Pacific Center for Emerging Infectious Diseases Research

太平洋新发传染病研究中心

• 批准号: 10576202
• 负责人: VIVEK Ramchandra NERURKAR
• 金额: $ 96.76万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-14 至 2023-07-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10576202
• 关键词: Affect; Animals; Arabia; Area; Asia; Avian Influenza; Award; Basic Science; Bioinformatics; Biological; Biological Sciences; Biomedical Research; Businesses; Cellular Immunology; Center for Translational Science Activities; Centers of Research Excellence; China; Clinical Research; Collaborations; Communicable Diseases; Communities; Custom; Development; Diagnostic tests; Ebola; Economics; Emerging Communicable Diseases; Ensure; Epidemic; Epigenetic Process; Extramural Activities; Faculty; Fostering; Foundations; Funding; Future Generations; Genetic; Geography; Goals; Grant; Growth; Guinea; Hawaii; Health; Human; Infectious Diseases Research; Infrastructure; Institution; International; Investments; Liberia; Mentors; Microbiology; Middle East Respiratory Syndrome; Mission; Modeling; Molecular Immunology; Monitor; Movement; National Institute of General Medical Sciences; Native Hawaiian; Nutritional; Pacific Islander; Pakistan; Parasites; Pathogenicity; Persons; Phase; Poliomyelitis; Population Growth; Positioning Attribute; Prevention; Preventive Medicine; Principal Investigator; Productivity; Public Health; Rapid diagnostics; Research; Research Personnel; Research Priority; Resource Sharing; Resources; Science; Scientist; Services; Sierra Leone; Speed; Stream; System; Therapeutic; Training; Training Support; Training and Education; Translational Research; Triad Acrylic Resin; Tropical Medicine; United States National Institutes of Health; Universities; Urbanization; Vaccines; base; biobehavior; clinical infrastructure; data sharing; disease diagnosis; ethnic disadvantage; ethnic minority; graduate student; higher education; improved; marginalized community; microbial; multidisciplinary; next generation; novel vaccines; operation; programs; public health relevance; recruit; research and development; social; therapeutically effective; underserved community

 DESCRIPTION (provided by applicant): Established in 2003, the Pacific Center for Emerging Infectious Diseases Research, a translational science center of excellence supported by funding from the Centers of Biomedical Research Excellence (COBRE) component of the Institutional Development Award (IDeA) program, seeks to develop and deploy rapid diagnostics, improved therapeutics and affordable vaccines for new, emerging and re-emerging infectious diseases that disproportionately affect underserved communities in the Asia-Pacific region. The COBRE Center also seeks to increase the diversity of the biomedical research workforce by training and mentoring native Hawaiians and other underrepresented Pacific Islanders. Thus, the Center's mission is thoroughly consistent with that of the National Institute of General Medical Sciences, which is to support basic research that lays the foundation for advances in disease diagnosis, treatment and prevention, and to increase the diversity of the research workforce by supporting the training of the next generation of scientists (http://www.nigms.nih.gov/About/Pages/default.aspx). The principal objective of the Phase III COBRE for emerging infectious diseases is to enhance the conditions that accelerate the pace of scientific discovery, heighten research productivity and increase competitiveness for extramural funding. The objective will be achieved by (1) enhancing the growth and sustainability of the COBRE cores in biocontainment, bioinformatics, and molecular and cellular immunology, which are grounded in the triad of customized and collaborative service, research and development, and education and training; and (2) developing and implementing a COBRE Small Grants Program, without borders, that fosters collaborations and partnerships, promotes data and resource sharing, and provides additional opportunities for mentoring and specialized training across IDeA-funded centers in research aimed at improving human health. COBRE funding during Phases I and II has transformed the landscape for mentoring and training future generations of investigators and has provided state-of-the-art core resources for multi-disciplinary collaborative research on epidemic infectious diseases. At the institutional level, COBRE funding has spurred significant commitments to recruit and retain a new cadre of productive faculty, and such efforts will continue into Phase III. High-level upper-administrative institutional commitments will ensure the sustainability of the Center and its cores beyond the Phase III COBRE period.

 描述（由申请人提供）：太平洋新发传染病研究中心成立于 2003 年，是一个卓越的转化科学中心，由机构发展奖 (IDeA) 计划的生物医学研究卓越中心 (COBRE) 的资金支持，致力于针对新出现和重新出现的传染病开发和部署快速诊断、改进的治疗方法和负担得起的疫苗，这些疾病对亚太地区服务不足的社区造成了不成比例的影响。 COBRE 中心还寻求通过培训和指导夏威夷土著和其他代表性不足的太平洋岛民来增加生物医学研究队伍的多样性，因此，该中心的使命与国家普通医学科学研究所的使命完全一致，即支持基础医学。研究为疾病诊断、治疗和预防的进步奠定基础，并通过支持下一代科学家的培训来增加研究队伍的多样性(http://www.nigms.nih.gov/About/Pages/default.aspx) 针对新发传染病的第三阶段 COBRE 的主要目标是改善加快科学发现步伐、提高研究生产力的条件。该目标将通过以下方式实现：(1) 加强生物防护、生物信息学以及分子和细胞免疫学方面的 COBRE 核心的增长和可持续性，这些核心以以下三方面为基础：定制和协作服务、研究与开发以及教育和培训；(2) 制定和实施无国界的 COBRE 小额赠款计划，以促进合作和伙伴关系，促进数据和资源共享，并提供额外的指导和专业机会在第一阶段和第二阶段，IDeA 资助的研究中心开展了旨在改善人类健康的培训，这改变了指导和培训下一代研究人员的格局，并为多学科合作提供了最先进的核心资源。传染病研究在机构层面，COBRE 的资助促使人们做出了重大承诺，招募和留住新的富有成效的教师队伍，这种努力将持续到第三阶段，高层管理机构的承诺将确保该中心及其中心的可持续性。超过第三阶段 COBRE 时期的核心。

项目成果

Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus.

Muju 病毒由韩国的斑鸠鱼 (Myodes regulus) 携带，可能代表普马拉病毒 (Puumala 病毒) 的基因变种，普马拉病毒是啮齿类动物传播的汉坦病毒的原型。

• 发表时间: 2014-04
• 作者: Lee, Jin Goo;Gu, Se Hun;Baek, Luck Ju;Shin, Ok Sarah;Park, Kwang Sook;Kim, Heung;Klein, Terry A;Yanagihara, Richard;Song, Jin
• 通讯作者: Song, Jin

Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea).

欧洲鼹鼠（Talpa europaea）中高度分化的汉坦病毒谱系的分离和部分表征。

• 发表时间: 2016-02-19
• 影响因子: 4.6
• 作者: Gu, Se Hun;Kumar, Mukesh;Sikorska, Beata;Hejduk, Janusz;Markowski, Janusz;Markowski, Marcin;Liberski, Paweł P;Yanagihara, Richard
• 通讯作者: Yanagihara, Richard

A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections.

基于非结构蛋白 1 的高通量多重微球免疫分析可以区分三种黄病毒感染。

• 发表时间: 2019
• 影响因子: 3.8
• 作者: Tyson, Jasmine;Tsai, Wen;Tsai, Jih;Mässgård, Ludvig;Stramer, Susan L;Lehrer, Axel T;Nerurkar, Vivek R;Wang, Wei
• 通讯作者: Wang, Wei

Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan.

越南、马达加斯加和日本的啮齿动物传播的正汉坦病毒。

• 发表时间: 2021-07-12
• 作者: Kikuchi, Fuka;Senoo, Kae;Arai, Satoru;Tsuchiya, Kimiyuki;Sơn, Nguyễn Trường;Motokawa, Masaharu;Ranorosoa, Marie Claudine;Bawm, Saw;Lin, Kyaw San;Suzuki, Hitoshi;Unno, Akira;Nakata, Keisuke;Harada, Masashi;Tanaka;Morikawa, Shigeru
• 通讯作者: Morikawa, Shigeru

Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.

深入了解衰老细胞模型中水痘带状疱疹病毒感染（带状疱疹）期间免疫衰老的作用。

• 发表时间: 2015-11-03
• 作者: Kim, Ji;Park, Seul;Kumar, Mukesh;Lee, Chan;Shin, Ok Sarah
• 通讯作者: Shin, Ok Sarah