Delaware Center for Musculoskeletal Research – Multiscale Assessments Research Core

特拉华州肌肉骨骼研究中心 — 多尺度评估研究核心

基本信息

批准号：
10091021
负责人：
LIYUN WANG
金额：
$ 60.81万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-15 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10091021
关键词：
Animals Basic Science Biological Biological Models Biological Sciences Biomechanics Biomedical Research Biophysics Biostatistics Core Biotechnology Communities Competence Computers and Advanced Instrumentation Cues Delaware Disease Educational workshop Engineering Ensure Equipment Functional disorder Funding Goals Health Image Individual Institutes Lead Leadership Measurement Methodology Molecular Musculoskeletal Organism Pre-Clinical Model Reproducibility Research Research Infrastructure Research Personnel Research Project Grants Resources Scientist Services Signal Transduction Structure Technical Expertise Techniques Therapeutic Intervention Tissues Training Universities Work bioimaging biomechanical model biophysical model design in vivo imaging instrument instrumentation mechanical load pre-clinical pre-clinical research programs response square foot success

项目摘要

Project Summary / Abstract The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. Unraveling the interconnected responses at multiple levels will require an integrated application of advanced biomechanical and bioimaging techniques with preclinical (animal) and biophysical (explant) model systems. This requirement is not easily met using standard instrumentation typically available in research centers, and state-of-the-art equipment, technical expertise to use this equipment, and scientific expertise across multiple platforms to guide the design and application of these techniques is needed. The goal of the Multiscale Assessments Research Core is to maximize the success and impact of DCMR Research Project, Project Leaders, and other researchers by providing a Research Core that includes state-of- the-art equipment to apply and assess physical cues and biological signals. The Core will use a gateway organizational framework that is built around interlinked scientific leadership, technical expertise, user training, and partnerships with existing collaborative Centers. The Research Core will provide, develop, and support multiscale mechanical loading and measurement capability, expertise, and training (Aim 1); provide, develop, and support preclinical and biophysical models, including assessment capability, expertise, and training (Aim 2); and enhance the existing Bioimaging Center (Aim 3). The Research Core will obtain new state-of-the-art equipment, including the construction of new instruments to apply physical cues and molecular signals to living systems and the purchase of advanced instrumentation for in vivo imaging. The Research Core will be housed in a newly renovated 1400 sq. ft. lab space adjacent to the vivarium. The coordination of musculoskeletal resources and expertise in the DCMR Multiscale Assessments Research Core will accelerate the research pace for Project Leaders and Center users. The use of Core’s resources for research questions at the interface of engineering and life sciences will have a synergistic effect that will strengthen UD’s biomedical research infrastructure and impact.

项目概要/摘要特拉华州肌肉骨骼研究中心 (DCMR) 将支持基础和临床前研究肌肉骨骼健康和疾病的中心主题，从整个身体的水平到分子，强调物理和生物线索影响组织结构和正常的机制揭示功能、功能障碍和潜在的治疗干预措施。多个层次将需要先进的生物力学和生物成像技术的综合应用使用标准很难满足临床前（动物）和生物物理（外植体）模型系统的要求。研究中心通常提供的仪器、最先进的设备、可使用的技术专业知识该设备以及跨多个平台的科学专业知识来指导这些设备的设计和应用需要技术。多尺度评估研究核心的目标是最大限度地提高 DCMR 的成功和影响研究项目、项目负责人和其他研究人员通过提供包括现状的研究核心核心将使用网关来应用和评估物理线索和生物信号。围绕相互关联的科学领导力、技术专长、用户培训建立的组织框架，以及与现有合作中心的合作伙伴关系将提供、开发和支持。多尺度机械载荷和测量能力、专业知识和培训（目标 1）；并支持临床前和生物物理模型，包括评估能力、专业知识和培训（目标 2)；并加强现有的生物成像中心（目标 3）。研究核心将获得最先进的新设备，包括建造新仪器将物理线索和分子信号应用于生命系统并购买先进的仪器用于体内成像的研究核心将坐落在一个新装修的 1400 平方英尺的实验室空间中，毗邻 DCMR 多尺度评估中肌肉骨骼资源和专业知识的协调。研究核心将加快项目领导者和中心用户的研究步伐。工程和生命科学交叉领域的研究问题资源将产生协同效应这将加强特拉华大学的生物医学研究基础设施和影响力。