Neurobiological and Behavioral Consequences of Cocaine Use in Mother/Infant Dyads

母婴二人使用可卡因的神经生物学和行为后果

基本信息

批准号：
9066232
负责人：
Josephine M. Johns
金额：
$ 31.38万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-15 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9066232
关键词：
Address Animal Experimentation Animal Model Animals Basic Science Behavior Behavioral Biological Brain Caring Characteristics Child Child Rearing Clinical Clinical Research Cocaine Cocaine Abuse Communication Communities Core Facility Crying Cues Data Analyses Development Disease Drug abuse Drug usage Early Diagnosis Endocrine Exhibits Fetal Cocaine Exposure Functional Magnetic Resonance Imaging Gene Expression Human Human Resources Image Image Analysis Individual Infant Infant Care Interdisciplinary Study International Intervention Lead Light Maternal Behavior Measurement Measures Methods Modeling Mothers Neurobiology Neurologic Oxytocin Pathway interactions Pattern Perception Pharmaceutical Preparations Physiological Population Postpartum Period Pregnancy Principal Investigator Psyche structure Regulation Research Research Personnel Research Project Grants Research Proposals Rodent Rodent Model Scientist Stimulus Stress Structural defect Structure Techniques Touch sensation Translating Translational Research Utah Ventricular Visual Woman Work base behavioral response cocaine exposure cocaine use data management drug of abuse fetal drug exposure high risk innovation innovative technologies insight interest maternal cocaine use multidisciplinary neglect neonate neural circuit neuroimaging non-drug novel offspring postnatal preference prenatal exposure programs response segmentation Image analysis skills success tool vocalization

项目摘要

This program project is a multidisciplinary, translational research project employing animal and human projects to focus on the elucidation of neurobiological and behavioral characteristics and responses of mothers that have used primarily cocaine during pregnancy and of offspring prenatally exposed to cocaine that might impact negatively on normal mother-infant interactions. Although maternal cocaine use is known to be highly correlated with maternal neglect and poorer mother-infant interactions in both human and animal models, there is little direct research on perceptual, endocrine and neurological responses of these women when presented with relevant infant cues (cries, touch, pictures). Similarly, little is known about abnormal physiological/behavioral responses in infants prenatally exposed to cocaine that may impact parenting behaviors of both drug using and non-using mothers. One animal, and 2 human clinical projects will address three main hypotheses which address the possibility that cocaine use by mothers and/or prenatal exposure to cocaine in offspring could result in drug-induced neurological and/or bio-behavioral abnormalities in both, that contribute to neglect and poor mother-infant interactions in animals and humans. The animal project will assess specific characteristics of infant stimuli or behavior (vocalizations, thermoregulatory ability, olfactory cues, response to mothers presence) and brain structural abnormalities (regional, ventricular differences) and gene expression as well as measuring differential maternal behavioral and endocrine responses to and preference for exposed compared to non-exposed infants or stimuli produced by infants. The human projects will focus on perceptual, endocrine and behavioral responses to stress related and infant related stimuli and infant response to mothers, as well as infant brain structural and pathway developmental abnormalities (project 2) and (project 3) measurement of maternal (fMRI) endocrine and neurological brain regional responses to infant stimuli (cries, visual vignettes). We hypothesize differences in behavioral, physiological and/or neurological characteristics (infant cries, infant stimulus cues, physical elicitation of care and brain structural abnormalities) of both human and rodent offspring (prenatally drug exposed versus non-exposed), which could result in differential maternal response. We predict that mothers who have abused cocaine will exhibit differences in perceptual, behavioral, endocrine and/or neurological responses to relevant infant stimuli compared to non-drug users. This translational, interdisciplinary project will allow researchers from different research backgrounds and expertise to work together to better identify specific attributes of mothers and infants that could contribute to a better understanding of how drugs of abuse specifically and particular characteristics of individuals in general may influence neglect. This could result in early and continuing intervention strategies to offset some of the negative consequences in this population.

该计划项目是一个多学科的转化研究项目，采用动物和人类项目，专注于阐明神经生物学和行为特征和母亲的反应，这些母亲的反应主要在怀孕期间主要使用可卡因和在产前暴露于可卡因的后代对正常母亲互动产生负面影响的可卡因。尽管众所周知，母体可卡因的使用与孕产妇的疏忽和较差的人类和动物模型中的母亲相互作用高度相关，但在获得相关婴儿提示（哭泣，触摸，触摸，图片）时，几乎没有直接研究这些妇女的感知，内分泌和神经系统反应。同样，对于可卡因的婴儿的生理/行为反应异常，对可卡因可能会影响使用和不使用母亲的药物的育儿行为。一只动物和2个人类临床项目将解决三个主要的假设解决了母亲在后代中可卡因和/或在可卡因中使用可卡因的可能性，可能会导致两者中药物诱导的神经系统和/或生物行为异常，这有助于忽视动物和人类的母亲互动。该动物项目将评估婴儿刺激或行为的特定特征（发声，温度调节能力，嗅觉提示，对母亲存在的反应）和大脑结构异常（区域，心室差异）和基因表达以及与婴儿产生的非暴露婴儿或刺激的差异母体行为和内分泌反应以及对暴露的偏爱。人类项目将集中于对与母亲相关的刺激和婴儿对母亲的感知，内分泌和行为反应，以及婴儿的大脑结构和途径的发育异常（项目2）和（项目3）测量母体（FMRI）内分泌和神经学内分泌和神经学大脑对婴儿刺激的反应对婴儿刺激（criutant actimulia tisuals oftant actimuli（Cries cries cries cries），Visuals Visuals，Visuals，Visuals，Visuals，Visuals，Vistuer，Vignes）。我们假设行为，生理和/或神经系统特征的差异（婴儿哭泣，婴儿刺激线索，对护理和大脑的身体启发人和啮齿动物后代的结构异常（产前药物暴露与非暴露），这可能导致孕产妇反应差异。我们预测，与非药物使用者相比，滥用可卡因的母亲在感知，行为，内分泌和/或神经系统反应方面会表现出差异。这个翻译，跨学科的项目将使来自不同研究背景和专业知识的研究人员能够更好地确定母亲和婴儿的特定属性，这些属性可以更好地了解虐待药物的特定和个人特定特征，从而可能影响忽视。这可能会导致早期和持续的干预策略，以抵消该人群中一些负面后果。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Maternal neglect: oxytocin, dopamine and the neurobiology of attachment.

DOI：
10.1111/j.1365-2826.2011.02228.x
发表时间：
2011-11
期刊：
Journal of neuroendocrinology
影响因子：
3.2
作者：
Strathearn L
通讯作者：
Strathearn L

Enhanced Cortical Thickness Measurements for Rodent Brains via Lagrangian-based RK4 Streamline Computation.

通过基于拉格朗日的 RK4 流线计算增强啮齿动物大脑的皮质厚度测量。

DOI：
10.1117/12.2216420
发表时间：
2016
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Lee,Joohwi;Kim,SunHyung;Oguz,Ipek;Styner,Martin
通讯作者：
Styner,Martin

Use of High Resolution 3D Diffusion Tensor Imaging to Study Brain White Matter Development in Live Neonatal Rats.

DOI：
10.3389/fpsyt.2011.00054
发表时间：
2011
期刊：
Frontiers in psychiatry
影响因子：
4.7
作者：
Cai Y;McMurray MS;Oguz I;Yuan H;Styner MA;Lin W;Johns JM;An H
通讯作者：
An H

Development of translational methods in spectral analysis of human infant crying and rat pup ultrasonic vocalizations for early neurobehavioral assessment.

开发人类婴儿哭泣和大鼠幼崽超声发声频谱分析的转化方法，用于早期神经行为评估。

DOI：
10.3389/fpsyt.2011.00056
发表时间：
2011
期刊：
Frontiers in psychiatry
影响因子：
4.7
作者：
Zeskind,PhilipSanford;McMurray,MatthewS;Garber,KristinA;Neuspiel,JulianaM;Cox,ElizabethT;Grewen,KarenM;Mayes,LindaC;Johns,JosephineM
通讯作者：
Johns,JosephineM

Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure.