTL, recognizing that analysis of imaging data—and its integration with genomic, phenomic, and environmental data, can be complex and highly dependent upon the particular imaging modality employed.

发育神经影像学核心项目摘要 发育神经影像核心（DNC）的目标是：提供一种灵活的礼宾方法 促进调查，从研究设计的咨询和协助到全面收购和 对人类成像数据的解释，以训练调查团队进行逐步的精通水平 让他们继续并扩展自己的IDD研究议程。 DNC将提供最先进的 神经影像学服务以最大程度地提高中心研究人员IDD研究的质量和影响，以优化 成像作为预测和干预中创新的转化工具的应用 残疾，并提供一系列协商和分析服务，以帮助新的和早期 调查人员将成像研究纳入他们的研究工作。 DNC旨在提供 确定发育残疾的神经签名的能力，是综合的关键方面 患者的表征和致病机制。此外，随着成像技术的快速发展 发生，DNC将继续为大型和 Wustl研究IDD的研究员社区不断发展。该核心通过重点进行IDD研究 神经影像技术的专业知识：模拟扫描；专门的数据获取方法 患有IDD的婴儿和儿童；数据分析对已建立的脑行为关系进行了预测 在成长的孩子中；对经验丰富的调查人员进行填写的数据分析；信息 具有串行测量和发展轨迹映射的平台。具体目的是：1） 为研究设计提供高质量的综合咨询，包括样本选择，主题 准备，解决特定科学问题的技术方法，统计能力考虑因素 与样本量和组成，数据分析方法，大脑行为，脑部和脑有关 环境数据链接，获得的神经影像数据的解释，以及通过信息学单元 与其他关键研究变量的档案存储； 2）为IDDRC进行高成本效率的数据获取 在IDD研究工作中收集神经影像数据的研究人员。此帮助将指定收购 每项研究的参数，实施适当的主题准备方案（例如未介绍的婴儿）， 优化预期目标结构和电路的图像质量，并提供所有必要的技术 支持执行扫描程序，并滴定为每个亲戚的需求辅助 研究者; 3）提供数据处理和分析服务来优化假设驱动的 分析，探索以及对Wustl IDD研究中神经影像数据的准确解释， 认识到对成像数据的分析及其与基因组，现象和环境的整合 数据可以很复杂，并且高度依赖于特定的成像方式员工。