Development and Homeostasis of Skeletal Muscle in Health and Disease

健康和疾病中骨骼肌的发育和稳态

• 批准号: 8982136
• 负责人: Steven Burden
• 金额: $ 2.1万
• 依托单位: SOCIETY FOR MUSCLE BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8982136
• 关键词: Address; Adult; Age; Animal Model; Architecture; Area; Attention; Autoimmune Process; Awareness; Biological; Biology; California; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Connective Tissue; Development; Developmental Biology; Developmental Process; Disease; Elderly; Endocrine; Endocrine Glands; Ensure; Exercise; Feedback; Goals; Health; Homeostasis; Human; Human Genetics; Hybrids; Immune; Immunologist; Injury; International; Knowledge; Learning; Life; Location; Maintenance; Mentors; Metabolic; Mitochondria; Molecular; Molecular Biology; Motor; Movement; Muscle; Muscle Cells; Muscle Development; Muscle Spindles; Muscle function; Muscle satellite cell; Muscular Dystrophies; Myasthenia; Myasthenia Gravis; Myoblasts; Myopathy; Nerve; Neurologic; Nuclear; Organ; Organ Size; Participant; Pathology; Physiology; Positioning Attribute; Proprioception; Request for Applications; Research; Research Personnel; Role; Scientist; Sensory; Series; Signal Transduction; Skeletal Muscle; Societies; Spinal muscular atrophy congenital; Stem cells; Tissues; Translational Research; Work; abstracting; age related; cell type; chromatin remodeling; design; frontier; insight; lectures; meetings; motor control; muscle aging; muscle degeneration; muscle form; muscle regeneration; myogenesis; nerve supply; normal aging; posters; public health relevance; relating to nervous system; response to injury; sarcopenia; success; symposium

 DESCRIPTION (provided by applicant): This application requests support for an international meeting, "Development and homeostasis of skeletal muscle in health and disease", which is part of the "Frontiers in Myogenesis" series sponsored by the Society for Muscle Biology. This conference series has been held triennially with great success for more than 20 years. This specific meeting will be held from June 6-11, 2016 at the Asilomar Conference Grounds in Pacific Grove, California. We expect approximately 300 participants from around the world. This conference is timely and significant for three reasons: First, although great strides have been made in understanding how muscle forms during early development, much remains to be learned about the mechanisms that govern muscle homeostasis, ensuring that muscle responds to injury and disease and adapts to functional demands during adult life and normal aging, when muscle mass and function is reduced. This meeting will focus upon new developments and directions in studying muscle homeostasis. Second, this meeting will cover several exciting new themes, three mentioned here, that have not been covered in depth during previous muscle conferences. There is an increasing appreciation that muscle can function as an endocrine organ and provide signals, myokines, which govern differentiation and function of multiple organs. This new awareness will be an important theme of this meeting; we have dedicated one session to this topic and expect participation from scientists who are new to the muscle field. Likewise, there is an increasing appreciation that immune cells have a critical role in muscle regeneration, and we have planned for a session that will include immunologists and recent converts to muscle biology. Finally, muscle spindles are critical for proprioception and represent a hybrid muscle cell type designed as a sensory and motor organ. The development of this critical muscle cell type requires sensory innervation, and we have planned for a session that will cover the mechanisms that govern their formation and maintenance and how muscle spindles control motor movement. Third, we plan for a session that will cover exciting new developments in studying myopathies and strategies for treating these diseases. As usual, we will include muscular dystrophy, but we also plan for talks on spinal muscular atrophy, congenital myasthenia and myasthenia gravis. This diversity of topics will not only serve to educate scientists about diseases with which they may be unfamiliar but also highlight cutting- edge new strategies for treating these diseases. The meeting will also cover important, traditional topics, including the biology of muscle satellite cells, mechanisms of muscle degeneration and regeneration, muscle specification and differentiation, myoblast fusion, and muscle cell architecture including nuclear and mitochondrial positioning.

 描述（由申请人提供）：本申请请求支持“健康和疾病中骨骼肌的发育和稳态”国际会议，该会议是由肌肉生物学学会主办的“肌生成前沿”系列会议的一部分。系列会议每三年举办一次，20 多年来取得了巨大成功。本次会议将于 2016 年 6 月 6 日至 11 日在太平洋阿西洛玛会议场地举行。我们预计将有来自世界各地的大约 300 名与会者参加这次会议，其召开非常及时且意义重大，原因有以下三个：首先，尽管在了解肌肉在早期发育过程中如何形成方面取得了很大进展，但关于肌肉形成的机制仍有很多东西需要了解。控制肌肉稳态，应对肌肉对损伤和疾病的反应，适应成年后的功能需求，并确保肌肉质量和功能减少时的正常衰老。本次会议将重点讨论肌肉稳态研究的新进展和方向。会议将涵盖几个令人兴奋的新内容这里提到的三个主题在之前的肌肉会议中尚未深入讨论，人们越来越认识到肌肉可以作为内分泌器官并提供控制多个器官的分化和功能的信号。是本次会议的一个重要主题；我们专门举办了一场会议来讨论这个主题，并期待新进入肌肉领域的科学家参与。同样，人们越来越认识到免疫细胞在肌肉再生中发挥着关键作用，我们已经计划举行一次会议，其中包括免疫学家和最近的最后，肌梭对于本体感觉至关重要，代表一种被设计为感觉和运动器官的混合肌肉细胞类型。这种关键肌肉细胞类型的发育需要感觉神经支配，我们计划举办一个会议来涵盖。第三，我们计划举办一次会议，讨论研究肌病和治疗这些疾病的策略方面令人兴奋的新进展，但我们将包括肌营养不良症。还计划进行会谈脊髓性肌萎缩症、先天性肌无力和重症肌无力不仅有助于科学家了解他们可能不熟悉的疾病，而且还强调治疗这些疾病的前沿新策略。会议还将涵盖重要的传统疾病。主题包括肌肉卫星细胞的生物学、肌肉退化和再生的机制、肌肉规格和分化、成肌细胞融合以及包括核和线粒体定位在内的肌肉细胞结构。