"UAB Metabolomics Workshop: from design to decision"

“UAB代谢组学研讨会：从设计到决策”

• 批准号: 8912500
• 负责人: STEPHEN BARNES
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-18 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8912500
• 关键词: Alabama; American; Applications Grants; Automation; Award; Bioinformatics; Biomedical Research; Biometry; Characteristics; Collaborations; Collection; Communities; Computer software; Consultations; Data; Data Analyses; Data Set; Development; Discipline; Education; Educational process of instructing; Educational workshop; Elements; Ensure; Environment; Evaluation; Experimental Designs; Faculty; Faculty Workshop; Feedback; Fees; Fellowship; Food; Funding; Gender; Goals; Health; Informatics; Investments; Lead; Learning; Location; Mass Spectrum Analysis; Methods; Modification; Nuclear Magnetic Resonance; Participant; Phase; Postdoctoral Fellow; Process; Protocols documentation; Published Comment; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Selection Criteria; Series; Shapes; Site; Statistical Data Interpretation; Students; Technology; Testing; Training; Translational Research; Travel; Underrepresented Minority; Universities; analytical tool; cost; design; disability; education evaluation; experience; graduate student; investigator training; lectures; meetings; metabolomics; programs; research study; responsible research conduct; skills; web site

DESCRIPTION (provided by applicant): This is an application for the development and presentation of a 4-day Workshop on metabolomics. While the framework of all aspects of metabolomics will be presented to the attendees, the ultimate goal of the Workshop is to prepare investigators to advance the use of metabolomics in translational research and to direct highly interdisciplinary teams or collaborations in metabolomic studies. To that end, the Workshop will have a specific focus on development of experimental designs that will allow for the meaningful execution of metabolomics research. In combination with this emphasis, the Workshop will provide an organized, hands-on experience in metabolomics. The goal is to ensure in this round of -omics development, that attendees will learn from experiences gained from the last 15 years of -omics research. In the first year, with strong institutional support, th Workshop will be in a developmental phase and will be restricted to up to 16 participants. This is to carefully test the hands-on experience that will constitute nearly 50% of the Workshop activities before it is expanded to the 40 attendees who will attend the full Workshop in years 2-5. We will use feedback/advice given by the speakers and attendees of the first course to refine all aspects of the course - and continue throughout each year to use both feedback comments and assessment of how former attendees are using metabolomics to guide us in determining the content and shape of subsequent Workshops. The Workshop will consist of five main didactic sections: (1) understanding what metabolomics/metabonomics is and how to design a metabolomics experiment; (2) critical issues in collection and storage of samples; (3) rationales for choosing the analytical tools of metabolomics, mass spectrometry (MS) and nuclear magnetic resonance (NMR); (4) processing of collected metabolomics data and statistical analysis of high dimensional data; and (5) bioinformatics, software and computer resource needs for metabolomics. Attendees will be introduced to each of these through a hands-on experience - they will process samples for both MS and NMR analysis where attendees will be given analysis protocols that range from ideal/optimized to specifically corrupted data. These protocols will be designed to show the consequence of poor design. All samples will be processed so that the attendees can apply the analytical, statistical and bioinformatic methods they've been taught in the didactic sessions. In the last session, attendees and the Workshop faculty will discuss the data that has been obtained. There will be up to 10 student/postdoc fellowships that will be awarded through a competitive process for Workshops in year 2-5. These will consist of the registration, hotel/food costs and travel to the Workshop. Graded registration fees will apply to the other students/postdocs, faculty and non- university attendees. Emphasis will be placed ensuring gender equality and underserved minority recruitment. UAB is a superb environment for this Workshop because of its excellent investment in the technologies needed for metabolomics, the strength of its biostatistic research faculty and its investment in bioinformatics.

描述（由申请人提供）：这是为期4天的代谢组学讲习班开发和介绍的应用程序。虽然将向与会者展示代谢组学各个方面的框架，但研讨会的最终目的是准备研究人员在转化研究中促进使用代谢组学，并指导高度跨学科的团队或代谢组研究中的合作。为此，研讨会将特别关注实验设计的开发，这将允许对代谢组学研究的有意义执行。结合这种重点，研讨会将提供有组织的代谢组学经验。目的是确保在这一轮发展中，与会者将从过去15年的 - 组学研究中获得的经验学习。在第一年，在机构的强烈支持下，TH将处于发展阶段，最多仅限16名参与者。这是为了仔细测试将构成研讨会活动的近50％的动手经验，然后将其扩展到40名与会者，他们将在2 - 5年内参加整个研讨会。我们将使用第一门课程的演讲者和参与者提供的反馈/建议来完善课程的各个方面 - 并在每年的一年中继续使用反馈意见和评估前与会者如何使用代谢组学来指导我们确定后续工作坊的内容和形状。研讨会将由五个主要的教学部分组成：（1）了解什么是代谢组学/代谢组学以及如何设计代谢组学实验； （2）样品收集和存储中的关键问题； （3）选择代谢组学，质谱法（MS）和核磁共振（NMR）的分析工具的理由； （4）处理收集的代谢组学数据和高维数据的统计分析； （5）代谢组学的生物信息学，软件和计算机资源需求。将通过动手体验向与会者介绍这些参与者 - 他们将处理MS和NMR分析的样本，其中将为与会者提供从理想/优化到特定损坏的数据范围的分析协议。这些协议将旨在显示不良设计的后果。所有样本将进行处理，以便与会者可以应用教义会议中教授的分析，统计和生物信息学方法。在上一届会议中，与会者和研讨会教师将讨论已获得的数据。最多将有10个学生/博士后奖学金，这些奖学金将通过2 - 5年的研讨会授予。这些将包括注册，酒店/食品费用和前往研讨会的旅行。分级注册费将适用于其他学生/博士后，教职员工和非大学与会者。 将重点放置，以确保性别平等和服务不足的少数族裔招募。 UAB是该研讨会的绝佳环境，因为它在代谢组学所需的技术，生物统计学研究学院的优势以及对生物信息学的投资中的优势进行了出色的投资。