Genome Technologies Coordinating Center

基因组技术协调中心

• 批准号: 10571905
• 负责人: Mark D ADAMS
• 金额: $ 149.81万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-20 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571905
• 关键词: Acceleration; Access to Information; Adoption; Area; Award; Awareness; Benchmarking; Biological; Biology; Collaborations; Communication; Communities; Community Outreach; Complex; Data; Development; Disease; Education; Education and Outreach; Educational Materials; Evaluation; Experimental Models; Exposure to; Foundations; Funding; Funding Opportunities; Genetic Research; Genome; Genomic medicine; Genomics; Goals; Grant; Human Genetics; Human Genome; Informatics; Information Resources; Institution; Intellectual Property; Laboratories; Malignant Neoplasms; Mammalian Genetics; Medicine; National Human Genome Research Institute; Nucleic Acids; Nucleic acid sequencing; Office of Administrative Management; Outcome; Peer Review; Performance; Persons; Phenotype; Pilot Projects; Process; Qualifying; Recording of previous events; Research; Research Personnel; Resources; Role; Science; Scientist; Standardization; Structure; Technology; Technology Transfer; The Jackson Laboratory; Underrepresented Populations; Underserved Population; centralized portal; comparative; education resources; experience; genome analysis; genome-wide; human model; improved; innovation; innovative technologies; insight; instrumentation; interest; meetings; mouse genome; new technology; novel strategies; outreach; programs; success; symposium; technology development; trait; virtual; web site; working group

PROJECT SUMMARY The Genome Technology portfolio at NHGRI encompasses a substantial diversity of scientific approaches and objectives, from instrumentation development to high-throughput application of technologies to characterizing the genomic basis for phenotypic traits. These research efforts have produced significant insight into biology and disease, and yet there are many opportunities to accelerate innovation, development, and early dissemination of genomic technologies. The goal of the Genome Technology Coordinating Center (GTCC) is to maximize these opportunities by liaising grantees and NHGRI Program Staff, managing research funds, and developing educational resources to support and tout the excellence of the Genome Technology program. We propose the following aims to meet these goals: 1) Facilitate collaborations across the Genome Technology Program and promote standards that aid in achieving Program goals. We will host and support Annual meetings for the Genome Technology and CEGS programs. We will also develop Working Groups among grantees to promote collaboration-building and the development of metrics and standards for genomic technologies. We will use these Working Groups to identify gaps in the field that will provide the foundation for solicitation of Opportunity Funds. 2) Establish and manage an Opportunity Funds program to support initial development of promising new technologies and ideas. These Opportunity Funds will be distributed as pilot projects (early stage or proof-of- principle studies) and development projects (comparatively advanced studies with supportive preliminary data) in years 2-4. Peer review will be conducted by an External Review Panel of experts in genomic technology. 3) Implement community outreach activities to encourage awareness of Genome Technology Program successes and facilitate access by the scientific community. We will develop and manage an Education and Outreach Working Group composed of grantees and educational experts to identify and prioritize areas of development for educational materials, and host and advertise a website to distribute those materials. A targeted effort will be made to expose underrepresented and underserved populations in science to the advances and importance of the Genome Technology Program. Informational resources related to technology transfer and intellectual property will be developed for grantees. The Jackson Laboratory (JAX) is uniquely qualified to serve as the GTCC for the Genome Technology Program. The Laboratory has over ninety years of history in supporting mammalian genetics research including through the provision of widely used information resources (e.g. Mouse Genome Informatics) and educational programs including the Annual Short Course on Experimental Models of Human Cancer (29 years), and the McKusick Short Course on Human and Mammalian Genetics and Genomics (nearly 60 years). The Jackson Laboratory for Genomic Medicine was established in 2012 to apply the Lab’s expertise in genomics and technology development toward improvements in genome-based medicine.

项目概要 NHGRI 的基因组技术组合涵盖了多种科学方法和 目标，从仪器开发到技术的高通量应用再到表征 这些研究工作对生物学和表型性状的基因组基础产生了重要的见解。 疾病，但仍有许多机会加速创新、发展和早期传播 基因组技术协调中心 (GTCC) 的目标是最大限度地利用这些技术。 通过联络受资助者和 NHGRI 项目工作人员、管理研究资金以及开发 我们建议提供教育资源来支持和宣扬基因组技术计划的卓越性。 以下目标旨在实现这些目标： 1) 促进基因组技术计划之间的合作 我们将主办和支持年度会议，以促进有助于实现计划目标的标准。 我们还将在受资助者之间建立工作组来促进基因组技术和 CEGS 项目的发展。 我们将利用这些来建立合作并制定基因组技术的指标和标准。 工作组确定该领域的差距，为募集机会基金奠定基础。 2) 建立和管理机会基金计划，以支持有前景的新产品的初步开发 这些机会基金将作为试点项目（早期或验证项目）进行分配。 研究）和开发项目（具有支持性初步数据的比较先进的研究） 第 2-4 年，同行评审将由基因组技术专家组成的外部评审小组进行。 实施社区外展活动，以鼓励人们了解基因组技术计划的成功 我们将开发和管理教育和外展活动。 由受资助者和教育专家组成的工作组，负责确定发展领域并确定优先顺序 教育材料，并主办和宣传一个网站来分发这些材料。 旨在让科学界代表性不足和服务不足的人群了解科学的进步和重要性 基因组技术计划与技术转让和知识产权相关的信息资源。 杰克逊实验室 (JAX) 是唯一有资格作为受资助者开发的财产。 GTCC 基因组技术计划实验室在支持基因组技术计划方面拥有九十多年的历史。 哺乳动物遗传学研究，包括通过提供广泛使用的信息资源（例如小鼠 基因组信息学）和教育计划，包括年度实验模型短期课程 人类癌症（29 岁），以及 McKusick 人类和哺乳动物遗传学和基因组学短期课程 （近60年）杰克逊基因组医学实验室成立于2012年，以应用实验室的成果。 基因组学和技术开发方面的专业知识，以改进基于基因组的医学。